SDM25N hydrochloride

Discontinued Product

SDM25N hydrochloride (Cat. No. 1410) has been withdrawn from sale for commercial reasons.
Cat.No. 1410 - SDM25N hydrochloride | C26H26N2O3.HCl | CAS No. 342884-71-3
Description: High affinity and selective non-peptide δ antagonist; also inhibits dengue virus replication
Chemical Name: (4bS,8R,8aS,14bR)-5,6,7,8,14,14b-Hexahydro-7-(2-methyl-2-propenyl)-4,8-methanobenzofuro[2,3-a]pyrido[4,3-b]carbazole-1,8a(9H)-diol hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (3)
Reviews
Literature (5)

Biological Activity

High affinity and highly selective non-peptide δ receptor antagonist (Ki values are 4.7, 3800 and 7900 nM for δ, κ and μ receptors respectively). More selective than naltrindole (Cat. No. 0740). Also inhibits Dengue virus replication.

Compound Libraries

SDM25N hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 450.96
Formula C26H26N2O3.HCl
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 342884-71-3
PubChem ID 90479789
InChI Key QLLCUVACGPLGAX-IDRHMUJXSA-N
Smiles Cl.[H][C@@]12OC3=C(O)C=CC4=C3[C@@]11CCN(CC(C)=C)[C@]([H])(C4)[C@]1(O)CC1=C2NC2=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

Certificate of Analysis / Product Datasheet
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Keywords: SDM25N hydrochloride, SDM25N hydrochloride supplier, Potent, selective, non-peptide, δ-opioid, delta-opioid, antagonist, DOP, Receptors, OP1, dengue, virus, antiviral, Delta, Opioid, Flaviviruses, 1410, Tocris Bioscience

3 Citations for SDM25N hydrochloride

Citations are publications that use Tocris products. Selected citations for SDM25N hydrochloride include:

Sprokholt et al (2017) RIG-I-like receptor triggering by Dengue virus drives dendritic cell immune activation and TH1 differentiation. J.Immunol. 198 4764 PMID: 28507028

van Cleef et al (2013) Identification of a new dengue virus inhibitor that targets the viral NS4B protein and restricts genomic RNA replication. Antiviral Res. 99 165 PMID: 23735301

Ong et al (2015) Prolonged mor. treatment alters δ opioid receptor post-internalization trafficking. Br J Pharmacol 172 615 PMID: 24819092


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