(RS)-APICA

Discontinued Product

(RS)-APICA (Cat. No. 1073) has been withdrawn from sale for commercial reasons.
Description: Selective group II mGlu antagonist
Chemical Name: (RS)-1-Amino-5-phosphonoindan-1-carboxylic acid
Datasheet
Citations (2)
Reviews
Literature (4)

Biological Activity for (RS)-APICA

(RS)-APICA is a rigidified analog of MPPG (Cat. No. 0853); selective group II metabotropic glutamate receptor antagonist (IC50 = 30 μM) with no significant effect on group I and III mGlu receptors at concentrations up to 1 mM. Increases extracellular glutamate concentrations and possesses unusual inverse agonist-like action.

Technical Data for (RS)-APICA

M. Wt 257.18
Formula C10H12NO5P
Storage Desiccate at +4°C
CAS Number 170847-18-4
PubChem ID 4694355
InChI Key ZNQZXIHSJUDIKL-UHFFFAOYSA-N
Smiles NC2(C(O)=O)CCC1=CC(P(O)(O)=O)=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for (RS)-APICA

Certificate of Analysis / Product Datasheet
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References for (RS)-APICA

References are publications that support the biological activity of the product.

Krenz et al (2000) Group I, II and III mGluR compounds affect rhythm generation in the gastric circuit of the crustacean stomatogastric ganglion. J.Neurophysiol. 83 1188 PMID: 10712449

Xi et al (2002) Group II metabotropic glutamate receptors modulate extracellular glutamate in the nucleus accumbens. J.Pharmacol.Exp.Ther. 300 162 PMID: 11752112

Ma et al (1997) Synthesis and biological activity of cyclic analogues of MPPG and MCPG as metabotropic glutamate receptor antagonists. Bioorg.Med.Chem.Lett. 7 1195

View Related Products by Product Action

View all Glutamate (Metabotropic) Group II Receptor Antagonists

Keywords: (RS)-APICA, (RS)-APICA supplier, Selective, group, II, antagonists, mGlur, Group, Receptors, mGlu2, mGlu3, mGluR2, mGluR3, Glutamate, Metabotropic, (Metabotropic), 1073, Tocris Bioscience

2 Citations for (RS)-APICA

Citations are publications that use Tocris products. Selected citations for (RS)-APICA include:

Scholler (2017) HTS-compatible FRET-based conformational sensors clarify membrane receptor activation. Nat Chem Biol 13 372 PMID: 28135236

Jiang et al (2006) Activation of group III metabotropic glutamate receptors attenuates rotenone toxicity on DArgic neurons through a microtubule-dependent mechanism. J Neurosci 26 4318 PMID: 16624952


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Metabotropic Glutamate Receptors Scientific Review

Metabotropic Glutamate Receptors Scientific Review

Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.

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Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

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Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.