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Description: Dopamine precursor
Alternative Names: Levodopa
Chemical Name: L-3,4-Dihydroxyphenylalanine
Purity: ≥98% (HPLC)
Citations (5)
Reviews (1)
Literature (2)

Biological Activity for L-DOPA

L-DOPA is an immediate precursor of dopamine, produced by tyrosine hydroxylase. Displays antiParkinsonian activity.

Technical Data for L-DOPA

M. Wt 197.19
Formula C9H11NO4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 59-92-7
PubChem ID 6047
Smiles OC1=C(O)C=CC(C[C@H](N)C(O)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for L-DOPA

Solvent Max Conc. mg/mL Max Conc. mM
water 0.99 5
1eq. HCl 9.86 50

Preparing Stock Solutions for L-DOPA

The following data is based on the product molecular weight 197.19. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 10.14 mL 50.71 mL 101.43 mL
2.5 mM 2.03 mL 10.14 mL 20.29 mL
5 mM 1.01 mL 5.07 mL 10.14 mL
25 mM 0.2 mL 1.01 mL 2.03 mL

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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Product Datasheets for L-DOPA

Certificate of Analysis / Product Datasheet
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References for L-DOPA

References are publications that support the biological activity of the product.

Pisani and Shen (2009) Levodopa-induced dyskinesia and striatal signaling pathways. Proc.Natl.Acad.Sci.USA 106 2973

If you know of a relevant reference for L-DOPA, please let us know.

View Related Products by Target

Keywords: L-DOPA, L-DOPA supplier, dopamine, precursor, non-selective, receptors, parkinson's, parkinsons, Levodopa, Non-selective, Dopamine, 3788, Tocris Bioscience

⚠ WARNING: This product can expose you to chemicals including Levodopa, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

5 Citations for L-DOPA

Citations are publications that use Tocris products. Selected citations for L-DOPA include:

Robert et al (2022) Dopamine signaling modulates microglial NLRP3 inflammasome activation: implications for Parkinson's disease. J Neuroinflammation 19 50 PMID: 35172843

Christopher P et al (2021) Cocaine shifts dopamine D2 receptor sensitivity to gate conditioned behaviors. Neuron 109 3421-3435.e5 PMID: 34506723

Alexander G et al (2021) Dopamine differentially modulates the size of projection neuron ensembles in the intact and dopamine-depleted striatum. Elife 10 PMID: 33983121

Marc et al (2021) Transcriptional co-activator regulates melanocyte differentiation and oncogenesis by integrating cAMP and MAPK/ERK pathways. Cell Rep 35 109136 PMID: 34010639

Xiao et al (2018) A Basal Ganglia Circuit Sufficient to Guide Birdsong Learning. Neuron 98 208 PMID: 29551492

Do you know of a great paper that uses L-DOPA from Tocris? Please let us know.

Reviews for L-DOPA

Average Rating: 5 (Based on 1 Review.)

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Very stable compound.
By Luiz Alexandre Magno on 10/26/2018
Assay Type: In Vivo
Species: Mouse

I have used L-DOPA to increase dopamine in mouse brain. There was an increase in dopamine levels in the striatum of animals treated with 4 injections of L-DOPA.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Dopamine Receptors Scientific Review

Dopamine Receptors Scientific Review

Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.

Parkinson's Disease Poster

Parkinson's Disease Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.