Lamotrigine

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Cat.No. 1611 - Lamotrigine | C9H7Cl2N5 | CAS No. 84057-84-1
Description: Inhibits glutamate release. Anticonvulsant
Chemical Name: 6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Anticonvulsant. Inhibits glutamate release, possibly through inhibition of Na+, K+ and Ca2+ currents. Also blocks heterologously expressed and native α4β2 nAChRs with a similar affinity to Na+ channels. Water-soluble salt available (lamotrigine isethionate, Cat. No. 2289).

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Technical Data

M. Wt 256.09
Formula C9H7Cl2N5
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 84057-84-1
PubChem ID 3878
InChI Key PYZRQGJRPPTADH-UHFFFAOYSA-N
Smiles NC1=NC(N)=C(N=N1)C1=CC=CC(Cl)=C1Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 25.61 100
ethanol 2.56 10

Preparing Stock Solutions

The following data is based on the product molecular weight 256.09. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.9 mL 19.52 mL 39.05 mL
5 mM 0.78 mL 3.9 mL 7.81 mL
10 mM 0.39 mL 1.95 mL 3.9 mL
50 mM 0.08 mL 0.39 mL 0.78 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Grunze et al (1998) Modulation of calcium and potassium currents by lamotrigine. Neuropsychobiology 38 131 PMID: 9778600

Leach et al (1991) Neurochemical and behavioral aspects of lamotrigine. Epilepsia 32 S4 PMID: 1685439

Zheng et al (2010) The anticonvulsive drug lamotrigine blocks neuronal α4β2 nicotinic acetylcholine receptors. J.Pharmacol.Exp.Ther. 335 401 PMID: 20688974

Zona and Avoli (1997) Lamotrigine reduces voltage-gated sodium currents in rat central neurons in culture. Epilepsia 38 522 PMID: 9184596


If you know of a relevant reference for Lamotrigine, please let us know.

Keywords: Lamotrigine, supplier, inhibitors, glutamate, release, Anticonvulsant, Blocks, Na+, K+, Ca2+, calcium, sodium, potassium, channels, inhibits, Glutamate, mGlur, Receptors, Metabotropic, iGluR, Ionotropic, Channel, modulators, VDAC, GlaxoSmithKline, GSK, Miscellaneous, Glutamate, Other, Channel, Modulators, Miscellaneous, Glutamate, Tocris Bioscience

1 Citation for Lamotrigine

Citations are publications that use Tocris products. Selected citations for Lamotrigine include:

Kashyap et al (2015) Characterization of the role of HCN channels in β3-adrenoceptor mediated rat bladder relaxation. J Neurosci 2 PMID: 26709376


Do you know of a great paper that uses Lamotrigine from Tocris? If so please let us know.

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