Competitive antagonist at group I mGlu1a/1a receptors, mixed effect at mGlu5a/5b receptors; agonist at group II metabotropic glutamate receptors.Racemate also available.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 211.17. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.74 mL||23.68 mL||47.36 mL|
|5 mM||0.95 mL||4.74 mL||9.47 mL|
|10 mM||0.47 mL||2.37 mL||4.74 mL|
|50 mM||0.09 mL||0.47 mL||0.95 mL|
References are publications that support the products' biological activity.
Birse et al (1993) Phenylglycine derivatives as new pharmacological tools for investigating the role of metabotropic glutamate receptors in the central nervous system Neuroscience 52 481 PMID: 7680790
Hayashi et al (1994) Analysis of agonist and antagonist activities of phenylglycine derivatives for different cloned metabotropic glutamate receptor sub-types. J.Neurosci. 14 3370 PMID: 8182479
Kingston et al (1995) Pharmacological analysis of 4-carboxyphenylglycine derivatives: comparison of effects mGluR1α and mGluR5a subtypes. Neuropharmacology 34 887 PMID: 8532170
Sekiyama et al (1996) Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes. Br.J.Pharmacol. 117 1493 PMID: 8730745
If you know of a relevant reference for (S)-4-Carboxy-3-hydroxyphenylglycine, please let us know.
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Keywords: (S)-4-Carboxy-3-hydroxyphenylglycine, supplier, competitive, Group, I, antagonists, group, II, agonists, mGlur, Receptors, mGlu1, mGlu5, mGluR1, mGluR5, Glutamate, Metabotropic, mGlu2, mGlu3, mGluR2, mGluR3, (S)-4C3HPG, Glutamate, (Metabotropic), Group, I, Receptors, Glutamate, (Metabotropic), Group, II, Receptors, Glutamate, (Metabotropic), Group, I, Receptors, Tocris Bioscience
1 Citation for (S)-4-Carboxy-3-hydroxyphenylglycine
Citations are publications that use Tocris products. Selected citations for (S)-4-Carboxy-3-hydroxyphenylglycine include:
Lee and Flavell (2014) Inhibition and enhancement of contextual fear memory destabilization. Front Behav Neurosci 8 144 PMID: 24808841
Do you know of a great paper that uses (S)-4-Carboxy-3-hydroxyphenylglycine from Tocris? If so please let us know.
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