RI 1

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Cat.No. 6168 - RI 1 | C14H11Cl3N2O3 | CAS No. 415713-60-9
Description: RAD51 recombinase inhibitor
Chemical Name: 3-Chloro-1-(3,4-dichlorophenyl)-4-(4-morpholinyl)-1H-pyrrole-2,5-dione
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for RI 1

RI 1 is a RAD51 inhibitor (IC50 is in the range 5 - 30 μM). Covently binds C139 on protein surface. Inhibits homologous recombination. Cell permeable. Sensitizes tumor cells to chemotherapy.

Technical Data for RI 1

M. Wt 361.61
Formula C14H11Cl3N2O3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 415713-60-9
PubChem ID 1074953
Smiles ClC1=C(C(N(C2=CC(Cl)=C(C=C2)Cl)C1=O)=O)N3CCOCC3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for RI 1

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 36.16 100

Preparing Stock Solutions for RI 1

The following data is based on the product molecular weight 361.61. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.77 mL 13.83 mL 27.65 mL
5 mM 0.55 mL 2.77 mL 5.53 mL
10 mM 0.28 mL 1.38 mL 2.77 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

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References for RI 1

References are publications that support the biological activity of the product.

Budke et al (2012) RI-1: a chemical inhibitor of RAD51 that disrupts homologous recombination in human cells. Nucleic Acids Res. 40 7347 PMID: 22573178

If you know of a relevant reference for RI 1, please let us know.

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Keywords: RI 1, RI 1 supplier, RI1, RAD51, recombinase, inhibitors, inhibits, HR, homologous, repair, chemosensitizers, chemosensitisers, DNA,, RNA, and, Protein, Synthesis, 6168, Tocris Bioscience

Citations for RI 1

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