(S)-4-Carboxy-3-hydroxyphenylglycine

Discontinued Product

(S)-4-Carboxy-3-hydroxyphenylglycine (Cat. No. 0320) has been withdrawn from sale for commercial reasons.
Description: Group I mGlu antagonist; also group II mGlu agonist
Alternative Names: (S)-4C3HPG
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (5)

Biological Activity for (S)-4-Carboxy-3-hydroxyphenylglycine

(S)-4-Carboxy-3-hydroxyphenylglycine is a competitive antagonist at group I mGlu1a/1a receptors, mixed effect at mGlu5a/5b receptors; agonist at group II metabotropic glutamate receptors.

Racemate also available.

Technical Data for (S)-4-Carboxy-3-hydroxyphenylglycine

M. Wt 211.17
Formula C9H9NO5
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 85148-82-9
PubChem ID 5311455
InChI Key GXZSAQLJWLCLOX-ZETCQYMHSA-N
Smiles OC1=C(C(O)=O)C=CC([C@]([H])(N)C(O)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for (S)-4-Carboxy-3-hydroxyphenylglycine

Certificate of Analysis / Product Datasheet
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References for (S)-4-Carboxy-3-hydroxyphenylglycine

References are publications that support the biological activity of the product.

Birse et al (1993) Phenylglycine derivatives as new pharmacological tools for investigating the role of metabotropic glutamate receptors in the central nervous system Neuroscience 52 481 PMID: 7680790

Hayashi et al (1994) Analysis of agonist and antagonist activities of phenylglycine derivatives for different cloned metabotropic glutamate receptor sub-types. J.Neurosci. 14 3370 PMID: 8182479

Kingston et al (1995) Pharmacological analysis of 4-carboxyphenylglycine derivatives: comparison of effects mGluR1α and mGluR5a subtypes. Neuropharmacology 34 887 PMID: 8532170

Sekiyama et al (1996) Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes. Br.J.Pharmacol. 117 1493 PMID: 8730745

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Keywords: (S)-4-Carboxy-3-hydroxyphenylglycine, (S)-4-Carboxy-3-hydroxyphenylglycine supplier, competitive, Group, I, antagonists, group, II, agonists, mGlur, Receptors, mGlu1, mGlu5, mGluR1, mGluR5, Glutamate, Metabotropic, mGlu2, mGlu3, mGluR2, mGluR3, (S)-4C3HPG, (Metabotropic), 0320, Tocris Bioscience

1 Citation for (S)-4-Carboxy-3-hydroxyphenylglycine

Citations are publications that use Tocris products. Selected citations for (S)-4-Carboxy-3-hydroxyphenylglycine include:

Lee and Flavell (2014) Inhibition and enhancement of contextual fear memory destabilization. Front Behav Neurosci 8 144 PMID: 24808841


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Metabotropic Glutamate Receptors Scientific Review

Metabotropic Glutamate Receptors Scientific Review

Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.

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Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

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Huntington's disease (HD) is a severe monogenic neurodegenerative disorder, which is characterized by the prevalent loss of GABAergic medium spiny neurons (MSN) in the striatum. This poster summarizes the effects of mutant huntingtin aggregation implicated in the pathology of HD, as well as highlighting the use of iPSCs for HD modeling.

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Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.