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Submit ReviewSB 200646 hydrochloride
Description: 5-HT2C/2B antagonist
Chemical Name: N-(1-Methyl-1H-indol-5-yl)-N'-3-pyridinylurea
Purity: ≥98% (HPLC)
Biological Activity for SB 200646 hydrochloride
SB 200646 hydrochloride is a 5-HT2C/2B receptor antagonist, selective over 5-HT1A. Affinities are 7.4 (pA2), 6.9 (pKi) and 5.2 (pKi) for 5-HT2B, 2C and 2A respectively. Orally active in vivo.
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Sold under license
Technical Data for SB 200646 hydrochloride
| M. Wt | 302.76 |
| Formula | C15H14N4O.HCl |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 143797-62-0 |
| PubChem ID | 5311422 |
| InChI Key | IGRYPUQJEDJLHC-UHFFFAOYSA-N |
| Smiles | Cl.CN1C=CC2=CC(NC(=O)NC3=CN=CC=C3)=CC=C12 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for SB 200646 hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 30.28 | 100 |
Preparing Stock Solutions for SB 200646 hydrochloride
The following data is based on the product molecular weight 302.76. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.3 mL | 16.51 mL | 33.03 mL |
| 5 mM | 0.66 mL | 3.3 mL | 6.61 mL |
| 10 mM | 0.33 mL | 1.65 mL | 3.3 mL |
| 50 mM | 0.07 mL | 0.33 mL | 0.66 mL |
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Product Datasheets for SB 200646 hydrochloride
References for SB 200646 hydrochloride
References are publications that support the biological activity of the product.
Forbes et al (1993) N-(1-Methyl-5-indolyl)-N'-(3-pyridyl)urea hydrochloride: the first selective 5-HT1C receptor antagonist. J.Med.Chem. 36 1104 PMID: 8478907
Kennett et al (1994) In vivo properties of SB 200646A, a 5-HT2C/2B recepor antagonist. Br.J.Pharmacol. 111 797 PMID: 7912626
Kennett et al (1995) Effect of SB 200646A, a 5-HT2C/5-HT2B receptor antagonist, in two conflict models of anxiety. Psychopharmacology (Berl.) 118 178 PMID: 7617805
If you know of a relevant reference for SB 200646 hydrochloride, please let us know.
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1 Citation for SB 200646 hydrochloride
Citations are publications that use Tocris products. Selected citations for SB 200646 hydrochloride include:
Xiao et al (2008) Release of glutamate and CGRP from trigeminal ganglion neurons: Role of calcium channels and 5-HT1 receptor signaling. Am J Physiol Endocrinol Metab 4 12 PMID: 18416824
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