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Description: Viral RNA-dependent RNA polymerase (RdRP) inhibitor; broad spectrum antiviral nucleotide prodrug
Alternative Names: GS-5734
Chemical Name: 2-Ethylbutyl (2S)-2-[[(S)-[[(2R,3S,4R,5R)-5-(4-aminopyrrolo(2,1-f)(1,2,4)triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl]methoxy]phenoxyphosphoryl]amino]propanoate
Purity: ≥98% (HPLC)
Citations (2)

Biological Activity for Remdesivir

Remdesivir is a viral RNA-dependent RNA polymerase inhibitor (RdRp) and broad spectrum antiviral nucleotide prodrug. Metabolized to active form, GS 441524 (Cat. No. 7227). Exhibits activity against a range of RNA viruses in vitro (EC50 values are 0.019, 0.07, 0.07 - 0.34, 0.086 - 0.14, and 23.15 μM against RSV, SARS-CoV, MERS-CoV, EBOV and SARS-CoV-2, respectively). Exhibits antiviral efficacy in animal models of MERS-CoV and EBOV infection.

Compound Libraries for Remdesivir

Remdesivir is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library, Tocriscreen Epigenetics Library and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Remdesivir

M. Wt 602.58
Formula C27H35N6O8P
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1809249-37-3
PubChem ID 121304016
Smiles CCC(COC([C@@H](N[P@](OC[C@H]1O[C@]([C@@H]([C@@H]1O)O)(C2=CC=C3N2N=CN=C3N)C#N)(OC4=CC=CC=C4)=O)C)=O)CC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Remdesivir

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 60.26 100
ethanol 12.05 20

Preparing Stock Solutions for Remdesivir

The following data is based on the product molecular weight 602.58. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.66 mL 8.3 mL 16.6 mL
5 mM 0.33 mL 1.66 mL 3.32 mL
10 mM 0.17 mL 0.83 mL 1.66 mL
50 mM 0.03 mL 0.17 mL 0.33 mL

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Product Datasheets for Remdesivir

Certificate of Analysis / Product Datasheet
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References for Remdesivir

References are publications that support the biological activity of the product.

Sheahan et al (2020) Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV. Nat.Commun. 11 222 PMID: 31924756

Warren et al (2016) Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys. Nature 531 381 PMID: 26934220

Choy et al (2020) Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2replication in vitro. Antiviral Res. 178 104786 PMID: 32251767

If you know of a relevant reference for Remdesivir, please let us know.

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2 Citations for Remdesivir

Citations are publications that use Tocris products. Selected citations for Remdesivir include:

Marc et al (2023) A proteome-scale map of the SARS-CoV-2-human contactome. Nat Biotechnol 41 140-149 PMID: 36217029

Allison B et al (2022) Putative COVID-19 therapies imatinib, lopinavir, ritonavir, and ivermectin cause hair cell damage: A targeted screen in the zebrafish lateral line. Front Cell Neurosci 16 941031 PMID: 36090793

Do you know of a great paper that uses Remdesivir from Tocris? Please let us know.

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