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Viral RNA-dependent RNA polymerase inhibitor (RdRp) and broad spectrum antiviral nucleotide prodrug. Metabolized to active form, GS 441524 (Cat. No. 7227). Exhibits activity against a range of RNA viruses in vitro (EC50 values are 0.019, 0.07, 0.07 - 0.34, 0.086 - 0.14, and 23.15 μM against RSV, SARS-CoV, MERS-CoV, EBOV and SARS-CoV-2, respectively). Exhibits antiviral efficacy in animal models of MERS-CoV and EBOV infection.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 602.58. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.66 mL||8.3 mL||16.6 mL|
|5 mM||0.33 mL||1.66 mL||3.32 mL|
|10 mM||0.17 mL||0.83 mL||1.66 mL|
|50 mM||0.03 mL||0.17 mL||0.33 mL|
References are publications that support the biological activity of the product.
Sheahan et al (2020) Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV. Nat.Commun. 11 222 PMID: 31924756
Warren et al (2016) Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys. Nature 531 381 PMID: 26934220
Choy et al (2020) Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2replication in vitro. Antiviral Res. 178 104786 PMID: 32251767
If you know of a relevant reference for Remdesivir, please let us know.
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