Ro 106-9920

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Cat.No. 1778 - Ro 106-9920 | C10H7N5OS | CAS No. 62645-28-7
Description: Inhibitor of NF-κB activation
Chemical Name: 6-(Phenylsulfinyl)tetrazolo[1,5-b]pyridazine
Purity: ≥99% (HPLC)
Datasheet
Citations (3)
Reviews
Literature
Pathways

Biological Activity

Inhibitor of NF-κB activation, possibly via selective inhibition of LPS- and TNF-α-induced IκBα ubiquitination (IC50 = 3 μM). Blocks subsequent production of TNF-α, IL-1β and IL-6. Inhibits mucin production in an in vitro model of COPD, and is anti-inflammatory following oral administration in vivo. Also weakly inhibits EGFR, 5-lipoxygenase and iNOS.

Compound Libraries

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Technical Data

M. Wt 245.26
Formula C10H7N5OS
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 62645-28-7
PubChem ID 3906779
InChI Key JFSXSNSCPNFCDM-UHFFFAOYSA-N
Smiles O=S(C1=CC=CC=C1)C1=NN2N=NN=C2C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 24.53 100
ethanol 1.23 5

Preparing Stock Solutions

The following data is based on the product molecular weight 245.26. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.08 mL 20.39 mL 40.77 mL
5 mM 0.82 mL 4.08 mL 8.15 mL
10 mM 0.41 mL 2.04 mL 4.08 mL
50 mM 0.08 mL 0.41 mL 0.82 mL

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References

References are publications that support the biological activity of the product.

Conalty et al (1976) Anticancer agents. XII. Pyridazine and benzodiazine derivatives. Proc.R.Ir.Acad.B. 76 151 PMID: 967871

Swinney et al (2002) A small molecule ubiquitination inhibitor blocks NF-κB-dependent cytokine expression in cells and rats. J.Biol.Chem. 277 23573 PMID: 11950839

Baginski et al (2002) Glucocorticoid modulation of MUC5AC secretion in H292 cells. Am.Soc.Cell Biol.Abstr. 765


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View all NF-κB and IκB Inhibitors

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3 Citations for Ro 106-9920

Citations are publications that use Tocris products. Selected citations for Ro 106-9920 include:

Huang et al (2015) ATF4 is a novel regulator of MCP-1 in microvascular endothelial cells. J Inflamm (Lond) 12 31 PMID: 25914608

Marinelli et al (2015) Ligand engagement of Toll-like receptors regulates their expression in cortical microglia and astrocytes. PLoS One 12 244 PMID: 26714634

Lapponi et al (2013) Regulation of neutrophil extracellular trap formation by anti-inflammatory drugs. J Pharmacol Exp Ther 345 430 PMID: 23536315


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Literature in this Area

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Pathways for Ro 106-9920

NF-κB

NF-κB Signaling Pathway

NF-κB signaling plays an important role in inflammation, the innate and adaptive immune response and stress. Dysregulated signaling can occur in inflammatory and autoimmune diseases.