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Discontinued ProductSalvinorin A (Cat. No. 2134) has been withdrawn from sale for commercial reasons.
Biological Activity for Salvinorin A
Salvinorin A is a potent naturally occuring non-nitrogenous κ-opioid selective agonist that displays high affinity at both native (Ki = 4.3 nM) and cloned (Ki = 16 nM) κ-opioid receptors. Also exhibits allosteric modulation of μ-opioid receptor binding. Reported to be brain-penetrant and displays psychoactive properties..
External Portal Information for Salvinorin A
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of Salvinorin A is reviewed on the chemical probes website.
Technical Data for Salvinorin A
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References for Salvinorin A
References are publications that support the biological activity of the product.
Rothman et al (2007) Salvinorin A: allosteric interactions at the μ-opioid receptor. J.Pharmacol.Exp.Ther. 320 801 PMID: 17060492
Roth et al (2002) Salvinorin A: a potent naturally occuring nonnitrogenous κ opioid selective agonist. Proc.Natl.Acad.Sci.USA 99 11934
Scheffler and Roth (2003) Salvinorin A: the 'magic mint' hallucinogen finds a molecular target in the kappa opioid receptor. TiPS. 24 107
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Keywords: Salvinorin A, Salvinorin A supplier, potent, selective, κ-opioid, kappa-opioid, agonists, KOP, Receptors, OP2, SalvinorinA, DivinorinA, Divinorin, A, Kappa, Opioid, 2134, Tocris Bioscience
3 Citations for Salvinorin A
Citations are publications that use Tocris products. Selected citations for Salvinorin A include:
Braida et al (2009) Potential anxiolytic- and antidepressant-like effects of salvinorin A, the main active ingredient of Salvia divinorum, in rodents. Br J Pharmacol 157 844 PMID: 19422370
Coffeen et al (2018) Salvinorin A reduces neuropathic nociception in the insular cortex of the rat. Eur.J.Pain. 22 311 PMID: 28975684
Mundra et al (2012) Naltrindole inhibits human multiple myeloma cell proliferation in vitro and in a murine xenograft model in vivo. J Pharmacol Exp Ther 342 273 PMID: 22537770
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.