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Submit ReviewQuinine hydrochloride
Description: Antimalarial
Chemical Name: (R)-(6-Methoxyquinolin-4-yl)((2S,4S,8R)- 8-vinylquinuclidin-2-yl)methanol hydrochloride
Biological Activity for Quinine hydrochloride
Quinine hydrochloride displays antimalarial and muscle relaxant properties. Stereoisomer of quinidine (Cat. No. 4108); closely related to chloroquine (Cat. No. 4109).
Technical Data for Quinine hydrochloride
| M. Wt | 360.88 |
| Formula | C20H24N2O2.HCl |
| Storage | Store at -20°C |
| CAS Number | 130-89-2 |
| PubChem ID | 23424067 |
| InChI Key | LBSFSRMTJJPTCW-CYAVNPPASA-N |
| Smiles | O[C@@H](C3N(CC4C=C)CCC4C3)C2=CC=NC1=CC=C(OC)C=C12.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Quinine hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 36.09 | 100 | |
| DMSO | 36.09 | 100 |
Preparing Stock Solutions for Quinine hydrochloride
The following data is based on the product molecular weight 360.88. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.77 mL | 13.86 mL | 27.71 mL |
| 5 mM | 0.55 mL | 2.77 mL | 5.54 mL |
| 10 mM | 0.28 mL | 1.39 mL | 2.77 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.55 mL |
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Product Datasheets for Quinine hydrochloride
References for Quinine hydrochloride
References are publications that support the biological activity of the product.
Merck Index 14 8061
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Keywords: Quinine hydrochloride, Quinine hydrochloride supplier, antimalarial, muscle, relaxant, Antimalarials, 4114, Tocris Bioscience
1 Citation for Quinine hydrochloride
Citations are publications that use Tocris products. Selected citations for Quinine hydrochloride include:
Kawai et al (2022) Median raphe serotonergic neurons projecting to the interpeduncular nucleus control preference and aversion. Nat.Commun. 13 7708 PMID: 36550097
Do you know of a great paper that uses Quinine hydrochloride from Tocris? Please let us know.
Reviews for Quinine hydrochloride
Average Rating: 5 (Based on 1 Review.)
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Quinine was used along with penicillin derivatives to treat co-existance of malaria.
By
Anonymous on 02/20/2019
Species: Human
Use of antibacterials and antimalarials is common in the tropics because malaria is frequently associated with other infections.Quinine was used along with penicillin derivatives to treat co-existance of malaria.
