(R)-CE3F4
Biological Activity
Epac inhibitor (IC50 values are 4.2 and 44 μM for Epac1 and Epac2(B), respectively). Blocks activation of Epac by cAMP. This is the R-enantiomer of CE3F4 (Cat.No.4793).
Licensing Information
Sold for research use only under license from Inserm, Université Toulouse III - Paul Sabatier, Université Paris-Sud and Université d′Orléans.
Technical Data
| M. Wt | 351.01 |
| Formula | C11H10Br2FNO |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1593478-56-8 |
| PubChem ID | 73669655 |
| InChI Key | ZZLQPWXVZCPUGC-ZCFIWIBFSA-N |
| Smiles | BrC1=C(F)C(Br)=C(CC[C@@H](C)N2C=O)C2=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| ethanol | 17.55 | 50 | |
| DMSO | 35.1 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 351.01. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.85 mL | 14.24 mL | 28.49 mL |
| 5 mM | 0.57 mL | 2.85 mL | 5.7 mL |
| 10 mM | 0.28 mL | 1.42 mL | 2.85 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.57 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the biological activity of the product.
Courilleau et al (2013) The (R)-enantiomer of CE3F4 is a preferential inhibitor of human exchange protein directly activated by cyclic AMP isoform 1 (Epac1). Biochem.Biophys.Res.Commun. 440 443 PMID: 24099776
Boulton et al (2018) Mechanism of selective enzyme inhibition through uncompetitive regulation of an allosteric agonist. J.Am.Chem.Soc. 140 9624 PMID: 30016089
If you know of a relevant reference for (R)-CE3F4, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: (R)-CE3F4, (R)-CE3F4 supplier, Epac, antagonists, antagonism, R-enantiomer, cAMP, Rap1, guanine-nucleotide, exhange, factor, GEF, RAPGEF3, EPAC, 5969, Tocris Bioscience
Citations for (R)-CE3F4
Citations are publications that use Tocris products.
Currently there are no citations for (R)-CE3F4. Do you know of a great paper that uses (R)-CE3F4 from Tocris? Please let us know.
Reviews for (R)-CE3F4
There are currently no reviews for this product. Be the first to review (R)-CE3F4 and earn rewards!
Have you used (R)-CE3F4?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
New Product Guide (Spring/Summer 2018)
Our new product guide highlights over 200 new products added to the Tocris Bioscience range during the second half of 2017.
- 7-TM Receptors
- Enzymes
- Enzyme-Linked Receptors
- Ion Channels
- Nuclear Receptors
- Transporters
- Aptamers
- Cell Metabolism
- Epigenetics
- Fluorescent Imaging
- Signal Transduction
- Stem Cells
