You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Inhibitor of the regulatory subunit PPP1R15B of protein phosphatase (Kd = 33 nM). Displays >30-fold selectivity for PPP1R15B over PPP1R15A. Inhibits PPP1R15B-mediated dephosphorylation and protein synthesis in vitro. Induces transient reduction in protein synthesis in brains of wild type mice after single dose. Decreases SDS-insoluble huntingtin assemblies and nuclear inclusions in a mouse model of Huntington's disease. Orally bioavailable and brain penetrant.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 231.08. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.33 mL||21.64 mL||43.28 mL|
|5 mM||0.87 mL||4.33 mL||8.66 mL|
|10 mM||0.43 mL||2.16 mL||4.33 mL|
|50 mM||0.09 mL||0.43 mL||0.87 mL|
References are publications that support the biological activity of the product.
Krzyzosiak et al (2018) Target-based discovery of an inhibitor of the regulatory phosphatase PPP1R15B. Cell. 174 1216 PMID: 30057111
If you know of a relevant reference for Raphin 1, please let us know.
View Related Products by Product Action
Keywords: Raphin 1, Raphin 1 supplier, Raphin1, protein, phosphatase, 1, regulatory, subunit, 15B, inhibitors, inhibits, synthesis, PPP1R15B, huntingtin, Protein, Ser/Thr, Phosphatases, 6760, Tocris Bioscience
Citations for Raphin 1
Citations are publications that use Tocris products.
Currently there are no citations for Raphin 1. Do you know of a great paper that uses Raphin 1 from Tocris? Please let us know.
Reviews for Raphin 1
There are currently no reviews for this product. Be the first to review Raphin 1 and earn rewards!
Have you used Raphin 1?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.