SK 609

Pricing Availability   Qty
Cat.No. 7039 - SK 609 | C10H14ClN.HCl | CAS No. 1092797-77-7
Description: Dopamine D3 receptor biased agonist
Chemical Name: 2-chloro-α-methyl-benzenepropanamine hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (5)

Biological Activity

Dopamine D3 receptor biased agonist. Preferentially signals via the G protein-dependent pathway (EC50 values for G protein and β-arrestin-dependent signaling are 1.1 and 50.2 μM, respectively). Exhibits selectivity for D3 over D2 receptors. Improves motor deficits in rodent Parkinson's disease models and ameliorates L-DOPA (Cat. No. 3788) induced abnormal involuntary movements.

Technical Data

M. Wt 220.14
Formula C10H14ClN.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1092797-77-7
InChI Key NVCYSMVSGDVJQR-UHFFFAOYSA-N
Smiles CC(CCC1=C(C=CC=C1)Cl)N.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 22.01 100
DMSO 22.01 100

Preparing Stock Solutions

The following data is based on the product molecular weight 220.14. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.54 mL 22.71 mL 45.43 mL
5 mM 0.91 mL 4.54 mL 9.09 mL
10 mM 0.45 mL 2.27 mL 4.54 mL
50 mM 0.09 mL 0.45 mL 0.91 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References

References are publications that support the biological activity of the product.

Xu et al (2017) Functional characterization of a novel series of biased signaling dopamine D3 receptor agonists. ACS Chem.Neurosci. 8 486 PMID: 27801563

Simms et al (2016) In vivo characterization of a novel dopamine D3 receptor agonist to treat motor symptoms of Parkinson's disease. Neuropharmacology 100 106 PMID: 25896768


If you know of a relevant reference for SK 609, please let us know.

View Related Products by Target

View Related Products by Product Action

View all D3 Receptor Agonists

Keywords: SK 609, SK 609 supplier, SK609, dopamine, d3, receptor, biased, agonists, agonism, parkinsons, disease, g, protein, dependent, signaling, D3, Receptors, 7039, Tocris Bioscience

Citations for SK 609

Citations are publications that use Tocris products.

Currently there are no citations for SK 609. Do you know of a great paper that uses SK 609 from Tocris? Please let us know.

Reviews for SK 609

There are currently no reviews for this product. Be the first to review SK 609 and earn rewards!

Have you used SK 609?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Neurodegeneration

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease
Dopamine Receptors

Dopamine Receptors Scientific Review

Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.

Addiction

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.

Parkinson's

Parkinson's Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.