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Cat.No. 2946 - TRAM 34 | C22H17ClN2 | CAS No. 289905-88-0
Description: Potent and highly selective KCa3.1 (IK) channel blocker
Chemical Name: 1-[(2-Chlorophenyl)diphenylmethyl]-1H-pyrazole
Purity: ≥99% (HPLC)
Citations (10)
Reviews (1)
Literature (2)

Biological Activity for TRAM 34

TRAM 34 is a potent and highly selective blocker of intermediate conductance Ca2+-activated K+ channels (KCa3.1) (Kd = 20 nM). Exhibits 200-1500-fold selectivity over KV, BKCa, KCa2, Na+, CRAC and Cl- channels. Suppresses the reactivation of lymphocytes by mitogenic stimuli.

Technical Data for TRAM 34

M. Wt 344.84
Formula C22H17ClN2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 289905-88-0
PubChem ID 656734
Smiles ClC(C=CC=C4)=C4C(N2C=CC=N2)(C3=CC=CC=C3)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TRAM 34

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 3.45 10 with gentle warming

Preparing Stock Solutions for TRAM 34

The following data is based on the product molecular weight 344.84. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 29 mL 144.99 mL 289.99 mL
0.5 mM 5.8 mL 29 mL 58 mL
1 mM 2.9 mL 14.5 mL 29 mL
5 mM 0.58 mL 2.9 mL 5.8 mL

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Product Datasheets for TRAM 34

Certificate of Analysis / Product Datasheet
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References for TRAM 34

References are publications that support the biological activity of the product.

Schilling and Eder (2007) TRAM-34 inhibits nonselective cation channels. Pflugers Arch. 454 559 PMID: 17318643

Wang et al (2007) An intermediate-conductance Ca2+-activated K+ channel mediates B lymphoma cell cycle progression induced by serum. Pflugers Arch. 454 945 PMID: 17429684

Wulff et al (2000) Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: a potential immunosuppressant. Proc.Natl.Acad.Sci. USA 97 8151

If you know of a relevant reference for TRAM 34, please let us know.

View Related Products by Product Action

View all Calcium-Activated Potassium (KCa) Channel Blockers

Keywords: TRAM 34, TRAM 34 supplier, selective, IKCa1, channel, blockers, Potassium, KCa, Channels, ca2+-activated, ca2+-dependent, K+, TRAM34, KCa3.1, Ca2+-Activated, 2946, Tocris Bioscience

10 Citations for TRAM 34

Citations are publications that use Tocris products. Selected citations for TRAM 34 include:

Engbers et al (2012) Intermediate conductance calcium-activated potassium channels modulate summation of parallel fiber input in cerebellar Purkinje cells. Elife 109 2601 PMID: 22308379

Benton et al (2013) Iberiotoxin-sensitive and -insensitive BK currents in Purkinje neuron somata. J Neurophysiol 109 2528 PMID: 23446695

Chien and Su (2015) 5-hydroxytryptamine has an endothelium-derived hyperpolarizing factor-like effect on coronary flow in isolated rat hearts. PLoS One 22 42 PMID: 26076928

Mazzuca et al (2015) Estrogen receptor subtypes mediate distinct microvascular dilation and reduction in [Ca2+]I in mesenteric microvessels of female rat. J Pharmacol Exp Ther 352 291 PMID: 25472954

Do you know of a great paper that uses TRAM 34 from Tocris? Please let us know.

Reviews for TRAM 34

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TRAM 34 worked ideally as a channel blocker on different cell lines.
By Sadequl Islam on 10/13/2018
Assay Type: In Vitro
Species: Human

Product used for understanding blocking mechanism of calcium activated potassium channel. Product must be dissolved in DMSO, on mild heat. Shows great potential for research in KCa channel studies.

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