RU-SKI 43 hydrochloride

Discontinued Product

RU-SKI 43 hydrochloride (Cat. No. 4886) has been withdrawn from sale for commercial reasons.
Description: Hedgehog acyltransferase (Hhat) inhibitor; cell permeable
Chemical Name: 2-((2-Methylbutyl)amino)-1-(4-((3-methylphenoxy)methyl-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)ethanone hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (4)

Biological Activity for RU-SKI 43 hydrochloride

RU-SKI 43 hydrochloride is a hedgehog acyltransferase (Hhat) inhibitor (IC50 = 850 nM). Inhibits Sonic Hedgehog N (ShhN) palmitoylation in vitro. Has no effect on porcupine-induced fatty acid acylation of Wnt39a. Attenuates pancreatic cancer cell proliferation. Cell permeable.

Technical Data for RU-SKI 43 hydrochloride

M. Wt 423.01
Formula C22H30N2O2S.HCl
Storage Store at +4°C
Purity ≥98% (HPLC)
PubChem ID 90488982
InChI Key JBBKLHJLHRGJSQ-UHFFFAOYSA-N
Smiles O=C(CNCC(CC)C)N1CCC3=C(C=CS3)C1COC2=CC(C)=CC=C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for RU-SKI 43 hydrochloride

References for RU-SKI 43 hydrochloride

References are publications that support the biological activity of the product.

Petrova et al (2013) Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling. Nat.Chem.Biol. 9 247 PMID: 23416332

Petrova et al (2014) Hedgehog acyltransferase as a target in pancreatic ductal adenocarcinoma. Oncogene 34 263 PMID: 24469057

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Keywords: RU-SKI 43 hydrochloride, RU-SKI 43 hydrochloride supplier, RU-SKI43, Hydrochloride, Hedgehog, acyltransferase, inhibitors, inhibits, Hh, sonic, ShhN, Hhat, palmitoylation, Signaling, 4886, Tocris Bioscience

Citations for RU-SKI 43 hydrochloride

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Currently there are no citations for RU-SKI 43 hydrochloride.

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