You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
RA 2 New
Biological Activity for RA 2
RA 2 is a potent negative modulator of calcium-activated potassium channels KCa2.3 and KCa3.1 (IC50 values are 2 and 17 nM, respectively), which displays >55-fold selectively for KCa2 and KCa3.1 over other KCa, Kv and Kir channels. In ex vivo porcine coronary endothelium, RA 2 inhibits SKA 31 (Cat. No. 3670)-induced KCa2/KCa3.1 currents and TRAM 34 (Cat. No. 2946)-insensitive KCa2 currents. Reduces heart rate in mice in a KCa3.1-dependent manner.
Technical Data for RA 2
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for RA 2
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for RA 2
The following data is based on the product molecular weight 414.36. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.41 mL||12.07 mL||24.13 mL|
|5 mM||0.48 mL||2.41 mL||4.83 mL|
|10 mM||0.24 mL||1.21 mL||2.41 mL|
|50 mM||0.05 mL||0.24 mL||0.48 mL|
References for RA 2
References are publications that support the biological activity of the product.
Olivan-Viguera et al (2015) A novel pan-negative-gating modulator of KCa2/3 channels, fluoro-di-benzoate, RA-2, inhibits endothelium-derived hyperpolarization-type relaxation in coronary artery and produces bradycardia in vivo. Mol.Pharmacol. 338 PMID: 25468883
Olivan-Viguera et al (2016) Vascular reactivity profile of novel KCa3.1-selective positive-gating modulators in the coronary vascular bed. Basic Clin.Pharmacol.Toxicol. 119 184 PMID: 26821335
If you know of a relevant reference for RA 2, please let us know.
View Related Products by Product Action
Keywords: RA 2, RA 2 supplier, RA-2, negative, gating, modulator, KCa, 3.1, 2.3, Ik, SK, calcium, sensitive, activated, potassium, channels, Ca2+-Activated, Potassium, Channels, 7129, Tocris Bioscience
Citations for RA 2
Citations are publications that use Tocris products.
Currently there are no citations for RA 2. Do you know of a great paper that uses RA 2 from Tocris? Please let us know.
Reviews for RA 2
There are currently no reviews for this product. Be the first to review RA 2 and earn rewards!
Have you used RA 2?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.