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Rifaximin

Cat. No. 5359 1 Review Submit a Review Datasheet / COA / SDS
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Description: Pregnane X receptor agonist; antibiotic
Chemical Name: (2S,16Z,18E,20S,21S,22R,23R,24R,25S,26R,27S,28E)-25-(Acetyloxy)-5,6,21,23-tetrahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-2,7-(epoxypentadeca[1,11,13]trienimino)benzofuro[4,5-e]pyrido[1,2-a]benzimidazole-1,15(2H)-dione
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews (1)
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Rifaximin

Rifaximin is a pregnane X receptor (PXR) agonist; antibiotic. Reduces number of colon tumors and suppresses expression of TNFα and Il-1β induced in a colon cancer, PXR-humanized mouse model. Increases apoptosis and decreased proliferation in HT-29 cells. Exhibits low gastrointestinal absorption while retaining its antibacterial activity. Active against gram-positive and gram-negative bacteria.

Compound Libraries for Rifaximin

Rifaximin is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Rifaximin

M. Wt 785.88
Formula C43H51N3O11
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 80621-81-4
PubChem ID 6436173
InChI Key NZCRJKRKKOLAOJ-XRCRFVBUSA-N
Smiles O=C(/C(C)=C\C=C\[C@H](C)[C@H](O)[C@H]([C@H]([C@@H](C)[C@H](OC(C)=O)[C@H](C)[C@@H](OC)/C=C/O[C@@]5(C)O4)O)C)NC2=C(O)C1=C(O)C(C)=C4C(C5=O)=C1C3=C2N6C(C=C(C)C=C6)=N3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Rifaximin

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 78.59 100
ethanol 78.59 100

Preparing Stock Solutions for Rifaximin

The following data is based on the product molecular weight 785.88. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.27 mL 6.36 mL 12.72 mL
5 mM 0.25 mL 1.27 mL 2.54 mL
10 mM 0.13 mL 0.64 mL 1.27 mL
50 mM 0.03 mL 0.13 mL 0.25 mL

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References for Rifaximin

References are publications that support the biological activity of the product.

Cheng et al (2014) Activation of intestinal human pregnane X receptor protects against azoxymethane/dextran sulfate sodium-induced colon cancer. J.Pharmacol.Exp.Ther. 351 559 PMID: 25277138

Jiang et al (2005) Rifaximin: in vitro and in vivo antibacterial activity-a review. Chemotherapy 51 67 PMID: 15855749

Stradi et al (2010) Structural elucidation of the rifa. Ph. Eur. Impurity H. J.Pharm.Biomed.Anal. 51 858 PMID: 19926422

If you know of a relevant reference for Rifaximin, please let us know.

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Keywords: Rifaximin, Rifaximin supplier, Antibiotic, Pregnane, X, receptors, agonists, PXR, colon, tumors, tumours, gram, positive, negative, bacteria, Receptor, Antibiotics, Apoptosis, Inducers, 5359, Tocris Bioscience

Citations for Rifaximin

Citations are publications that use Tocris products.

Currently there are no citations for Rifaximin. Do you know of a great paper that uses Rifaximin from Tocris? Please let us know.

Reviews for Rifaximin

Average Rating: 4 (Based on 1 Review.)

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Rifaximin used in resistance study against E.Coli.
By Anonymous on 02/11/2019
Species: Human

Rifaximin was used against E.coli in comparison with Rifampine. Resistance study of E.coli was being carried out.

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