RU-SKI 43 hydrochloride
Hedgehog acyltransferase (Hhat) inhibitor (IC50 = 850 nM). Inhibits Sonic Hedgehog N (ShhN) palmitoylation in vitro. Has no effect on porcupine-induced fatty acid acylation of Wnt39a. Attenuates pancreatic cancer cell proliferation. Cell permeable.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 423.01. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.36 mL||11.82 mL||23.64 mL|
|5 mM||0.47 mL||2.36 mL||4.73 mL|
|10 mM||0.24 mL||1.18 mL||2.36 mL|
|50 mM||0.05 mL||0.24 mL||0.47 mL|
References are publications that support the products' biological activity.
Petrova et al (2013) Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling. Nat.Chem.Biol. 9 247 PMID: 23416332
Petrova et al (2014) Hedgehog acyltransferase as a target in pancreatic ductal adenocarcinoma. Oncogene 34 263 PMID: 24469057
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Literature in this Area
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Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.