Salvinorin A

Discontinued Product

Salvinorin A (Cat. No. 2134) has been withdrawn from sale for commercial reasons.
Cat.No. 2134 - Salvinorin A | C23H28O8 | CAS No. 83729-01-5
Description: Highly potent and selective κ agonist
Alternative Names: Divinorin A
Chemical Name: (2S,4aR,6aR,7R,9S,10aS,10bR)-9-(Acetyloxy)-2-(3-furanyl)dodecahydro-6a,10b-dimethyl-4,10-dioxo-2H-naphtho[2,1-c]pyran-7-carboxylic acid methyl ester
Purity: ≥98% (HPLC)
Citations (3)
Literature (5)

Biological Activity for Salvinorin A

Salvinorin A is a potent naturally occuring non-nitrogenous κ-opioid selective agonist that displays high affinity at both native (Ki = 4.3 nM) and cloned (Ki = 16 nM) κ-opioid receptors. Also exhibits allosteric modulation of μ-opioid receptor binding. Reported to be brain-penetrant and displays psychoactive properties..

External Portal Information for Salvinorin A is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of Salvinorin A is reviewed on the chemical probes website.

Technical Data for Salvinorin A

M. Wt 432.47
Formula C23H28O8
Storage Desiccate at -20°C
Purity ≥98% (HPLC)
CAS Number 83729-01-5
PubChem ID 128563
Smiles O=C3[C@]2([H])CC[C@@]([C@]([H])1[C@](C)2C[C@@H]([C@]4=COC=C4)O3)(C)[C@H]([C@@](OC)=O)C[C@H](OC(C)=O)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Salvinorin A

Certificate of Analysis / Product Datasheet
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References for Salvinorin A

References are publications that support the biological activity of the product.

Rothman et al (2007) Salvinorin A: allosteric interactions at the μ-opioid receptor. J.Pharmacol.Exp.Ther. 320 801 PMID: 17060492

Roth et al (2002) Salvinorin A: a potent naturally occuring nonnitrogenous κ opioid selective agonist. Proc.Natl.Acad.Sci.USA 99 11934

Scheffler and Roth (2003) Salvinorin A: the 'magic mint' hallucinogen finds a molecular target in the kappa opioid receptor. TiPS. 24 107

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Keywords: Salvinorin A, Salvinorin A supplier, potent, selective, κ-opioid, kappa-opioid, agonists, KOP, Receptors, OP2, SalvinorinA, DivinorinA, Divinorin, A, Kappa, Opioid, 2134, Tocris Bioscience

3 Citations for Salvinorin A

Citations are publications that use Tocris products. Selected citations for Salvinorin A include:

Mundra et al (2012) Naltrindole inhibits human multiple myeloma cell proliferation in vitro and in a murine xenograft model in vivo. J Pharmacol Exp Ther 342 273 PMID: 22537770

Coffeen et al (2018) Salvinorin A reduces neuropathic nociception in the insular cortex of the rat. Eur.J.Pain. 22 311 PMID: 28975684

Braida et al (2009) Potential anxiolytic- and antidepressant-like effects of salvinorin A, the main active ingredient of Salvia divinorum, in rodents. Br J Pharmacol 157 844 PMID: 19422370

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