SKPin C1

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Cat.No. 4817 - SKPin C1 | C18H13BrN2O4S2 | CAS No. 432001-69-9
Description: Inhibits Skp2-mediated p27 degradation; induces cell cycle arrest
Chemical Name: 2-[4-Bromo-2-[[4-oxo-3-(3-pyridinylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]phenoxy]acetic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Inhibitor of Skp2-mediated p27 degradation. Induces p27 accumulation in metastatic melanoma cell lines. Promotes G1/S cell cycle arrest in T47D cells and LNCaP cells; induces G2/M cell cycle arrest in MCF-7 cells.

Technical Data

M. Wt 465.34
Formula C18H13BrN2O4S2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 432001-69-9
PubChem ID 5733396
InChI Key IYCJJVVXEHZJHE-CHHVJCJISA-N
Smiles BrC1=CC=C(OCC(O)=O)C(/C=C2\SC(N(CC3=CN=CC=C3)C2=O)=S)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.65 10

Preparing Stock Solutions

The following data is based on the product molecular weight 465.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.15 mL 10.74 mL 21.49 mL
5 mM 0.43 mL 2.15 mL 4.3 mL
10 mM 0.21 mL 1.07 mL 2.15 mL
50 mM 0.04 mL 0.21 mL 0.43 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Rico-Bautista and Wolf (2012) Skipping cancer: small molecule inhibitors of SKP2-mediated p27 degradation. Chem.Biol. 19 1497 PMID: 23261592

Wu et al (2012) Specific small molecule inhibitors of Skp2-mediated p27 degradation. Chem.Biol. 19 1515 PMID: 23261596


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Literature in this Area

Programmed Cell Death

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for SKPin C1

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