SC 66

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Cat.No. 4398 - SC 66 | C18H16N2O | CAS No. 871361-88-5
Description: Allosteric Akt inhibitor
Chemical Name: (2E,6E)-2,6-Bis(4-pyridinylmethylene)cyclohexanone
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews (1)
Literature
Pathways

Biological Activity

Allosteric inhibitor of Akt; interferes with pleckstrin homology domain binding to PIP3 and facilitates Akt ubiquitination. Exhibits anticancer activity in vitro and in vivo.

Technical Data

M. Wt 276.33
Formula C18H16N2O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 871361-88-5
PubChem ID 6018993
InChI Key CYVVJSKZRBZHAV-UNZYHPAISA-N
Smiles O=C(/C(CCC3)=C/C2=CC=NC=C2)/C3=C/C1=CC=NC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 20.72 75
ethanol 20.72 75

Preparing Stock Solutions

The following data is based on the product molecular weight 276.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.75 mM 4.83 mL 24.13 mL 48.25 mL
3.75 mM 0.97 mL 4.83 mL 9.65 mL
7.5 mM 0.48 mL 2.41 mL 4.83 mL
37.5 mM 0.1 mL 0.48 mL 0.97 mL

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References

References are publications that support the biological activity of the product.

Jo et al (2011) Deactivation of Akt by a small molecule inhibitor targeting pleckstrin homology domain and facilitating Akt ubiquitination. Proc.Natl.Acad.Sci.USA 108 6486 PMID: 21464312


If you know of a relevant reference for SC 66, please let us know.

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Keywords: SC 66, SC 66 supplier, SC66, akt, pkb, protein, kinase, b, inhibitors, inhibits, allosteric, dual, activity, inhibitory, Akt, (Protein, Kinase, B), Protein, B/Akt, 4398, Tocris Bioscience

1 Citation for SC 66

Citations are publications that use Tocris products. Selected citations for SC 66 include:

Hung et al (2015) p22phox confers resistance to cisplatin, by blocking its entry into the nucleus. J Cell Biol 6 4110 PMID: 25686830


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Reviews for SC 66

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SC 66 inhibits LPA induced COX-2 in osteosarcoma cells: Excellent publishable, performed ideally.
By Christopher Trummer on 10/23/2018
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: Osteosarcoma

MG-63 cells were treated with LPA (10 µM) alone or in the presence of SC 66 (0-10 µM) for 3 h to follow COX-2 expression using Western blot. SC 66 inhibited LPA-induced COX-2 expression in a concentration dependent manner starting from 5 µM.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

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  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases
Schizophrenia

Schizophrenia Poster

Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.

Pathways for SC 66

Akt

Akt Signaling Pathway

The Akt signaling pathway plays a key role in the mediation of protein synthesis, metabolism, proliferation and cell cycle progression. It may be referred to as a 'prosurvival' pathway.