SB 221284

Discontinued Product

SB 221284 (Cat. No. 1379) has been withdrawn from sale for commercial reasons.
Description: Potent and selective 5-HT2B and 5-HT2C antagonist
Chemical Name: 2,3-Dihydro-5-(methylthio)-N-3-pyridinyl-6-(trifluoromethyl)-1H-indole-1-carboxamide
Purity: ≥99% (HPLC)
Literature (3)

Biological Activity for SB 221284

SB 221284 is a potent, selective 5-HT2C/2B receptor antagonist. pKi values are 6.4, 7.9 and 8.6 for 5-HT2A, 2B and 2C receptors respectively. Centrally active upon systemic administration in vivo.

Licensing Information

Sold under license

Technical Data for SB 221284

M. Wt 353.36
Formula C16H14F3N3OS
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 196965-14-7
PubChem ID 443389
Smiles CSC1=C(C=C2N(CCC2=C1)C(=O)NC1=CC=CN=C1)C(F)(F)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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Keywords: SB 221284, SB 221284 supplier, Potent, selective, 5-HT2C, antagonists, Serotonin, Receptors, 5-HT2B, SB221284, 1379, Tocris Bioscience

Citations for SB 221284

Citations are publications that use Tocris products.

Currently there are no citations for SB 221284.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

5-HT Receptors Scientific Review

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

Parkinson's Disease Poster

Parkinson's Disease Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.