SKPin C1

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Cat.No. 4817 - SKPin C1 | C18H13BrN2O4S2 | CAS No. 432001-69-9
Description: Inhibits Skp2-mediated p27 degradation; induces cell cycle arrest
Chemical Name: 2-[4-Bromo-2-[[4-oxo-3-(3-pyridinylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]phenoxy]acetic acid
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews
Literature (3)

Biological Activity

Inhibitor of Skp2-mediated p27 degradation. Induces p27 accumulation in metastatic melanoma cell lines. Promotes G1/S cell cycle arrest in T47D cells and LNCaP cells; induces G2/M cell cycle arrest in MCF-7 cells.

Technical Data

M. Wt 465.34
Formula C18H13BrN2O4S2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 432001-69-9
PubChem ID 5733396
InChI Key IYCJJVVXEHZJHE-CHHVJCJISA-N
Smiles BrC1=CC=C(OCC(O)=O)C(/C=C2\SC(N(CC3=CN=CC=C3)C2=O)=S)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.65 10

Preparing Stock Solutions

The following data is based on the product molecular weight 465.34. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.49 mL 107.45 mL 214.9 mL
0.5 mM 4.3 mL 21.49 mL 42.98 mL
1 mM 2.15 mL 10.74 mL 21.49 mL
5 mM 0.43 mL 2.15 mL 4.3 mL

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References

References are publications that support the biological activity of the product.

Rico-Bautista and Wolf (2012) Skipping cancer: small molecule inhibitors of SKP2-mediated p27 degradation. Chem.Biol. 19 1497 PMID: 23261592

Wu et al (2012) Specific small molecule inhibitors of Skp2-mediated p27 degradation. Chem.Biol. 19 1515 PMID: 23261596


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Keywords: SKPin C1, SKPin C1 supplier, SKPinC1, skp2, SCF, E3, ligases, p27, accumulation, cell, cycle, arrest, inhibits, inhibitors, antitumor, Ubiquitin, Ligases, Cell, Cycle, Inhibitors, 4817, Tocris Bioscience

2 Citations for SKPin C1

Citations are publications that use Tocris products. Selected citations for SKPin C1 include:

Kramer et al (2016) Proliferation and Survival of Embryonic Sympathetic Neuroblasts by MYCN and Activated ALK Signaling. J Neurosci 36 10425 PMID: 27707976

Brough et al (2018) Identification of highly penetrant Rb-related synthetic lethal interactions in triple negative breast cancer. Oncogene PMID: 29915391


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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