Ro 15-4513

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Description: Benzodiazepine partial inverse agonist
Chemical Name: 8-Azido-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid ethyl ester
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews
Literature (2)

Biological Activity for Ro 15-4513

Ro 15-4513 is a high affinity benzodiazepine ligand. Ki values are 3.1 and 5.3 nM for diazepam-insensitive (DI) and diazepam-sensitive (DS) benzodiazepine receptors respectively. Acts as partial inverse agonist at recombinant DS α1-, α2-, α3- and α5-GABAA receptors. Displays partial agonism at DI α4- and α6-GABAA receptors. Antagonizes several behavioral and neurochemical effects of ethanol. Proconvulsant and anxiogenic.

Technical Data for Ro 15-4513

M. Wt 326.31
Formula C15H14N6O3
Storage Desiccate at +4°C
Purity ≥98% (HPLC)
CAS Number 91917-65-6
PubChem ID 5081
InChI Key CFSOJZTUTOQNIA-UHFFFAOYSA-N
Smiles CCOC(=O)C1=C2CN(C)C(=O)C3=C(C=CC(=C3)N=[N+]=[N-])N2C=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Ro 15-4513

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 1.63 5
DMSO 3.26 10

Preparing Stock Solutions for Ro 15-4513

The following data is based on the product molecular weight 326.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 30.65 mL 153.23 mL 306.46 mL
0.5 mM 6.13 mL 30.65 mL 61.29 mL
1 mM 3.06 mL 15.32 mL 30.65 mL
5 mM 0.61 mL 3.06 mL 6.13 mL

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Product Datasheets for Ro 15-4513

Certificate of Analysis / Product Datasheet
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References for Ro 15-4513

References are publications that support the biological activity of the product.

Suzdak et al (1986) A selective imidazobenzodiazepine antagonist of ethanol in the rat. Science 234 1243 PMID: 3022383

Wong and Skolnick (1992) High affinity ligands for 'D.pam-insensitive' benzodiazepine receptors. Eur.J.Pharmacol. 225 63 PMID: 1311690

Knoflach et al (1996) Pharmacological modulation of the D.pam-insensitive recombinant gamma-aminobutyric acidA receptors alpha 4 beta 2 gamma 2 and alpha 6 beta 2 gamma 2. Mol.Pharmacol. 50 1253 PMID: 8913357


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Keywords: Ro 15-4513, Ro 15-4513 supplier, Benzodiazepine, partial, inverse, agonists, GABAA, Receptors, Ro15-4513, 1997, Tocris Bioscience

2 Citations for Ro 15-4513

Citations are publications that use Tocris products. Selected citations for Ro 15-4513 include:

Tracy et al (2016) Negative allosteric modulation of GABAA receptors inhibits facilitation of brain stimulation reward by drugs of abuse in C57BL6/J mice. Psychopharmacology 233 715 PMID: 26612620

Koh et al (2013) Selective GABA(A) α5 positive allosteric modulators improve cognitive function in aged rats with memory impairment. J Neurosci 64 145 PMID: 22732440


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


GABA Receptors Scientific Review

GABA Receptors Scientific Review

Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.

Addiction Poster

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.