Potent naturally occuring non-nitrogenous κ-opioid selective agonist that displays high affinity at both native (Ki = 4.3 nM) and cloned (Ki = 16 nM) κ-opioid receptors. Also exhibits allosteric modulation of μ-opioid receptor binding. Reported to be brain-penetrant and displays psychoactive properties. .
External Portal Information
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of Salvinorin A is reviewed on the chemical probes website.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 432.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.31 mL||11.56 mL||23.12 mL|
|5 mM||0.46 mL||2.31 mL||4.62 mL|
|10 mM||0.23 mL||1.16 mL||2.31 mL|
|50 mM||0.05 mL||0.23 mL||0.46 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Rothman et al (2007) Salvinorin A: allosteric interactions at the μ-opioid receptor. J.Pharmacol.Exp.Ther. 320 801 PMID: 17060492
If you know of a relevant reference for Salvinorin A, please let us know.
View Related Products by Product Action
Keywords: Salvinorin A, supplier, potent, selective, κ-opioid, kappa-opioid, agonists, KOP, Receptors, OP2, SalvinorinA, DivinorinA, Divinorin, A, Kappa, Opioid, Receptors, Tocris Bioscience
1 Citation for Salvinorin A
Citations are publications that use Tocris products. Selected citations for Salvinorin A include:
Mundra et al (2012) Naltrindole inhibits human multiple myeloma cell proliferation in vitro and in a murine xenograft model in vivo. J Pharmacol Exp Ther 342 273 PMID: 22537770
Do you know of a great paper that uses Salvinorin A from Tocris? If so please let us know.
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