SD 208

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Description: Potent ATP-competitive TGF-βRI inhibitor
Chemical Name: 2-(5-Chloro-2-fluorophenyl)-4-[(4-pyridyl)amino]pteridine
Purity: ≥98% (HPLC)
Datasheet
Citations (10)
Reviews
Literature (3)
Pathways (1)

Biological Activity for SD 208

SD 208 is a potent, orally active ATP-competitive transforming growth factor-β receptor 1 (TGF-βRI) inhibitor (IC50 = 49 nM). Displays > 100-fold and > 17-fold selectivity over TGF-βRII and other common kinases respectively. Exhibits anti-inflammatory and antitumor activity. Also promotes an antiglioma immune response. Ameliorates germinal matrix hemorrhage-induced neurological deficits in neonatal rats.

Compound Libraries for SD 208

SD 208 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for SD 208

M. Wt 352.75
Formula C17H10ClFN6
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 627536-09-8
PubChem ID 10316032
InChI Key BERLXWPRSBJFHO-UHFFFAOYSA-N
Smiles FC(C=CC(Cl)=C3)=C3C2=NC1=NC=CN=C1C(NC4=CC=NC=C4)=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SD 208

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 7.05 20 with gentle warming

Preparing Stock Solutions for SD 208

The following data is based on the product molecular weight 352.75. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 14.17 mL 70.87 mL 141.74 mL
1 mM 2.83 mL 14.17 mL 28.35 mL
2 mM 1.42 mL 7.09 mL 14.17 mL
10 mM 0.28 mL 1.42 mL 2.83 mL

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Product Datasheets for SD 208

Certificate of Analysis / Product Datasheet
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View Related Products by Product Action

View all TGF-β Receptor Inhibitors

Keywords: SD 208, SD 208 supplier, Potent, ATP-competitive, TGF-βRI, TGF-β, TGF-betaRI, TGFbRI, TGFbR1, tgf-b1inhibitors, inhibits, Transforming, Growth, Factors, Beta, Receptors, TGF-beta, Serine/Threonine, Kinases, RSTKs, SD208, 3269, Tocris Bioscience

10 Citations for SD 208

Citations are publications that use Tocris products. Selected citations for SD 208 include:

Nistala et al (2010) Differential effects of alendr. and los. therapy on osteopenia and aortic aneurysm in mice with severe Marfan syndrome. PLoS One 19 4790 PMID: 20871099

Geyh et al (2018) Transforming growth factor β1-mediated functional inhibition of mesenchymal stromal cells in myelodysplastic syndromes and acute myeloid leukemia. Haematologica 103 1462 PMID: 29773599

Clements et al (2017) The Wound Microenvironment Reprograms Schwann Cells to Invasive Mesenchymal-like Cells to Drive Peripheral Nerve Regeneration. Neuron 96 98 PMID: 28957681

Li and Gotlieb (2011) Transforming growth factor-β regulates the growth of valve interstitial cells in vitro. Am J Pathol 179 1746 PMID: 21851806


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Reviews for SD 208

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Stem Cell Research Product Guide

Stem Cell Research Product Guide

This product guide provides a background to the use of small molecules in stem cell research and lists over 200 products for use in:

  • Self-renewal and Maintenance
  • Differentiation
  • Reprogramming
  • Organoid Generation
  • GMP and Ancillary Material Grade Products
Stem Cells Scientific Review

Stem Cells Scientific Review

Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.

Stem Cells Poster

Stem Cells Poster

Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.

Pathways for SD 208

TGF-β Signaling Pathway

TGF-β Signaling Pathway

The TGF-β signaling pathway is involved in the regulation of growth and proliferation of cells along with migration, differentiation and apoptosis.