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Biological Activity for SC 66
SC 66 is an allosteric inhibitor of Akt; interferes with pleckstrin homology domain binding to PIP3 and facilitates Akt ubiquitination. Exhibits anticancer activity in vitro and in vivo.
Technical Data for SC 66
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for SC 66
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for SC 66
The following data is based on the product molecular weight 276.33. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.75 mM||4.83 mL||24.13 mL||48.25 mL|
|3.75 mM||0.97 mL||4.83 mL||9.65 mL|
|7.5 mM||0.48 mL||2.41 mL||4.83 mL|
|37.5 mM||0.1 mL||0.48 mL||0.97 mL|
References for SC 66
References are publications that support the biological activity of the product.
Jo et al (2011) Deactivation of Akt by a small molecule inhibitor targeting pleckstrin homology domain and facilitating Akt ubiquitination. Proc.Natl.Acad.Sci.USA 108 6486 PMID: 21464312
If you know of a relevant reference for SC 66, please let us know.
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Keywords: SC 66, SC 66 supplier, SC66, akt, pkb, protein, kinase, b, inhibitors, inhibits, allosteric, dual, activity, inhibitory, Akt, (Protein, Kinase, B), Protein, B/Akt, 4398, Tocris Bioscience
2 Citations for SC 66
Citations are publications that use Tocris products. Selected citations for SC 66 include:
Hung et al (2015) p22phox confers resistance to cisplatin, by blocking its entry into the nucleus. J Cell Biol 6 4110 PMID: 25686830
Deng et al (2018) HPV16-Immortalized Cells from Human Transformation Zone and Endocervix are More Dysplastic than Ectocervical Cells in Organotypic Culture. Sci Rep 8 15402 PMID: 30337615
Do you know of a great paper that uses SC 66 from Tocris? Please let us know.
Reviews for SC 66
Average Rating: 5 (Based on 1 Review.)
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MG-63 cells were treated with LPA (10 µM) alone or in the presence of SC 66 (0-10 µM) for 3 h to follow COX-2 expression using Western blot. SC 66 inhibited LPA-induced COX-2 expression in a concentration dependent manner starting from 5 µM.
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.