Ro 106-9920

Discontinued Product

Ro 106-9920 (Cat. No. 1778) has been withdrawn from sale for commercial reasons.
Cat.No. 1778 - Ro 106-9920 | C10H7N5OS | CAS No. 62645-28-7
Description: Inhibitor of NF-κB activation
Chemical Name: 6-(Phenylsulfinyl)tetrazolo[1,5-b]pyridazine
Purity: ≥99% (HPLC)
Datasheet
Citations (4)
Reviews
Literature (3)
Pathways (1)

Biological Activity for Ro 106-9920

Ro 106-9920 is an inhibitor of NF-κB activation, possibly via selective inhibition of LPS- and TNF-α-induced IκBα ubiquitination (IC50 = 3 μM). Blocks subsequent production of TNF-α, IL-1β and IL-6. Inhibits mucin production in an in vitro model of COPD, and is anti-inflammatory following oral administration in vivo. Also weakly inhibits EGFR, 5-lipoxygenase and iNOS.

Technical Data for Ro 106-9920

M. Wt 245.26
Formula C10H7N5OS
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 62645-28-7
PubChem ID 3906779
InChI Key JFSXSNSCPNFCDM-UHFFFAOYSA-N
Smiles O=S(C1=CC=CC=C1)C1=NN2N=NN=C2C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for Ro 106-9920

References are publications that support the biological activity of the product.

Conalty et al (1976) Anticancer agents. XII. Pyridazine and benzodiazine derivatives. Proc.R.Ir.Acad.B. 76 151 PMID: 967871

Swinney et al (2002) A small molecule ubiquitination inhibitor blocks NF-κB-dependent cytokine expression in cells and rats. J.Biol.Chem. 277 23573 PMID: 11950839

Baginski et al (2002) Glucocorticoid modulation of MUC5AC secretion in H292 cells. Am.Soc.Cell Biol.Abstr. 765

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Keywords: Ro 106-9920, Ro 106-9920 supplier, inhibitors, inhibits, NF-κB, NF-kappaB, NF-kB, activation, Transcription, Factors, Nuclear, Factor, Kappa, B, Ro106-9920, NF-kB/IkB, 1778, Tocris Bioscience

4 Citations for Ro 106-9920

Citations are publications that use Tocris products. Selected citations for Ro 106-9920 include:

Lapponi et al (2013) Regulation of neutrophil extracellular trap formation by anti-inflammatory drugs. J Pharmacol Exp Ther 345 430 PMID: 23536315

Siew et al (2019) Galectin-3 is required for the microglia-mediated brain inflammation in a model of Huntington's disease. Nat Commun 10 3473 PMID: 31375685

Huang et al (2015) ATF4 is a novel regulator of MCP-1 in microvascular endothelial cells. J Inflamm (Lond) 12 31 PMID: 25914608

Marinelli et al (2015) Ligand engagement of Toll-like receptors regulates their expression in cortical microglia and astrocytes. PLoS One 12 244 PMID: 26714634


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Pathways for Ro 106-9920

NF-κB

NF-κB Signaling Pathway

NF-κB signaling plays an important role in inflammation, the innate and adaptive immune response and stress. Dysregulated signaling can occur in inflammatory and autoimmune diseases.