RU-SKI 43 hydrochloride

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Cat.No. 4886 - RU-SKI 43 hydrochloride | C22H30N2O2S.HCl
Description: Hedgehog acyltransferase (Hhat) inhibitor; cell permeable
Chemical Name: 2-((2-Methylbutyl)amino)-1-(4-((3-methylphenoxy)methyl-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)ethanone hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Hedgehog acyltransferase (Hhat) inhibitor (IC50 = 850 nM). Inhibits Sonic Hedgehog N (ShhN) palmitoylation in vitro. Has no effect on porcupine-induced fatty acid acylation of Wnt39a. Attenuates pancreatic cancer cell proliferation. Cell permeable.

Compound Libraries

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Technical Data

M. Wt 423.01
Formula C22H30N2O2S.HCl
Storage Store at +4°C
Purity ≥98% (HPLC)
PubChem ID 90488982
InChI Key JBBKLHJLHRGJSQ-UHFFFAOYSA-N
Smiles O=C(CNCC(CC)C)N1CCC3=C(C=CS3)C1COC2=CC(C)=CC=C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 42.3 100

Preparing Stock Solutions

The following data is based on the product molecular weight 423.01. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.36 mL 11.82 mL 23.64 mL
5 mM 0.47 mL 2.36 mL 4.73 mL
10 mM 0.24 mL 1.18 mL 2.36 mL
50 mM 0.05 mL 0.24 mL 0.47 mL

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References

References are publications that support the biological activity of the product.

Petrova et al (2013) Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling. Nat.Chem.Biol. 9 247 PMID: 23416332

Petrova et al (2014) Hedgehog acyltransferase as a target in pancreatic ductal adenocarcinoma. Oncogene 34 263 PMID: 24469057


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Keywords: RU-SKI 43 hydrochloride, RU-SKI 43 hydrochloride supplier, RU-SKI43, Hydrochloride, Hedgehog, acyltransferase, inhibitors, inhibits, Hh, sonic, ShhN, Hhat, palmitoylation, Signaling, 4886, Tocris Bioscience

Citations for RU-SKI 43 hydrochloride

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