(RS)-APICA

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Cat.No. 1073 - (RS)-APICA | C10H12NO5P | CAS No. 170847-18-4
Description: Selective group II mGlu antagonist
Chemical Name: (RS)-1-Amino-5-phosphonoindan-1-carboxylic acid
Datasheet
Citations (2)
Reviews
Literature

Biological Activity

Rigidified analog of MPPG (Cat. No. 0853); selective group II metabotropic glutamate receptor antagonist (IC50 = 30 μM) with no significant effect on group I and III mGlu receptors at concentrations up to 1 mM. Increases extracellular glutamate concentrations and possesses unusual inverse agonist-like action.

Technical Data

M. Wt 257.18
Formula C10H12NO5P
Storage Desiccate at +4°C
CAS Number 170847-18-4
PubChem ID 4694355
InChI Key ZNQZXIHSJUDIKL-UHFFFAOYSA-N
Smiles NC2(C(O)=O)CCC1=CC(P(O)(O)=O)=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 100 mM in 1.1eq. NaOH

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Krenz et al (2000) Group I, II and III mGluR compounds affect rhythm generation in the gastric circuit of the crustacean stomatogastric ganglion. J.Neurophysiol. 83 1188 PMID: 10712449

Xi et al (2002) Group II metabotropic glutamate receptors modulate extracellular glutamate in the nucleus accumbens. J.Pharmacol.Exp.Ther. 300 162 PMID: 11752112

Ma et al (1997) Synthesis and biological activity of cyclic analogues of MPPG and MCPG as metabotropic glutamate receptor antagonists. Bioorg.Med.Chem.Lett. 7 1195


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View all Glutamate (Metabotropic) Group II Receptor Antagonists

Keywords: (RS)-APICA, (RS)-APICA supplier, Selective, group, II, antagonists, mGlur, Group, Receptors, mGlu2, mGlu3, mGluR2, mGluR3, Glutamate, Metabotropic, (Metabotropic), 1073, Tocris Bioscience

2 Citations for (RS)-APICA

Citations are publications that use Tocris products. Selected citations for (RS)-APICA include:

Scholler (2017) HTS-compatible FRET-based conformational sensors clarify membrane receptor activation. Nat Chem Biol 13 372 PMID: 28135236

Jiang et al (2006) Activation of group III metabotropic glutamate receptors attenuates rotenone toxicity on DArgic neurons through a microtubule-dependent mechanism. J Neurosci 26 4318 PMID: 16624952


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