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Biological Activity for GS 441524
GS 441524 is a viral RNA-dependent RNA polymerase (RdRp) inhibitor and broad spectrum antiviral nucleotide; active metabolite of Remdesivir (Cat. No. 7226). Competes with natural nucleoside triphosphates, blocking viral RNA synthesis. Exhibits antiviral activity against viruses from Coronaviridae family including SARS-CoV-2 in vitro, and SARS-CoV and feline infectious peritonitis virus (FIPV) in vitro and in vivo. Inhibits SARS-CoV and MERS-CoV- infected HAE cultures (EC50 values are 0.18 and 0.86 μM, respectively) and inhibits murine hepatitis virus (MHV) (EC50 = 1.1 μM).
Compound Libraries for GS 441524
Technical Data for GS 441524
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for GS 441524
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for GS 441524
The following data is based on the product molecular weight 291.27. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.43 mL||17.17 mL||34.33 mL|
|5 mM||0.69 mL||3.43 mL||6.87 mL|
|10 mM||0.34 mL||1.72 mL||3.43 mL|
|50 mM||0.07 mL||0.34 mL||0.69 mL|
References for GS 441524
References are publications that support the biological activity of the product.
Agostini et al (2018) Coronavirus susceptibility to the antiviral Remdesivir (GS-5734) is mediated by the viral polymerase and the proofreading exoribonuclease mBio. 9 e00221 PMID: 29511076
Cho et al (2012) Synthesis and antiviral activity of a series of 1'-substituted 4-aza-7,9-dideazaadenosine C-nucleosides Bioorg.Med.Chem.Lett. 22 2705 PMID: 22446091
If you know of a relevant reference for GS 441524, please let us know.
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Citations for GS 441524
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