GS 441524

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Cat.No. 7227 - GS 441524 | C12H13N5O4 | CAS No. 1191237-69-0
Description: Viral RNA-dependent RNA polymerase inhibitor; broad spectrum antiviral nucelotide
Chemical Name: (2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)

Biological Activity

Viral RNA-dependent RNA polymerase (RdRp) inhibitor and broad spectrum antiviral nucleotide; active metabolite of Remdesivir (Cat. No. 7226). Competes with natural nucleoside triphosphates, blocking viral RNA synthesis. Exhibits antiviral activity against viruses from Coronaviridae family including SARS-CoV-2 in vitro, and SARS-CoV and feline infectious peritonitis virus (FIPV) in vitro and in vivo. Inhibits SARS-CoV and MERS-CoV- infected HAE cultures (EC50 values are 0.18 and 0.86 μM, respectively) and inhibits murine hepatitis virus (MHV) (EC50 = 1.1 μM).

Technical Data

M. Wt 291.27
Formula C12H13N5O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1191237-69-0
PubChem ID 44468216
InChI Key BRDWIEOJOWJCLU-LTGWCKQJSA-N
Smiles OC[C@H]1O[C@]([C@@H]([C@@H]1O)O)(C2=CC=C3N2N=CN=C3N)C#N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 29.13 100

Preparing Stock Solutions

The following data is based on the product molecular weight 291.27. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.43 mL 17.17 mL 34.33 mL
5 mM 0.69 mL 3.43 mL 6.87 mL
10 mM 0.34 mL 1.72 mL 3.43 mL
50 mM 0.07 mL 0.34 mL 0.69 mL

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References

References are publications that support the biological activity of the product.

Agostini et al (2018) Coronavirus susceptibility to the antiviral Remdesivir (GS-5734) is mediated by the viral polymerase and the proofreading exoribonuclease mBio. 9 e00221 PMID: 29511076

Cho et al (2012) Synthesis and antiviral activity of a series of 1'-substituted 4-aza-7,9-dideazaadenosine C-nucleosides Bioorg.Med.Chem.Lett. 22 2705 PMID: 22446091


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Keywords: GS 441524, GS 441524 supplier, GS441524, Viral, RNA-dependent, RNA, polymerase, RdRp, inhibitors, inhibits, coronaviridae, coronaviruses, SARS-CoV-2, feline, infectious, peritonitis, virus, FIPV, Polymerase, COVID-19, Antivirals, 7227, Tocris Bioscience

Citations for GS 441524

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