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Description: Epac inhibitor; R-enantiomer of CE3F4 (Cat. No. 4793)
Chemical Name: (2R)-5,7-Dibromo-6-fluoro-3,4-dihydro-2-methyl-1(2H)-quinolinecarboxaldehyde
Purity: ≥98% (HPLC)
Biological Activity for (R)-CE3F4
(R)-CE3F4 is an Epac inhibitor (IC50 values are 4.2 and 44 μM for Epac1 and Epac2(B), respectively). Blocks activation of Epac by cAMP. This is the R-enantiomer of CE3F4 (Cat.No.4793).
Licensing Information
Sold for research use only under license from Inserm, Université Toulouse III - Paul Sabatier, Université Paris-Sud and Université d′Orléans.
Technical Data for (R)-CE3F4
| M. Wt | 351.01 |
| Formula | C11H10Br2FNO |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1593478-56-8 |
| PubChem ID | 73669655 |
| InChI Key | ZZLQPWXVZCPUGC-ZCFIWIBFSA-N |
| Smiles | BrC1=C(F)C(Br)=C(CC[C@@H](C)N2C=O)C2=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for (R)-CE3F4
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 35.1 | 100 | |
| ethanol | 17.55 | 50 |
Preparing Stock Solutions for (R)-CE3F4
The following data is based on the product molecular weight 351.01. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.85 mL | 14.24 mL | 28.49 mL |
| 5 mM | 0.57 mL | 2.85 mL | 5.7 mL |
| 10 mM | 0.28 mL | 1.42 mL | 2.85 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.57 mL |
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Product Datasheets for (R)-CE3F4
References for (R)-CE3F4
References are publications that support the biological activity of the product.
Courilleau et al (2013) The (R)-enantiomer of CE3F4 is a preferential inhibitor of human exchange protein directly activated by cyclic AMP isoform 1 (Epac1). Biochem.Biophys.Res.Commun. 440 443 PMID: 24099776
Boulton et al (2018) Mechanism of selective enzyme inhibition through uncompetitive regulation of an allosteric agonist. J.Am.Chem.Soc. 140 9624 PMID: 30016089
If you know of a relevant reference for (R)-CE3F4, please let us know.
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Keywords: (R)-CE3F4, (R)-CE3F4 supplier, Epac, antagonists, antagonism, R-enantiomer, cAMP, Rap1, guanine-nucleotide, exhange, factor, GEF, RAPGEF3, EPAC, 5969, Tocris Bioscience
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