RAF 265

Discontinued Product

RAF 265 (Cat. No. 6015) has been withdrawn from sale for commercial reasons.
Description: Raf kinase and VEGFR-2 inhibitor
Alternative Names: CHIR 265
Chemical Name: 1-Methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridinyl]oxy]-N-[4-(trifluoromethyl)phenyl]-1H-benzimidazol-2-amine
Purity: ≥98% (HPLC)

Biological Activity for RAF 265

RAF 265 is a Raf kinase and VEGFR-2 inhibitor. Inhibits c-Raf, wild type B-Raf and mutant B-Raf (V600E). Cytotoxic in certain melanoma cells lines. Effects enhanced by protein kinase D3 inhibition, preventing reactivation of MAPK signaling and increasing caspase activity. Orally bioavailable.

Technical Data for RAF 265

M. Wt 518.41
Formula C24H16F6N6O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 927880-90-8
PubChem ID 11656518
Smiles CN1C(NC2=CC=C(C=C2)C(F)(F)F)=NC3=CC(OC4=CC=NC(C5=NC=C(C(F)(F)F)N5)=C4)=CC=C13

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for RAF 265

References are publications that support the biological activity of the product.

Chen et al (2011) Protein kinase D3 sensitizes RAF inhibitor RAF265 in melanoma cells by preventing reactivation of MAPK signaling. Cancer Res. 71 4280 PMID: 21527556

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Keywords: RAF 265, RAF 265 supplier, RAF265, Raf, kinases, inhibitors, inhibits, B-Raf, c-Raf, VEGFR2, vascular, endothelial, growth, factor, cytotoxic, MAPK, CHIR, 265, Kinase, VEGFR, 6015, Tocris Bioscience

Citations for RAF 265

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Currently there are no citations for RAF 265.

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