SC 66

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Cat.No. 4398 - SC 66 | C18H16N2O | CAS No. 871361-88-5
Description: Allosteric Akt inhibitor
Chemical Name: (2E,6E)-2,6-Bis(4-pyridinylmethylene)cyclohexanone
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature
Pathways

Biological Activity

Allosteric inhibitor of Akt; interferes with pleckstrin homology domain binding to PIP3 and facilitates Akt ubiquitination. Exhibits anticancer activity in vitro and in vivo.

Technical Data

M. Wt 276.33
Formula C18H16N2O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 871361-88-5
PubChem ID 6018993
InChI Key CYVVJSKZRBZHAV-UNZYHPAISA-N
Smiles O=C(/C(CCC3)=C/C2=CC=NC=C2)/C3=C/C1=CC=NC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 20.72 75
ethanol 20.72 75

Preparing Stock Solutions

The following data is based on the product molecular weight 276.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.62 mL 18.09 mL 36.19 mL
5 mM 0.72 mL 3.62 mL 7.24 mL
10 mM 0.36 mL 1.81 mL 3.62 mL
50 mM 0.07 mL 0.36 mL 0.72 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Jo et al (2011) Deactivation of Akt by a small molecule inhibitor targeting pleckstrin homology domain and facilitating Akt ubiquitination. Proc.Natl.Acad.Sci.USA 108 6486 PMID: 21464312


If you know of a relevant reference for SC 66, please let us know.

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View all Akt (Protein Kinase B) Inhibitors

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1 Citation for SC 66

Citations are publications that use Tocris products. Selected citations for SC 66 include:

Hung et al (2015) p22phox confers resistance to cisplatin, by blocking its entry into the nucleus. J Cell Biol 6 4110 PMID: 25686830


Do you know of a great paper that uses SC 66 from Tocris? If so please let us know.

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Reviews

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases
Schizophrenia

Schizophrenia Poster

Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.

Pathways for SC 66

Akt

Akt Signaling Pathway

The Akt signaling pathway plays a key role in the mediation of protein synthesis, metabolism, proliferation and cell cycle progression. It may be referred to as a 'prosurvival' pathway.

Protocols

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