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Submit ReviewRuBi GABA trimethylphosphine
Description: Caged GABA; inhibits neural activity
Alternative Names: RuBi-GABA-PMe3
Chemical Name: (bis(2,2'-Bipyridine-N,N')trimethylphosphine)-4-aminobutyric acid ruthenium complex sodium hexafluorophosphate salt
Biological Activity for RuBi GABA trimethylphosphine
RuBi GABA trimethylphosphine is a modified version of RuBi-GABA (Cat. No. 3400). Suppresses cortical local field potential (LFP) activity in anesthetized mice after activation with a blue laser pulse (473 nm); inhibits neural activity.
Licensing Information
Sold under licence from Columbia University
Technical Data for RuBi GABA trimethylphosphine
| M. Wt | 904.56 |
| Formula | C27H33N5O2PRu.PF6.NaPF6 |
| Storage | Store at -20°C |
| InChI Key | AYYRUPXLUXSCBC-UHFFFAOYSA-N |
| Smiles | [F-][P+5]([F-])([F-])([F-])([F-])[F-].[F-][P+5]([F-])([F-])([F-])([F-])[F-].CP(C)([Ru+2]12([N]3=CC=CC=C3C4=CC=CC=[N]14)([N]5=CC=CC=C5C6=CC=CC=[N]26)NCCCC([O-])=O)C.[Na+] |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for RuBi GABA trimethylphosphine
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 45.23 | 50 |
Preparing Stock Solutions for RuBi GABA trimethylphosphine
The following data is based on the product molecular weight 904.56. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 2.21 mL | 11.06 mL | 22.11 mL |
| 2.5 mM | 0.44 mL | 2.21 mL | 4.42 mL |
| 5 mM | 0.22 mL | 1.11 mL | 2.21 mL |
| 25 mM | 0.04 mL | 0.22 mL | 0.44 mL |
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Product Datasheets for RuBi GABA trimethylphosphine
References for RuBi GABA trimethylphosphine
References are publications that support the biological activity of the product.
Lopes-dos-Santos et al (2011) In vivo photorelease of GABA in the mouse cortex. Braz.J.Med.Biol.Res. 44 688 PMID: 21755263
Filevich et al (2013) RuBiGABA-2: a hydrophilic caged GABA with long wavelength sensitivity. Photochem.Photobiol.Sci. 12 1565 PMID: 23674097
If you know of a relevant reference for RuBi GABA trimethylphosphine, please let us know.
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Citations for RuBi GABA trimethylphosphine
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
GABA Receptors Scientific Review
Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.
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The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.