SDM25N hydrochloride

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Cat.No. 1410 - SDM25N hydrochloride | C26H26N2O3.HCl | CAS No. 342884-71-3
Description: High affinity and selective non-peptide δ antagonist; also inhibits dengue virus replication
Chemical Name: (4bS,8R,8aS,14bR)-5,6,7,8,14,14b-Hexahydro-7-(2-methyl-2-propenyl)-4,8-methanobenzofuro[2,3-a]pyrido[4,3-b]carbazole-1,8a(9H)-diol hydrochloride
Purity: ≥99% (HPLC)
Citations (3)
Literature (5)

Biological Activity

High affinity and highly selective non-peptide δ receptor antagonist (Ki values are 4.7, 3800 and 7900 nM for δ, κ and μ receptors respectively). More selective than naltrindole (Cat. No. 0740). Also inhibits Dengue virus replication.

Compound Libraries

SDM25N hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 450.96
Formula C26H26N2O3.HCl
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 342884-71-3
PubChem ID 90479789
Smiles Cl.[H][C@@]12OC3=C(O)C=CC4=C3[C@@]11CCN(CC(C)=C)[C@]([H])(C4)[C@]1(O)CC1=C2NC2=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 4.5 10
DMSO 45.09 100

Preparing Stock Solutions

The following data is based on the product molecular weight 450.96. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.22 mL 11.09 mL 22.17 mL
5 mM 0.44 mL 2.22 mL 4.43 mL
10 mM 0.22 mL 1.11 mL 2.22 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the biological activity of the product.

McLamore et al (2001) Effect of N-alkyl and N-alkenyl substituents in noroxymorphindole, 17-substituted-6,7-dehydro-4,5α-epoxy-3,14-dihydroxy-6,7:2 ',3 '-indolomorphinans, on opioid receptor affinity, selectivity, and efficacy. J.Med.Chem. 44 1471 PMID: 11311071

Sprokholt et al (2017) RIG-I-like receptor triggering by Dengue virus drives dendritic cell immune activation and TH1 differentiation. J.Immunol. PMID: 28507028

If you know of a relevant reference for SDM25N hydrochloride, please let us know.

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View all δ Opioid Receptor Antagonists

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3 Citations for SDM25N hydrochloride

Citations are publications that use Tocris products. Selected citations for SDM25N hydrochloride include:

Ong et al (2015) Prolonged mor. treatment alters δ opioid receptor post-internalization trafficking. Br J Pharmacol 172 615 PMID: 24819092

van Cleef et al (2013) Identification of a new dengue virus inhibitor that targets the viral NS4B protein and restricts genomic RNA replication. Antiviral Res. 99 165 PMID: 23735301

Sprokholt et al (2017) RIG-I-like receptor triggering by Dengue virus drives dendritic cell immune activation and TH1 differentiation. J.Immunol. 198 4764 PMID: 28507028

Do you know of a great paper that uses SDM25N hydrochloride from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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