SB 200646 hydrochloride

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Cat.No. 1371 - SB 200646 hydrochloride | C15H14N4O.HCl | CAS No. 143797-62-0
Description: 5-HT2C/2B antagonist
Chemical Name: N-(1-Methyl-1H-indol-5-yl)-N'-3-pyridinylurea
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

5-HT2C/2B receptor antagonist, selective over 5-HT1A. Affinities are 7.4 (pA2), 6.9 (pKi) and 5.2 (pKi) for 5-HT2B, 2C and 2A respectively. Orally active in vivo.

Licensing Information

Sold under license

Compound Libraries

SB 200646 hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 302.76
Formula C15H14N4O.HCl
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 143797-62-0
PubChem ID 5311422
InChI Key IGRYPUQJEDJLHC-UHFFFAOYSA-N
Smiles Cl.CN1C=CC2=CC(NC(=O)NC3=CN=CC=C3)=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.28 100

Preparing Stock Solutions

The following data is based on the product molecular weight 302.76. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.3 mL 16.51 mL 33.03 mL
5 mM 0.66 mL 3.3 mL 6.61 mL
10 mM 0.33 mL 1.65 mL 3.3 mL
50 mM 0.07 mL 0.33 mL 0.66 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Forbes et al (1993) N-(1-Methyl-5-indolyl)-N'-(3-pyridyl)urea hydrochloride: the first selective 5-HT1C receptor antagonist. J.Med.Chem. 36 1104 PMID: 8478907

Kennett et al (1994) In vivo properties of SB 200646A, a 5-HT2C/2B recepor antagonist. Br.J.Pharmacol. 111 797 PMID: 7912626

Kennett et al (1995) Effect of SB 200646A, a 5-HT2C/5-HT2B receptor antagonist, in two conflict models of anxiety. Psychopharmacology (Berl.) 118 178 PMID: 7617805


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1 Citation for SB 200646 hydrochloride

Citations are publications that use Tocris products. Selected citations for SB 200646 hydrochloride include:

Xiao et al (2008) Release of glutamate and CGRP from trigeminal ganglion neurons: Role of calcium channels and 5-HT1 receptor signaling. Am J Physiol Endocrinol Metab 4 12 PMID: 18416824


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