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Biological Activity for Ro 15-4513
Ro 15-4513 is a high affinity benzodiazepine ligand. Ki values are 3.1 and 5.3 nM for diazepam-insensitive (DI) and diazepam-sensitive (DS) benzodiazepine receptors respectively. Acts as partial inverse agonist at recombinant DS α1-, α2-, α3- and α5-GABAA receptors. Displays partial agonism at DI α4- and α6-GABAA receptors. Antagonizes several behavioral and neurochemical effects of ethanol. Proconvulsant and anxiogenic.
Technical Data for Ro 15-4513
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Ro 15-4513
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Ro 15-4513
The following data is based on the product molecular weight 326.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||30.65 mL||153.23 mL||306.46 mL|
|0.5 mM||6.13 mL||30.65 mL||61.29 mL|
|1 mM||3.06 mL||15.32 mL||30.65 mL|
|5 mM||0.61 mL||3.06 mL||6.13 mL|
References for Ro 15-4513
References are publications that support the biological activity of the product.
Suzdak et al (1986) A selective imidazobenzodiazepine antagonist of ethanol in the rat. Science 234 1243 PMID: 3022383
Wong and Skolnick (1992) High affinity ligands for 'D.pam-insensitive' benzodiazepine receptors. Eur.J.Pharmacol. 225 63 PMID: 1311690
Knoflach et al (1996) Pharmacological modulation of the D.pam-insensitive recombinant gamma-aminobutyric acidA receptors alpha 4 beta 2 gamma 2 and alpha 6 beta 2 gamma 2. Mol.Pharmacol. 50 1253 PMID: 8913357
If you know of a relevant reference for Ro 15-4513, please let us know.
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Keywords: Ro 15-4513, Ro 15-4513 supplier, Benzodiazepine, partial, inverse, agonists, GABAA, Receptors, Ro15-4513, 1997, Tocris Bioscience
2 Citations for Ro 15-4513
Citations are publications that use Tocris products. Selected citations for Ro 15-4513 include:
Koh et al (2013) Selective GABA(A) α5 positive allosteric modulators improve cognitive function in aged rats with memory impairment. J Neurosci 64 145 PMID: 22732440
Tracy et al (2016) Negative allosteric modulation of GABAA receptors inhibits facilitation of brain stimulation reward by drugs of abuse in C57BL6/J mice. Psychopharmacology 233 715 PMID: 26612620
Do you know of a great paper that uses Ro 15-4513 from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
GABA Receptors Scientific Review
Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.
Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.