SEN 1269

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Cat.No. 4699 - SEN 1269 | CAS No. 956128-01-1
Description: Amyloid-β aggregation inhibitor
Chemical Name: 3-[[5-[3-(Dimethylamino)phenoxy]-2-pyrimidinyl]amino]phenol
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Amyloid-β (Aβ) aggregation inhibitor; blocks Aβ(1-42) aggregation and protects neuronal cell lines exposed to Aβ(1-42). Reduces Aβ oligomer-induced LTP and memory deficits in vivo.

Compound Libraries

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Technical Data

M. Wt 322.36
Formula C18H18N4O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 956128-01-1
PubChem ID 46835756
InChI Key MFPAAKZZUIRMKR-UHFFFAOYSA-N
Smiles OC1=CC(NC2=NC=C(OC3=CC=CC(N(C)C)=C3)C=N2)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 32.24 100
ethanol 16.12 50

Preparing Stock Solutions

The following data is based on the product molecular weight 322.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.1 mL 15.51 mL 31.02 mL
5 mM 0.62 mL 3.1 mL 6.2 mL
10 mM 0.31 mL 1.55 mL 3.1 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

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Reconstitution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Scopes et al (2012) Aβ oligomer toxicity inhibitor protects memory in models of synaptic toxicity. Br.J.Pharmacol. 167 383 PMID: 22913627


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Keywords: SEN1269 Amyloid-β (Aβ) aggregation inhibitors inhibits LTP memory Alzheimer's amyloidbeta amyloidb Amyloid Beta Peptides

Citations for SEN 1269

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Literature in this Area

Neurodegeneration

Neurodegeneration Product Guide

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Alzheimer's

Alzheimer's Poster

Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.

Pathways for SEN 1269

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