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Submit ReviewL-DOPA
Description: Dopamine precursor
Alternative Names: Levodopa
Chemical Name: L-3,4-Dihydroxyphenylalanine
Purity: ≥98% (HPLC)
Biological Activity for L-DOPA
L-DOPA is an immediate precursor of dopamine, produced by tyrosine hydroxylase. Displays antiParkinsonian activity.
Technical Data for L-DOPA
| M. Wt | 197.19 |
| Formula | C9H11NO4 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 59-92-7 |
| PubChem ID | 6047 |
| InChI Key | WTDRDQBEARUVNC-LURJTMIESA-N |
| Smiles | OC1=C(O)C=CC(C[C@H](N)C(O)=O)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for L-DOPA
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 0.99 | 5 | |
| 1eq. HCl | 9.86 | 50 |
Preparing Stock Solutions for L-DOPA
The following data is based on the product molecular weight 197.19. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 10.14 mL | 50.71 mL | 101.43 mL |
| 2.5 mM | 2.03 mL | 10.14 mL | 20.29 mL |
| 5 mM | 1.01 mL | 5.07 mL | 10.14 mL |
| 25 mM | 0.2 mL | 1.01 mL | 2.03 mL |
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Product Datasheets for L-DOPA
References for L-DOPA
References are publications that support the biological activity of the product.
Pisani and Shen (2009) Levodopa-induced dyskinesia and striatal signaling pathways. Proc.Natl.Acad.Sci.USA 106 2973
If you know of a relevant reference for L-DOPA, please let us know.
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Keywords: L-DOPA, L-DOPA supplier, dopamine, precursor, non-selective, receptors, parkinson's, parkinsons, Levodopa, Non-selective, Dopamine, 3788, Tocris Bioscience
⚠ WARNING: This product can expose you to chemicals including Levodopa, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov
1 Citation for L-DOPA
Citations are publications that use Tocris products. Selected citations for L-DOPA include:
Xiao et al (2018) A Basal Ganglia Circuit Sufficient to Guide Birdsong Learning. Neuron 98 208 PMID: 29551492
Do you know of a great paper that uses L-DOPA from Tocris? Please let us know.
Reviews for L-DOPA
Average Rating: 5 (Based on 1 Review.)
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Very stable compound.
By
Luiz Alexandre Magno on 10/26/2018
Assay Type: In Vivo
Species: Mouse
I have used L-DOPA to increase dopamine in mouse brain. There was an increase in dopamine levels in the striatum of animals treated with 4 injections of L-DOPA.
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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