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Biological Activity for L-DOPA
L-DOPA is an immediate precursor of dopamine, produced by tyrosine hydroxylase. Displays antiParkinsonian activity.
Technical Data for L-DOPA
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for L-DOPA
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for L-DOPA
The following data is based on the product molecular weight 197.19. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||10.14 mL||50.71 mL||101.43 mL|
|2.5 mM||2.03 mL||10.14 mL||20.29 mL|
|5 mM||1.01 mL||5.07 mL||10.14 mL|
|25 mM||0.2 mL||1.01 mL||2.03 mL|
References for L-DOPA
References are publications that support the biological activity of the product.
Pisani and Shen (2009) Levodopa-induced dyskinesia and striatal signaling pathways. Proc.Natl.Acad.Sci.USA 106 2973
If you know of a relevant reference for L-DOPA, please let us know.
Keywords: L-DOPA, L-DOPA supplier, dopamine, precursor, non-selective, receptors, parkinson's, parkinsons, Levodopa, Non-selective, Dopamine, 3788, Tocris Bioscience
5 Citations for L-DOPA
Citations are publications that use Tocris products. Selected citations for L-DOPA include:
Christopher P et al (2021) Cocaine shifts dopamine D2 receptor sensitivity to gate conditioned behaviors. Neuron 109 3421-3435.e5 PMID: 34506723
Alexander G et al (2021) Dopamine differentially modulates the size of projection neuron ensembles in the intact and dopamine-depleted striatum. Elife 10 PMID: 33983121
Marc et al (2021) Transcriptional co-activator regulates melanocyte differentiation and oncogenesis by integrating cAMP and MAPK/ERK pathways. Cell Rep 35 109136 PMID: 34010639
Xiao et al (2018) A Basal Ganglia Circuit Sufficient to Guide Birdsong Learning. Neuron 98 208 PMID: 29551492
Robert et al (2022) Dopamine signaling modulates microglial NLRP3 inflammasome activation: implications for Parkinson's disease. J Neuroinflammation 19 50 PMID: 35172843
Do you know of a great paper that uses L-DOPA from Tocris? Please let us know.
Reviews for L-DOPA
Average Rating: 5 (Based on 1 Review.)
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.