Ro 19-4603

Discontinued Product

Ro 19-4603 (Cat. No. 1995) has been withdrawn from sale for commercial reasons.
Description: Benzodiazepine inverse agonist
Chemical Name: 5,6-Dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a]thieno[2,3-f][1,4]diazepine-3-carboxylic acid 1,1-dimethylethyl ester
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature (2)

Biological Activity for Ro 19-4603

Benzodiazepine inverse agonist. Binds with high affinity to both diazepam-sensitive (DS) and diazepam-insensitive (DI) GABAA receptors (Ki values are ~ 0.2 and ~ 2.6 nM for DS and DI receptors respectively). Antagonizes effects of ethanol on locomotor behavior and suppresses ethanol intake in alcohol-preferring rats.

Technical Data for Ro 19-4603

M. Wt 319.38
Formula C15H17N3O3S
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 99632-94-7
PubChem ID 127382
InChI Key ZIGMMUKDYCABPW-UHFFFAOYSA-N
Smiles CN1CC2=C(N=CN2C2=C(SC=C2)C1=O)C(=O)OC(C)(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for Ro 19-4603

References are publications that support the biological activity of the product.

Wong and Skolnick (1992) High affinity ligands for 'D.pam-insensitive' benzodiazepine receptors. Eur.J.Pharmacol. 225 63 PMID: 1311690

June et al (1995) Effects of the benzodiazepine inverse agonist RO19-4603 on the maintenance of tolerance to a single dose of ethanol. J.Pharmacol.Exp.Ther. 274 1105 PMID: 7562476

June et al (1998) The novel benzodiazepine inverse agonist RO19-4603 antagonises ethanol motivated behaviours: neuropharmacological studies. Brain Res. 784 256 PMID: 9518641

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Keywords: Ro 19-4603, Ro 19-4603 supplier, Benzodiazepine, inverse, agonists, GABAA, Receptors, Ro19-4603, 1995, Tocris Bioscience

Citations for Ro 19-4603

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Currently there are no citations for Ro 19-4603.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


GABA Receptors Scientific Review

GABA Receptors Scientific Review

Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.

Addiction Poster

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.