SCOTfluor lactic acid probe 510

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Description: Fluorescent lactic acid probe
Chemical Name: (2S)-2-Hydroxy-3-[(7-nitro-2,1,3-benzoselenadiazol-4-yl)amino]propanoic acid
Purity: ≥95% (HPLC)
Reviews (1)
Literature (1)

Biological Activity for SCOTfluor lactic acid probe 510

SCOTfluor lactic acid probe 510 is a red fluorescent probe for imaging lactic acid metabolism in vivo. Excitation and emission maxima (λ) are 485 and 605 nm, respectively. Suitable for use with flow cytometry and super-resolution microscopy.

Scientific Data

Fluorescence Imaging Application of SCOTfluor lactic acid probe 510 in HeLa cells View Larger

Application of SCOTfluor lactic acid probe 510 in HeLa cells. TIRF microscopy image (left) of HeLa cells after incubation with SCOTfluor 510 lactate (100 μM). Multi-tracking of fluorescent particles corresponding to SCOTfluor 510 lactate labelling (right). Scale: 5 μm. Image kindly provided by Prof. Marc Vendrell, acquired by Dr Mathew Horrocks, School of Chemistry, University of Edinburgh.

Licensing Information

Sold under license from the University of Edinburgh

Optical Data for SCOTfluor lactic acid probe 510

SCOTfluor lactic acid probe 510 Dye Spectra
Emission Color Orange
λabs 485 nm
λem 605 nm
Closest Laser line 488 nm
Cell Permeable Yes
Application Fluorescence Microscopy, Super Resolution Microscopy (SRM), Flow Cytometry, in vivo

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Technical Data for SCOTfluor lactic acid probe 510

M. Wt 331.15
Formula C9H8N4O5Se
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 2351933-31-6
PubChem ID 146168509
Smiles O[C@H](C(O)=O)CNC1=CC=C(N(=O)=O)C2=N[Se]N=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SCOTfluor lactic acid probe 510

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 3.31 10

Preparing Stock Solutions for SCOTfluor lactic acid probe 510

The following data is based on the product molecular weight 331.15. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 30.2 mL 150.99 mL 301.98 mL
0.5 mM 6.04 mL 30.2 mL 60.4 mL
1 mM 3.02 mL 15.1 mL 30.2 mL
5 mM 0.6 mL 3.02 mL 6.04 mL

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Product Datasheets for SCOTfluor lactic acid probe 510

References for SCOTfluor lactic acid probe 510

References are publications that support the biological activity of the product.

Benson et al (2019) SCOTfluors: Small, conjugatable, orthogonal, and tunable fluorophores for in vivo imaging of cell metabolism. Angew.Chem Int.Ed.Engl. 58 6911 PMID: 30924239

Monsorno et al (2023) Loss of microglial MCT4 leads to defective synaptic pruning and anxiety-like behavior in mice. Nat.Commun. 14 5749 PMID: 37717033

If you know of a relevant reference for SCOTfluor lactic acid probe 510, please let us know.

Keywords: SCOTfluor lactic acid probe 510, SCOTfluor lactic acid probe 510 supplier, metabolism, imaging, lactic, acid, fluorophore, fluorescent, in, vivo, Other, Fluorescent, Probes, 7448, Tocris Bioscience

Citations for SCOTfluor lactic acid probe 510

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Reviews for SCOTfluor lactic acid probe 510

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Good signal SCOTfluor lactic acid probe.
By Anonymous on 03/07/2024
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: 293T

Primary cultured cells were pre-treated for 2 h with either control or with low glucose-containing medium. The SCOTfluor lactate was diluted in control or low glucose-medium to a concentration of 0.1 mM and applied onto cells for 1 h. Imaging was performed using a stage incubator and flow-cyto. Treament showed that lactate upregulated

review image

Literature in this Area

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