Discontinued Product

Rifaximin (Cat. No. 5359) has been withdrawn from sale for commercial reasons.
Description: Pregnane X receptor agonist; antibiotic
Chemical Name: (2S,16Z,18E,20S,21S,22R,23R,24R,25S,26R,27S,28E)-25-(Acetyloxy)-5,6,21,23-tetrahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-2,7-(epoxypentadeca[1,11,13]trienimino)benzofuro[4,5-e]pyrido[1,2-a]benzimidazole-1,15(2H)-dione
Purity: ≥98% (HPLC)
Reviews (1)
Literature (1)

Biological Activity for Rifaximin

Rifaximin is a pregnane X receptor (PXR) agonist; antibiotic. Reduces number of colon tumors and suppresses expression of TNFα and Il-1β induced in a colon cancer, PXR-humanized mouse model. Increases apoptosis and decreased proliferation in HT-29 cells. Exhibits low gastrointestinal absorption while retaining its antibacterial activity. Active against gram-positive and gram-negative bacteria.

Compound Libraries for Rifaximin

Rifaximin is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Rifaximin

M. Wt 785.88
Formula C43H51N3O11
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 80621-81-4
PubChem ID 6436173
Smiles O=C(/C(C)=C\C=C\[C@H](C)[C@H](O)[C@H]([C@H]([C@@H](C)[C@H](OC(C)=O)[C@H](C)[C@@H](OC)/C=C/O[C@@]5(C)O4)O)C)NC2=C(O)C1=C(O)C(C)=C4C(C5=O)=C1C3=C2N6C(C=C(C)C=C6)=N3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for Rifaximin

References are publications that support the biological activity of the product.

Cheng et al (2014) Activation of intestinal human pregnane X receptor protects against azoxymethane/dextran sulfate sodium-induced colon cancer. J.Pharmacol.Exp.Ther. 351 559 PMID: 25277138

Jiang et al (2005) Rifaximin: in vitro and in vivo antibacterial activity-a review. Chemotherapy 51 67 PMID: 15855749

Stradi et al (2010) Structural elucidation of the rifa. Ph. Eur. Impurity H. J.Pharm.Biomed.Anal. 51 858 PMID: 19926422

View Related Products by Product Action

View all Pregnane X Receptor Agonists

Keywords: Rifaximin, Rifaximin supplier, Antibiotic, Pregnane, X, receptors, agonists, PXR, colon, tumors, tumours, gram, positive, negative, bacteria, Receptor, Antibiotics, Apoptosis, Inducers, 5359, Tocris Bioscience

Citations for Rifaximin

Citations are publications that use Tocris products.

Currently there are no citations for Rifaximin.

Reviews for Rifaximin

Average Rating: 4 (Based on 1 Review.)

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Rifaximin used in resistance study against E.Coli.
By Anonymous on 02/11/2019
Species: Human

Rifaximin was used against E.coli in comparison with Rifampine. Resistance study of E.coli was being carried out.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Retinoid Receptors Scientific Review

Retinoid Receptors Scientific Review

Written by Alexander Moise, this review summarizes the nature of retinoid receptors, their isotype and isoform variants and modulation of retinoid signaling. Compounds available from Tocris are listed.