Sacubitril calcium

Pricing Availability   Qty
Cat.No. 5772 - Sacubitril calcium | C24H28NO5.½Ca | CAS No. 1369773-39-6
Description: Membrane metallo-endopeptidase (neprilysin) inhibitor prodrug; orally bioavailable
Alternative Names: AHU 377
Chemical Name: Ethyl (αR,γS)-γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl-[1,1'-biphenyl]-4-pentanoate hemicalcium salt
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Membrane metallo-endopeptidase (neprilysin) inhibitor prodrug. Increases ANF-induced natriuresis without affecting diuresis in rats. Orally bioavailable.

Technical Data

M. Wt 430.52
Formula C24H28NO5.½Ca
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1369773-39-6
PubChem ID 91827885
InChI Key DDLCKLBRBPYKQS-OXXXZDCLSA-L
Smiles [Ca++].C[C@@H](C(OCC)=O)C[C@H](NC(CCC([O-])=O)=O)CC1=CC=C(C2=CC=CC=C2)C=C1.C[C@@H](C(OCC)=O)C[C@H](NC(CCC([O-])=O)=O)CC1=CC=C(C2=CC=CC=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 43.05 100
ethanol 8.61 20

Preparing Stock Solutions

The following data is based on the product molecular weight 430.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.32 mL 11.61 mL 23.23 mL
5 mM 0.46 mL 2.32 mL 4.65 mL
10 mM 0.23 mL 1.16 mL 2.32 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References

References are publications that support the biological activity of the product.

Ksander et al (1995) Dicarboxylic acid dipeptide neutral endopeptidase inhibitors. J.Med.Chem. 38 1689 PMID: 7752193


If you know of a relevant reference for Sacubitril calcium, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Other Protease Inhibitors

Keywords: Sacubitril calcium, Sacubitril calcium supplier, AHU377, NEP, neprilysin, neutral, MME, membrane, metallo-endopeptidase, inhibitors, inhibits, prodrug, orally, bioavailable, natriuretic, natriuresis, ANF, AHU, 377, Other, Proteases, 5772, Tocris Bioscience

Citations for Sacubitril calcium

Citations are publications that use Tocris products.

Currently there are no citations for Sacubitril calcium. Do you know of a great paper that uses Sacubitril calcium from Tocris? Please let us know.

Reviews for Sacubitril calcium

There are currently no reviews for this product. Be the first to review Sacubitril calcium and earn rewards!

Have you used Sacubitril calcium?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


New Product Guide

New Product Guide (Spring/Summer 2018)

Our new product guide highlights over 200 new products added to the Tocris Bioscience range during the second half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Aptamers
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells