RI 1

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Cat.No. 6168 - RI 1 | C14H11Cl3N2O3 | CAS No. 415713-60-9
Description: RAD51 recombinase inhibitor
Chemical Name: 3-Chloro-1-(3,4-dichlorophenyl)-4-(4-morpholinyl)-1H-pyrrole-2,5-dione
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

RAD51 inhibitor (IC50 is in the range 5 - 30 μM). Covently binds C139 on protein surface. Inhibits homologous recombination. Cell permeable. Sensitizes tumor cells to chemotherapy.

Technical Data

M. Wt 361.61
Formula C14H11Cl3N2O3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 415713-60-9
PubChem ID 1074953
InChI Key MWSUIZKGNWELRF-UHFFFAOYSA-N
Smiles ClC1=C(C(N(C2=CC(Cl)=C(C=C2)Cl)C1=O)=O)N3CCOCC3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.16 100

Preparing Stock Solutions

The following data is based on the product molecular weight 361.61. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.77 mL 13.83 mL 27.65 mL
5 mM 0.55 mL 2.77 mL 5.53 mL
10 mM 0.28 mL 1.38 mL 2.77 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

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Product Datasheets

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References

References are publications that support the products' biological activity.

Budke et al (2012) RI-1: a chemical inhibitor of RAD51 that disrupts homologous recombination in human cells. Nucleic Acids Res. 40 7347 PMID: 22573178


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