Quinidine

Pricing Availability Delivery Time Qty
Cat.No. 4108 - Quinidine | C20H24N2O2 | CAS No. 56-54-2
Description: Blocks sodium and potassium channels
Chemical Name: (S)-(6-Methoxyquinolin-4-yl)((2R,4S,8R)- 8-vinylquinuclidin-2-yl)methanol hydrochloride
Datasheet
Citations
Literature

Biological Activity

Class IA antiarrythmic; reduces both Na+ and K+ channel currents, including INa, IKr and IKs. Prolongs QT and induces torsade de pointes (TdP).

Technical Data

M. Wt 324.42
Formula C20H24N2O2
Storage Store at -20°C
CAS Number 56-54-2
PubChem ID 3036746
InChI Key LOUPRKONTZGTKE-LHFMAAMQSA-N
Smiles O[C@H](C3N(CC4C=C)CCC4C3)C2=CC=NC1=CC=C(OC)C=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 32.44 100
ethanol 8.11 25

Preparing Stock Solutions

The following data is based on the product molecular weight 324.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.08 mL 15.41 mL 30.82 mL
5 mM 0.62 mL 3.08 mL 6.16 mL
10 mM 0.31 mL 1.54 mL 3.08 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Caballero et al (2003) Effects of flecainide and quinidine on Kv4.2 currents: voltage dependence and role of S6 valines. Br.J.Pharmacol. 138 1475 PMID: 12721103

Borggrefe et al (2005) Short QT syndrome genotype-genotype correlations. J.Electrocardiol. 38 75 PMID: 16226079

Wu et al (2008) Role of late sodium current in modulating the proarrhythmic and antiarrhythmic effects of quinidine. Heart Rhythm. 5 1726 PMID: 19084812


If you know of a relevant reference for Quinidine, please let us know.

View Related Products by Target

Keywords: Quinidine, supplier, sodium, Na+, potassium, K+, channel, blockers, IKr, IKs, IK1, IK-ATP, Ito, INa, antiarrhythmic, class, 1A, torsade, de, pointes, prolongs, qt, interval, Other, Channel, Modulators, Other, Channel, Modulators, Tocris Bioscience

Citations for Quinidine

Citations are publications that use Tocris products.

Currently there are no citations for Quinidine. Do you know of a great paper that uses Quinidine from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

New Product Guide

New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Apoptosis
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells

Pathways for Quinidine

Protocols

TODO: Add Protocols