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Inhibitor of Skp2-mediated p27 degradation. Induces p27 accumulation in metastatic melanoma cell lines. Promotes G1/S cell cycle arrest in T47D cells and LNCaP cells; induces G2/M cell cycle arrest in MCF-7 cells.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 465.34. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||21.49 mL||107.45 mL||214.9 mL|
|0.5 mM||4.3 mL||21.49 mL||42.98 mL|
|1 mM||2.15 mL||10.74 mL||21.49 mL|
|5 mM||0.43 mL||2.15 mL||4.3 mL|
References are publications that support the biological activity of the product.
Rico-Bautista and Wolf (2012) Skipping cancer: small molecule inhibitors of SKP2-mediated p27 degradation. Chem.Biol. 19 1497 PMID: 23261592
Wu et al (2012) Specific small molecule inhibitors of Skp2-mediated p27 degradation. Chem.Biol. 19 1515 PMID: 23261596
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Keywords: SKPin C1, SKPin C1 supplier, SKPinC1, skp2, SCF, E3, ligases, p27, accumulation, cell, cycle, arrest, inhibits, inhibitors, antitumor, Ubiquitin, Ligases, Cell, Cycle, Inhibitors, 4817, Tocris Bioscience
2 Citations for SKPin C1
Citations are publications that use Tocris products. Selected citations for SKPin C1 include:
Kramer et al (2016) Proliferation and Survival of Embryonic Sympathetic Neuroblasts by MYCN and Activated ALK Signaling. J Neurosci 36 10425 PMID: 27707976
Brough et al (2018) Identification of highly penetrant Rb-related synthetic lethal interactions in triple negative breast cancer. Oncogene PMID: 29915391
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Targeted Protein Degradation Research Product GuideUpdated
This brochure highlights the tools and services available from Bio-Techne to support Targeted Protein Degradation research, including:
- Active Degraders
- Degrader Building Blocks
- Custom Degrader Services
- UPS Proteins and Assays
- Assays for Protein Degradation
Programmed Cell Death Poster
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.
Targeted Protein Degradation Poster
Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia