SKA 31
Biological Activity
Activator of KCa3.1 and KCa2 channels (EC50 values are 260, 2900, 2900 nM for KCa3.1, KCa2.1 and KCa2.2 respectively). Potentiates acetylcholine-induced EDHF-type dilations of mouse carotid arteries and lowers blood pressure in normotensive and hypertensive mice.
Compound Libraries
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Technical Data
| M. Wt | 200.26 |
| Formula | C11H8N2S |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 40172-65-4 |
| PubChem ID | 94880 |
| InChI Key | FECQXVPRUCCUIL-UHFFFAOYSA-N |
| Smiles | NC3=NC2=C(S3)C=CC1=CC=CC=C12 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 20.03 | 100 | |
| ethanol | 20.03 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 200.26. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.99 mL | 24.97 mL | 49.94 mL |
| 5 mM | 1 mL | 4.99 mL | 9.99 mL |
| 10 mM | 0.5 mL | 2.5 mL | 4.99 mL |
| 50 mM | 0.1 mL | 0.5 mL | 1 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Sankaranarayanan et al (2009) Naphtho[1,2-d]thaizol-2-ylamine (SKA-31), a new activator of KCa2 and KCa3.1 potassium channels, potentiates the endothelium-derived hyperpolarizing factor response and lowers blood pressure. Mol.Pharmacol. 75 281 PMID: 18955585
Brahler et al (2009) Genetic deficit of SK3 and IK1 channels disrupts the endothelium-derived hyperpolarizing factor vasodilator pathway and causes hypertension. Circulation 119 2323 PMID: 19380617
If you know of a relevant reference for SKA 31, please let us know.
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Keywords: Activators KCa3.1 KCa2.1 KCa2.2 Ca2+-activated potassium K+ channels SK1 SK2 small conductance SKA31 Ca2+-Activated Potassium Channels
Citations for SKA 31
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Literature in this Area
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