SKA 31

Pricing Availability   Qty
Description: KCa3.1 (IK) and KCa2 (SK) channel activator
Chemical Name: Naphtho[1,2-d]thiazol-2-ylamine
Purity: ≥99% (HPLC)
Reviews (1)

Biological Activity for SKA 31

SKA 31 is an activator of KCa3.1 and KCa2 channels (EC50 values are 260, 2900, 2900 nM for KCa3.1, KCa2.1 and KCa2.2 respectively). Potentiates acetylcholine-induced EDHF-type dilations of mouse carotid arteries and lowers blood pressure in normotensive and hypertensive mice.

Compound Libraries for SKA 31

SKA 31 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SKA 31

M. Wt 200.26
Formula C11H8N2S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 40172-65-4
PubChem ID 94880
Smiles NC3=NC2=C(S3)C=CC1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SKA 31

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 20.03 100
ethanol 20.03 100

Preparing Stock Solutions for SKA 31

The following data is based on the product molecular weight 200.26. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.99 mL 24.97 mL 49.94 mL
5 mM 1 mL 4.99 mL 9.99 mL
10 mM 0.5 mL 2.5 mL 4.99 mL
50 mM 0.1 mL 0.5 mL 1 mL

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References for SKA 31

References are publications that support the biological activity of the product.

Sankaranarayanan et al (2009) Naphtho[1,2-d]thaizol-2-ylamine (SKA-31), a new activator of KCa2 and KCa3.1 potassium channels, potentiates the endothelium-derived hyperpolarizing factor response and lowers blood pressure. Mol.Pharmacol. 75 281 PMID: 18955585

Brahler et al (2009) Genetic deficit of SK3 and IK1 channels disrupts the endothelium-derived hyperpolarizing factor vasodilator pathway and causes hypertension. Circulation 119 2323 PMID: 19380617

If you know of a relevant reference for SKA 31, please let us know.

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Citations for SKA 31

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Reviews for SKA 31

Average Rating: 5 (Based on 1 Review.)

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SKA 31 is a great channel activator and works well on biological lab conditions.
By Anonymous on 10/13/2018
Assay Type: In Vitro
Species: Human

Great product for studies on Kca channel opening as a measure to compare between other activators. Would use again and suggest to others.

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