SGC AAK1 1

Pricing Availability   Qty
Cat.No. 6528 - SGC AAK1 1 | C21H25N5O3S
Description: AAK1 and BMP2K inhibitor; activates Wnt signaling
Chemical Name: N-(6-(3-((N,N-diethylsulfamoyl)amino)phenyl)-1H-indazol-3-yl)cyclopropanecarboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Adaptor-associated protein kinase 1 (AAK1) and BMP-2-inducible protein kinase (BMP2K) inhibitor (IC50 values are 233 nM and 1.48 μM for AAK1 and BMP2K, respectively). Inhibits AAK1-dependent phosphorylation of AP2M1. Activates Wnt signaling.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the SGC-AAK1-1 probe summary on the SGC website.

Technical Data

M. Wt 427.52
Formula C21H25N5O3S
Storage Store at -20°C
Purity ≥98% (HPLC)
Smiles O=C(NC1=NNC2=C1C=CC(C3=CC=CC(NS(=O)(N(CC)CC)=O)=C3)=C2)C4CC4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 42.75 100

Preparing Stock Solutions

The following data is based on the product molecular weight 427.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.34 mL 11.7 mL 23.39 mL
5 mM 0.47 mL 2.34 mL 4.68 mL
10 mM 0.23 mL 1.17 mL 2.34 mL
50 mM 0.05 mL 0.23 mL 0.47 mL

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References

References are publications that support the biological activity of the product.

Agajanian et al (2018) AAK1 inhibits WNT signaling by promoting clathrin-mediated endocytosis of LRP6. View prepublication manuscript.


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