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SGC AAK1 1
Biological Activity for SGC AAK1 1
SGC AAK1 1 is an adaptor-associated protein kinase 1 (AAK1) and BMP-2-inducible protein kinase (BMP2K) inhibitor (IC50 values are 233 nM and 1.48 μM for AAK1 and BMP2K, respectively). Inhibits AAK1-dependent phosphorylation of AP2M1. Activates Wnt signaling.
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the SGC-AAK1-1 probe summary on the SGC website.
Compound Libraries for SGC AAK1 1
Technical Data for SGC AAK1 1
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for SGC AAK1 1
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for SGC AAK1 1
The following data is based on the product molecular weight 427.52. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.34 mL||11.7 mL||23.39 mL|
|5 mM||0.47 mL||2.34 mL||4.68 mL|
|10 mM||0.23 mL||1.17 mL||2.34 mL|
|50 mM||0.05 mL||0.23 mL||0.47 mL|
References for SGC AAK1 1
References are publications that support the biological activity of the product.
Agajanian et al (2019) WNT Activates the AAK1 Kinase to Promote Clathrin-Mediated Endocytosis of LRP6 and Establish a Negative Feedback Loop. Cell Rep. 26 79 PMID: 30605688
If you know of a relevant reference for SGC AAK1 1, please let us know.
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Citations for SGC AAK1 1
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Literature in this Area
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