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Inhibitor of NF-κB activation, possibly via selective inhibition of LPS- and TNF-α-induced IκBα ubiquitination (IC50 = 3 μM). Blocks subsequent production of TNF-α, IL-1β and IL-6. Inhibits mucin production in an in vitro model of COPD, and is anti-inflammatory following oral administration in vivo. Also weakly inhibits EGFR, 5-lipoxygenase and iNOS.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 245.26. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.08 mL||20.39 mL||40.77 mL|
|5 mM||0.82 mL||4.08 mL||8.15 mL|
|10 mM||0.41 mL||2.04 mL||4.08 mL|
|50 mM||0.08 mL||0.41 mL||0.82 mL|
References are publications that support the biological activity of the product.
Conalty et al (1976) Anticancer agents. XII. Pyridazine and benzodiazine derivatives. Proc.R.Ir.Acad.B. 76 151 PMID: 967871
Swinney et al (2002) A small molecule ubiquitination inhibitor blocks NF-κB-dependent cytokine expression in cells and rats. J.Biol.Chem. 277 23573 PMID: 11950839
Baginski et al (2002) Glucocorticoid modulation of MUC5AC secretion in H292 cells. Am.Soc.Cell Biol.Abstr. 765
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Keywords: Ro 106-9920, Ro 106-9920 supplier, inhibitors, inhibits, NF-κB, NF-kappaB, NF-kB, activation, Transcription, Factors, Nuclear, Factor, Kappa, B, Ro106-9920, NF-kB/IkB, 1778, Tocris Bioscience
4 Citations for Ro 106-9920
Citations are publications that use Tocris products. Selected citations for Ro 106-9920 include:
Siew et al (2019) Galectin-3 is required for the microglia-mediated brain inflammation in a model of Huntington's disease. Nat Commun 10 3473 PMID: 31375685
Lapponi et al (2013) Regulation of neutrophil extracellular trap formation by anti-inflammatory drugs. J Pharmacol Exp Ther 345 430 PMID: 23536315
Huang et al (2015) ATF4 is a novel regulator of MCP-1 in microvascular endothelial cells. J Inflamm (Lond) 12 31 PMID: 25914608
Marinelli et al (2015) Ligand engagement of Toll-like receptors regulates their expression in cortical microglia and astrocytes. PLoS One 12 244 PMID: 26714634
Do you know of a great paper that uses Ro 106-9920 from Tocris? Please let us know.
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