Ro 15-4513

Pricing Availability Delivery Time Qty
Cat.No. 1997 - Ro 15-4513 | C15H14N6O3 | CAS No. 91917-65-6
Description: Benzodiazepine partial inverse agonist
Chemical Name: 8-Azido-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid ethyl ester
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews
Literature

Biological Activity

High affinity benzodiazepine ligand. Ki values are 3.1 and 5.3 nM for diazepam-insensitive (DI) and diazepam-sensitive (DS) benzodiazepine receptors respectively. Acts as partial inverse agonist at recombinant DS α1-, α2-, α3- and α5-GABAA receptors. Displays partial agonism at DI α4- and α6-GABAA receptors. Antagonizes several behavioral and neurochemical effects of ethanol. Proconvulsant and anxiogenic.

Technical Data

M. Wt 326.31
Formula C15H14N6O3
Storage Desiccate at +4°C
Purity ≥98% (HPLC)
CAS Number 91917-65-6
PubChem ID 5081
InChI Key CFSOJZTUTOQNIA-UHFFFAOYSA-N
Smiles CCOC(=O)C1=C2CN(C)C(=O)C3=C(C=CC(=C3)N=[N+]=[N-])N2C=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 3.26 10
ethanol 1.63 5

Preparing Stock Solutions

The following data is based on the product molecular weight 326.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.06 mL 15.32 mL 30.65 mL
5 mM 0.61 mL 3.06 mL 6.13 mL
10 mM 0.31 mL 1.53 mL 3.06 mL
50 mM 0.06 mL 0.31 mL 0.61 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Suzdak et al (1986) A selective imidazobenzodiazepine antagonist of ethanol in the rat. Science 234 1243 PMID: 3022383

Wong and Skolnick (1992) High affinity ligands for 'diazepam-insensitive' benzodiazepine receptors. Eur.J.Pharmacol. 225 63 PMID: 1311690

Knoflach et al (1996) Pharmacological modulation of the diazepam-insensitive recombinant gamma-aminobutyric acidA receptors alpha 4 beta 2 gamma 2 and alpha 6 beta 2 gamma 2. Mol.Pharmacol. 50 1253 PMID: 8913357


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Keywords: Ro 15-4513, supplier, Benzodiazepine, partial, inverse, agonists, GABAA, Receptors, Ro15-4513, GABAA, Receptors, GABAA, Receptors, Tocris Bioscience

2 Citations for Ro 15-4513

Citations are publications that use Tocris products. Selected citations for Ro 15-4513 include:

Tracy et al (2016) Negative allosteric modulation of GABAA receptors inhibits facilitation of brain stimulation reward by drugs of abuse in C57BL6/J mice. Psychopharmacology 233 715 PMID: 26612620

Koh et al (2013) Selective GABA(A) α5 positive allosteric modulators improve cognitive function in aged rats with memory impairment. J Neurosci 64 145 PMID: 22732440


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