(R)-CE3F4

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Cat.No. 5969 - (R)-CE3F4 | C11H10Br2FNO | CAS No. 1593478-56-8
Description: Epac inhibitor; R-enantiomer of CE3F4 (Cat. No. 4793)
Chemical Name: (2R)-5,7-Dibromo-6-fluoro-3,4-dihydro-2-methyl-1(2H)-quinolinecarboxaldehyde
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Epac inhibitor (IC50 values are 4.2 and 44 μM for Epac1 and Epac2(B), respectively). Blocks activation of Epac by cAMP. This is the R-enantiomer of CE3F4 (Cat.No.4793).

Licensing Information

Sold for research use only under license from Inserm, Université Toulouse III - Paul Sabatier, Université Paris-Sud and Université d′Orléans.

Technical Data

M. Wt 351.01
Formula C11H10Br2FNO
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1593478-56-8
PubChem ID 73669655
InChI Key ZZLQPWXVZCPUGC-ZCFIWIBFSA-N
Smiles BrC1=C(F)C(Br)=C(CC[C@@H](C)N2C=O)C2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 17.55 50
DMSO 35.1 100

Preparing Stock Solutions

The following data is based on the product molecular weight 351.01. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.85 mL 14.24 mL 28.49 mL
5 mM 0.57 mL 2.85 mL 5.7 mL
10 mM 0.28 mL 1.42 mL 2.85 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

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References

References are publications that support the biological activity of the product.

Courilleau et al (2013) The (R)-enantiomer of CE3F4 is a preferential inhibitor of human exchange protein directly activated by cyclic AMP isoform 1 (Epac1). Biochem.Biophys.Res.Commun. 440 443 PMID: 24099776

Boulton et al (2018) Mechanism of selective enzyme inhibition through uncompetitive regulation of an allosteric agonist. J.Am.Chem.Soc. 140 9624 PMID: 30016089


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Keywords: (R)-CE3F4, (R)-CE3F4 supplier, Epac, antagonists, antagonism, R-enantiomer, cAMP, Rap1, guanine-nucleotide, exhange, factor, GEF, RAPGEF3, EPAC, 5969, Tocris Bioscience

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