SKA 31

Pricing Availability Delivery Time Qty
Cat.No. 3670 - SKA 31 | C11H8N2S | CAS No. 40172-65-4
Description: Activator of KCa3.1 and KCa2 channels
Chemical Name: Naphtho[1,2-d]thiazol-2-ylamine
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Activator of KCa3.1 and KCa2 channels (EC50 values are 260, 2900, 2900 nM for KCa3.1, KCa2.1 and KCa2.2 respectively). Potentiates acetylcholine-induced EDHF-type dilations of mouse carotid arteries and lowers blood pressure in normotensive and hypertensive mice.

Compound Libraries

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Technical Data

M. Wt 200.26
Formula C11H8N2S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 40172-65-4
PubChem ID 94880
InChI Key FECQXVPRUCCUIL-UHFFFAOYSA-N
Smiles NC3=NC2=C(S3)C=CC1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 20.03 100
ethanol 20.03 100

Preparing Stock Solutions

The following data is based on the product molecular weight 200.26. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.99 mL 24.97 mL 49.94 mL
5 mM 1 mL 4.99 mL 9.99 mL
10 mM 0.5 mL 2.5 mL 4.99 mL
50 mM 0.1 mL 0.5 mL 1 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Sankaranarayanan et al (2009) Naphtho[1,2-d]thaizol-2-ylamine (SKA-31), a new activator of KCa2 and KCa3.1 potassium channels, potentiates the endothelium-derived hyperpolarizing factor response and lowers blood pressure. Mol.Pharmacol. 75 281 PMID: 18955585

Brahler et al (2009) Genetic deficit of SK3 and IK1 channels disrupts the endothelium-derived hyperpolarizing factor vasodilator pathway and causes hypertension. Circulation 119 2323 PMID: 19380617


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View Related Products by Product Action

View all Calcium-Activated Potassium (KCa) Channel Activators

Keywords: Activators KCa3.1 KCa2.1 KCa2.2 Ca2+-activated potassium K+ channels SK1 SK2 small conductance SKA31 Ca2+-Activated Potassium Channels

Citations for SKA 31

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New Product Guide (Spring/Summer 2017)

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