RA 2

Pricing Availability   Qty
Description: Potent negative modulator of KCa2.3 and KCa3.1 channels
Chemical Name: 1,3-Phenylenebis(methylene)bis(3-fluoro-4-hydroxybenzoate)
Purity: ≥98% (HPLC)

Biological Activity for RA 2

RA 2 is a potent negative modulator of calcium-activated potassium channels KCa2.3 and KCa3.1 (IC50 values are 2 and 17 nM, respectively), which displays >55-fold selectively for KCa2 and KCa3.1 over other KCa, Kv and Kir channels. In ex vivo porcine coronary endothelium, RA 2 inhibits SKA 31 (Cat. No. 3670)-induced KCa2/KCa3.1 currents and TRAM 34 (Cat. No. 2946)-insensitive KCa2 currents. Reduces heart rate in mice in a KCa3.1-dependent manner.

Compound Libraries for RA 2

RA 2 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for RA 2

M. Wt 414.36
Formula C22H16F2O6
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1867107-62-7
Smiles OC1=C(C=C(C(OCC2=CC(COC(C3=CC(F)=C(C=C3)O)=O)=CC=C2)=O)C=C1)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for RA 2

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 41.44 100
ethanol 41.44 100

Preparing Stock Solutions for RA 2

The following data is based on the product molecular weight 414.36. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.41 mL 12.07 mL 24.13 mL
5 mM 0.48 mL 2.41 mL 4.83 mL
10 mM 0.24 mL 1.21 mL 2.41 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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References for RA 2

References are publications that support the biological activity of the product.

Olivan-Viguera et al (2015) A novel pan-negative-gating modulator of KCa2/3 channels, fluoro-di-benzoate, RA-2, inhibits endothelium-derived hyperpolarization-type relaxation in coronary artery and produces bradycardia in vivo. Mol.Pharmacol. 338 PMID: 25468883

Olivan-Viguera et al (2016) Vascular reactivity profile of novel KCa3.1-selective positive-gating modulators in the coronary vascular bed. Basic Clin.Pharmacol.Toxicol. 119 184 PMID: 26821335

If you know of a relevant reference for RA 2, please let us know.

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Keywords: RA 2, RA 2 supplier, RA-2, negative, gating, modulator, KCa, 3.1, 2.3, Ik, SK, calcium, sensitive, activated, potassium, channels, Ca2+-Activated, Potassium, Channels, 7129, Tocris Bioscience

Citations for RA 2

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