SDM25N hydrochloride

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Cat.No. 1410 - SDM25N hydrochloride | C26H26N2O3.HCl | CAS No. 342884-71-3
Description: Potent, selective non-peptide δ antagonist; also inhibits dengue virus replication
Chemical Name: (4bS,8R,8aS,14bR)-5,6,7,8,14,14b-Hexahydro-7-(2-methyl-2-propenyl)-4,8-methanobenzofuro[2,3-a]pyrido[4,3-b]carbazole-1,8a(9H)-diol hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

Potent and highly selective non-peptide δ receptor antagonist (Ki values are 4.7, 3800 and 7900 nM for δ, κ and μ receptors respectively). More selective than naltrindole (Cat. No. 0740). Also inhibits Dengue virus replication.

Compound Libraries

SDM25N hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 450.96
Formula C26H26N2O3.HCl
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 342884-71-3
PubChem ID 90479789
InChI Key QLLCUVACGPLGAX-XXCZMEBESA-N
Smiles O[C@@]24[C@]3([C@@H]7C(N6)=C(C5=C6C=CC=C5)C4)C1=C(O7)C(O)=CC=C1CC2N(CC(C)=C)CC3.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 45.09 100
ethanol 45.09 100
water 4.5 10

Preparing Stock Solutions

The following data is based on the product molecular weight 450.96. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.22 mL 11.09 mL 22.17 mL
5 mM 0.44 mL 2.22 mL 4.43 mL
10 mM 0.22 mL 1.11 mL 2.22 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

McLamore et al (2001) Effect of N-alkyl and N-alkenyl substituents in noroxymorphindole, 17-substituted-6,7-dehydro-4,5α-epoxy-3,14-dihydroxy-6,7:2 ',3 '-indolomorphinans, on opioid receptor affinity, selectivity, and efficacy. J.Med.Chem. 44 1471 PMID: 11311071

Sprokholt et al (2017) RIG-I-like receptor triggering by Dengue virus drives dendritic cell immune activation and TH1 differentiation. J.Immunol. PMID: 28507028


If you know of a relevant reference for SDM25N hydrochloride, please let us know.

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View all δ Opioid Receptor Antagonists

Keywords: Potent selective non-peptide δ-opioid delta-opioid antagonist DOP Receptors OP1 dengue virus antiviral Delta Opioid Receptors

2 Citations for SDM25N hydrochloride

Citations are publications that use Tocris products. Selected citations for SDM25N hydrochloride include:

Sprokholt et al (2017) RIG-I-like receptor triggering by Dengue virus drives dendritic cell immune activation and TH1 differentiation. J.Immunol. PMID: 28507028

Ong et al (2015) Prolonged morphine treatment alters δ opioid receptor post-internalization trafficking. Br J Pharmacol 172 615 PMID: 24819092


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