Sacubitril calcium

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Cat.No. 5772 - Sacubitril calcium | C24H28NO5.½Ca | CAS No. 1369773-39-6
Description: Membrane metallo-endopeptidase (neprilysin) inhibitor prodrug; orally bioavailable
Alternative Names: AHU 377
Chemical Name: Ethyl (αR,γS)-γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl-[1,1'-biphenyl]-4-pentanoate hemicalcium salt
Purity: ≥98% (HPLC)
Datasheet
Citations
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Biological Activity for Sacubitril calcium

Sacubitril calcium is a membrane metallo-endopeptidase (neprilysin) inhibitor prodrug. Increases ANF-induced natriuresis without affecting diuresis in rats. Orally bioavailable.

Compound Libraries for Sacubitril calcium

Sacubitril calcium is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Sacubitril calcium

M. Wt 430.52
Formula C24H28NO5.½Ca
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1369773-39-6
PubChem ID 91827885
InChI Key DDLCKLBRBPYKQS-OXXXZDCLSA-L
Smiles [Ca++].C[C@@H](C(OCC)=O)C[C@H](NC(CCC([O-])=O)=O)CC1=CC=C(C2=CC=CC=C2)C=C1.C[C@@H](C(OCC)=O)C[C@H](NC(CCC([O-])=O)=O)CC1=CC=C(C2=CC=CC=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Sacubitril calcium

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 43.05 100
ethanol 8.61 20

Preparing Stock Solutions for Sacubitril calcium

The following data is based on the product molecular weight 430.52. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.32 mL 11.61 mL 23.23 mL
5 mM 0.46 mL 2.32 mL 4.65 mL
10 mM 0.23 mL 1.16 mL 2.32 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets for Sacubitril calcium

References for Sacubitril calcium

References are publications that support the biological activity of the product.

Ksander et al (1995) Dicarboxylic acid dipeptide neutral endopeptidase inhibitors. J.Med.Chem. 38 1689 PMID: 7752193


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Citations for Sacubitril calcium

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