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Cat.No. 5969 - (R)-CE3F4 | C11H10Br2FNO | CAS No. 1593478-56-8
Description: Epac inhibitor
Chemical Name: (2R)-5,7-Dibromo-6-fluoro-3,4-dihydro-2-methyl-1(2H)-quinolinecarboxaldehyde
Purity: ≥98% (HPLC)

Biological Activity

Epac inhibitor (IC50 values are 4.2 and 44 μM for Epac1 and Epac2(B), respectively). Blocks activation of Epac by cAMP. This is the R-enantiomer of CE3F4 (Cat.No.4793).

Licensing Information

Sold for research use only under license from Inserm, Université Toulouse III - Paul Sabatier, Université Paris-Sud and Université d′Orléans.

Technical Data

M. Wt 351.01
Formula C11H10Br2FNO
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1593478-56-8
PubChem ID 73669655
Smiles BrC1=C(F)C(Br)=C(CC[C@@H](C)N2C=O)C2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 35.1 100
ethanol 17.55 50

Preparing Stock Solutions

The following data is based on the product molecular weight 351.01. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.85 mL 14.24 mL 28.49 mL
5 mM 0.57 mL 2.85 mL 5.7 mL
10 mM 0.28 mL 1.42 mL 2.85 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Courilleau et al (2013) The (R)-enantiomer of CE3F4 is a preferential inhibitor of human exchange protein directly activated by cyclic AMP isoform 1 (Epac1). Biochem.Biophys.Res.Commun. 440 443 PMID: 24099776

If you know of a relevant reference for (R)-CE3F4, please let us know.

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Keywords: (R)-CE3F4, supplier, Epac, antagonists, antagonism, R-enantiomer, cAMP, Rap1, guanine-nucleotide, exhange, factor, GEF, GTPase, GTPase, Tocris Bioscience

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