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Biological Activity for RI 1
RI 1 is a RAD51 inhibitor (IC50 is in the range 5 - 30 μM). Covently binds C139 on protein surface. Inhibits homologous recombination. Cell permeable. Sensitizes tumor cells to chemotherapy.
Technical Data for RI 1
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for RI 1
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for RI 1
The following data is based on the product molecular weight 361.61. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.77 mL||13.83 mL||27.65 mL|
|5 mM||0.55 mL||2.77 mL||5.53 mL|
|10 mM||0.28 mL||1.38 mL||2.77 mL|
|50 mM||0.06 mL||0.28 mL||0.55 mL|
References for RI 1
References are publications that support the biological activity of the product.
Budke et al (2012) RI-1: a chemical inhibitor of RAD51 that disrupts homologous recombination in human cells. Nucleic Acids Res. 40 7347 PMID: 22573178
If you know of a relevant reference for RI 1, please let us know.
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Keywords: RI 1, RI 1 supplier, RI1, RAD51, recombinase, inhibitors, inhibits, HR, homologous, repair, chemosensitizers, chemosensitisers, DNA,, RNA, and, Protein, Synthesis, 6168, Tocris Bioscience
Citations for RI 1
Citations are publications that use Tocris products.
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Reviews for RI 1
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Literature in this Area
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