Salvinorin A

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Cat.No. 2134 - Salvinorin A | C23H28O8 | CAS No. 83729-01-5
Description: Highly potent and selective κ agonist
Alternative Names: Divinorin A
Chemical Name: (2S,4aR,6aR,7R,9S,10aS,10bR)-9-(Acetyloxy)-2-(3-furanyl)dodecahydro-6a,10b-dimethyl-4,10-dioxo-2H-naphtho[2,1-c]pyran-7-carboxylic acid methyl ester
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Potent naturally occuring non-nitrogenous κ-opioid selective agonist that displays high affinity at both native (Ki = 4.3 nM) and cloned (Ki = 16 nM) κ-opioid receptors. Also exhibits allosteric modulation of μ-opioid receptor binding. Reported to be brain-penetrant and displays psychoactive properties. .

Technical Data

M. Wt 432.47
Formula C23H28O8
Storage Desiccate at -20°C
Purity ≥98% (HPLC)
CAS Number 83729-01-5
PubChem ID 128563
InChI Key OBSYBRPAKCASQB-AGQYDFLVSA-N
Smiles O=C3[C@]2([H])CC[C@@]([C@]([H])1[C@](C)2C[C@@H]([C@]4=COC=C4)O3)(C)[C@H]([C@@](OC)=O)C[C@H](OC(C)=O)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 4.32 10

Preparing Stock Solutions

The following data is based on the product molecular weight 432.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.31 mL 11.56 mL 23.12 mL
5 mM 0.46 mL 2.31 mL 4.62 mL
10 mM 0.23 mL 1.16 mL 2.31 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Rothman et al (2007) Salvinorin A: allosteric interactions at the μ-opioid receptor. J.Pharmacol.Exp.Ther. 320 801 PMID: 17060492

Roth et al (2002) Salvinorin A: a potent naturally occuring nonnitrogenous κ opioid selective agonist. Proc.Natl.Acad.Sci.USA 99 11934 PMID:

Scheffler and Roth (2003) Salvinorin A: the 'magic mint' hallucinogen finds a molecular target in the kappa opioid receptor. TiPS. 24 107 PMID:


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View all κ Opioid Receptor Agonists

Keywords: potent selective κ-opioid kappa-opioid agonists KOP Receptors OP2 SalvinorinA DivinorinA Divinorin A Kappa Opioid Receptors

1 Citation for Salvinorin A

Citations are publications that use Tocris products. Selected citations for Salvinorin A include:

Mundra et al (2012) Naltrindole inhibits human multiple myeloma cell proliferation in vitro and in a murine xenograft model in vivo. J Pharmacol Exp Ther 342 273 PMID: 22537770


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