RAF 265

Pricing Availability   Qty
Cat.No. 6015 - RAF 265 | C24H16F6N6O | CAS No. 927880-90-8
Description: Raf kinase and VEGFR-2 inhibitor
Alternative Names: CHIR 265
Chemical Name: 1-Methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridinyl]oxy]-N-[4-(trifluoromethyl)phenyl]-1H-benzimidazol-2-amine
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Raf kinase and VEGFR-2 inhibitor. Inhibits c-Raf, wild type B-Raf and mutant B-Raf (V600E). Cytotoxic in certain melanoma cells lines. Effects enhanced by protein kinase D3 inhibition, preventing reactivation of MAPK signaling and increasing caspase activity. Orally bioavailable.

Technical Data

M. Wt 518.41
Formula C24H16F6N6O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 927880-90-8
PubChem ID 11656518
InChI Key YABJJWZLRMPFSI-UHFFFAOYSA-N
Smiles CN1C(NC2=CC=C(C=C2)C(F)(F)F)=NC3=CC(OC4=CC=NC(C5=NC=C(C(F)(F)F)N5)=C4)=CC=C13

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 51.84 100
ethanol 10.37 20

Preparing Stock Solutions

The following data is based on the product molecular weight 518.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.93 mL 9.64 mL 19.29 mL
5 mM 0.39 mL 1.93 mL 3.86 mL
10 mM 0.19 mL 0.96 mL 1.93 mL
50 mM 0.04 mL 0.19 mL 0.39 mL

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References

References are publications that support the biological activity of the product.

Chen et al (2011) Protein kinase D3 sensitizes RAF inhibitor RAF265 in melanoma cells by preventing reactivation of MAPK signaling. Cancer Res. 71 4280 PMID: 21527556


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Citations for RAF 265

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