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Submit ReviewActivator of KCa3.1 and KCa2 channels (EC50 values are 260, 2900, 2900 nM for KCa3.1, KCa2.1 and KCa2.2 respectively). Potentiates acetylcholine-induced EDHF-type dilations of mouse carotid arteries and lowers blood pressure in normotensive and hypertensive mice.
SKA 31 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
M. Wt | 200.26 |
Formula | C11H8N2S |
Storage | Store at +4°C |
Purity | ≥99% (HPLC) |
CAS Number | 40172-65-4 |
PubChem ID | 94880 |
InChI Key | FECQXVPRUCCUIL-UHFFFAOYSA-N |
Smiles | NC3=NC2=C(S3)C=CC1=CC=CC=C12 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
DMSO | 20.03 | 100 | |
ethanol | 20.03 | 100 |
The following data is based on the product molecular weight 200.26. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 4.99 mL | 24.97 mL | 49.94 mL |
5 mM | 1 mL | 4.99 mL | 9.99 mL |
10 mM | 0.5 mL | 2.5 mL | 4.99 mL |
50 mM | 0.1 mL | 0.5 mL | 1 mL |
References are publications that support the biological activity of the product.
Sankaranarayanan et al (2009) Naphtho[1,2-d]thaizol-2-ylamine (SKA-31), a new activator of KCa2 and KCa3.1 potassium channels, potentiates the endothelium-derived hyperpolarizing factor response and lowers blood pressure. Mol.Pharmacol. 75 281 PMID: 18955585
Brahler et al (2009) Genetic deficit of SK3 and IK1 channels disrupts the endothelium-derived hyperpolarizing factor vasodilator pathway and causes hypertension. Circulation 119 2323 PMID: 19380617
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View all Calcium-Activated Potassium (KCa) Channel Activators
Keywords: SKA 31, SKA 31 supplier, Activators, KCa3.1, KCa2.1, KCa2.2, Ca2+-activated, potassium, K+, channels, SK1, SK2, small, conductance, SKA31, Ca2+-Activated, Potassium, Channels, 3670, Tocris Bioscience
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Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.