Sacubitril calcium

Pricing Availability Delivery Time Qty
Cat.No. 5772 - Sacubitril calcium | C24H28NO5.½Ca | CAS No. 1369773-39-6
Description: Membrane metallo-endopeptidase (neprilysin) inhibitor prodrug; orally bioavailable
Alternative Names: AHU 377
Chemical Name: Ethyl (αR,γS)-γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl-[1,1'-biphenyl]-4-pentanoate hemicalcium salt
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Membrane metallo-endopeptidase (neprilysin) inhibitor prodrug. Increases ANF-induced natriuresis without affecting diuresis in rats. Orally bioavailable.

Technical Data

M. Wt 430.52
Formula C24H28NO5.½Ca
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1369773-39-6
PubChem ID 91827885
InChI Key DDLCKLBRBPYKQS-OXXXZDCLSA-L
Smiles [Ca++].C[C@@H](C(OCC)=O)C[C@H](NC(CCC([O-])=O)=O)CC1=CC=C(C2=CC=CC=C2)C=C1.C[C@@H](C(OCC)=O)C[C@H](NC(CCC([O-])=O)=O)CC1=CC=C(C2=CC=CC=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 43.05 100
ethanol 8.61 20

Preparing Stock Solutions

The following data is based on the product molecular weight 430.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.32 mL 11.61 mL 23.23 mL
5 mM 0.46 mL 2.32 mL 4.65 mL
10 mM 0.23 mL 1.16 mL 2.32 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Ksander et al (1995) Dicarboxylic acid dipeptide neutral endopeptidase inhibitors. J.Med.Chem. 38 1689 PMID: 7752193


If you know of a relevant reference for Sacubitril calcium, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Other Protease Inhibitors

Keywords: Sacubitril calcium, supplier, AHU377, NEP, neprilysin, neutral, MME, membrane, metallo-endopeptidase, inhibitors, inhibits, prodrug, orally, bioavailable, natriuretic, natriuresis, ANF, AHU, 377, Other, Proteases, Other, Proteases, Tocris Bioscience

Citations for Sacubitril calcium

Citations are publications that use Tocris products.

Currently there are no citations for Sacubitril calcium. Do you know of a great paper that uses Sacubitril calcium from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

New Product Guide

New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Apoptosis
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells

Pathways for Sacubitril calcium

Protocols

TODO: Add Protocols