Rasagiline mesylate

Pricing Availability Delivery Time Qty
Cat.No. 4308 - Rasagiline mesylate | C12H13N.CH3SO3H | CAS No. 161735-79-1
Description: Selective, irreversible MAO-B inhibitor
Chemical Name: (1R)-2,3-Dihydro-N-2-propynyl-1H-inden-1-amine methanesulfonate
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective irreversible MAO-B inhibitor. Displays antiParkinsonian activity; exhibits neuroprotective and antiapoptotic activity against several neurotoxins in cell culture.

Compound Libraries

Rasagiline mesylate is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 267.34
Formula C12H13N.CH3SO3H
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 161735-79-1
PubChem ID 3052775
InChI Key JDBJJCWRXSVHOQ-UTONKHPSSA-N
Smiles C#CCN[C@@H]2CCC1=CC=CC=C12.CS(=O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 26.73 100
water 26.73 100

Preparing Stock Solutions

The following data is based on the product molecular weight 267.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.74 mL 18.7 mL 37.41 mL
5 mM 0.75 mL 3.74 mL 7.48 mL
10 mM 0.37 mL 1.87 mL 3.74 mL
50 mM 0.07 mL 0.37 mL 0.75 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Finberg and Youdim (2002) Pharmacological properties of the anti-Parkinson drug rasagiline; modification of endogenous brain amines, reserpine reversal, serotonergic and dopaminergic behaviours. Neuropharmacology 43 1110 PMID: 12504917

Maruyama et al (2002) The anti-parkinson drug, rasagiline, prevents apoptotic DNA damage induced by peroxynitrite in human dopaminergic neuroblastoma SH-SY5Y cells. J.Neural Transm. 109 467 PMID: 11956966

Youdim and Weinstock (2002) Molecular basis of neuroprotective activities of rasagiline and the anti-Alzheimer drug TV3326 [(N-propargyl-(3R)aminoindan-5-YL)-ethyl methyl carbamate]. Cell.Mol.Neurobiol. 21 555 PMID:


If you know of a relevant reference for Rasagiline mesylate, please let us know.

View Related Products by Product Action

View all Monoamine Oxidase Inhibitors

Keywords: Rasagiline mesylate, supplier, Rasagiline, mesylate, monoamine, oxidases, mao-b, mao, b, inhibitors, inhibits, selective, antiparkinsons, antiparkinsonian, parkinson's, parkinsons, Monoamine, Oxidase, Tocris Bioscience

Citations for Rasagiline mesylate

Citations are publications that use Tocris products.

Currently there are no citations for Rasagiline mesylate. Do you know of a great paper that uses Rasagiline mesylate from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

Neurodegeneration

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease
Addiction

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.

Depression

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

Parkinson's

Parkinson's Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.

Pathways for Rasagiline mesylate

Protocols

TODO: Add Protocols