SB 205384

Discontinued Product

SB 205384 (Cat. No. 1512) has been withdrawn from sale for commercial reasons.
Description: GABAA modulator; slows current decay
Chemical Name: 4-Amino-5,6,7,8-tetrahydro-7-hydroxy-2-methyl-[1H]benzothieno[2,3-b]pyridine-3-carboxylic acid 2-butynyl ester
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews
Literature (2)

Biological Activity for SB 205384

SB 205384 is a GABAA receptor modulator; slows current decay. Potentiates α6, α3 and α5-subunit-containing receptors (EC50 values are 280, 695 and 730 nM respectively). Displays little effect on receptors containing α1 or α2 subunits.

Technical Data for SB 205384

M. Wt 330.4
Formula C17H18N2O3S
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 160296-13-9
PubChem ID 197690
InChI Key JDTZAGLGBRRCJT-UHFFFAOYSA-N
Smiles CC#CCOC(=O)C1=C(C)N=C2SC3=C(CCC(O)C3)C2=C1N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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Keywords: SB 205384, SB 205384 supplier, GABAA, receptor, modulators, slows, current, decay, Receptors, SB205384, 1512, Tocris Bioscience

2 Citations for SB 205384

Citations are publications that use Tocris products. Selected citations for SB 205384 include:

Heidelberg et al (2013) SB-205384 is a positive allosteric modulator of recombinant GABAA receptors containing rat α3, α5, or α6 subunit subtypes coexpressed with β3 and γ2 subunits. J Pharmacol Exp Ther 347 235 PMID: 23902941

Miller et al (2010) Quantitative trait locus analysis identifies Gabra3 as a regulator of behavioral despair in mice. Sci Rep 21 247 PMID: 20512339


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


GABA Receptors Scientific Review

GABA Receptors Scientific Review

Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.

Addiction Poster

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.