Quinidine

Pricing Availability   Qty
Cat.No. 4108 - Quinidine | C20H24N2O2 | CAS No. 56-54-2
Description: Blocks sodium and potassium channels
Chemical Name: (S)-(6-Methoxyquinolin-4-yl)((2R,4S,8R)- 8-vinylquinuclidin-2-yl)methanol hydrochloride
Datasheet
Citations (2)
Reviews (1)
Literature

Biological Activity

Class IA antiarrythmic; reduces both Na+ and K+ channel currents, including INa, IKr and IKs. Prolongs QT and induces torsade de pointes (TdP).

Technical Data

M. Wt 324.42
Formula C20H24N2O2
Storage Store at -20°C
CAS Number 56-54-2
PubChem ID 3036746
InChI Key LOUPRKONTZGTKE-LHFMAAMQSA-N
Smiles O[C@H](C3N(CC4C=C)CCC4C3)C2=CC=NC1=CC=C(OC)C=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 32.44 100
ethanol 8.11 25

Preparing Stock Solutions

The following data is based on the product molecular weight 324.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.08 mL 15.41 mL 30.82 mL
5 mM 0.62 mL 3.08 mL 6.16 mL
10 mM 0.31 mL 1.54 mL 3.08 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

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References

References are publications that support the biological activity of the product.

Caballero et al (2003) Effects of fleca. and q.dine on Kv4.2 currents: voltage dependence and role of S6 valines. Br.J.Pharmacol. 138 1475 PMID: 12721103

Borggrefe et al (2005) Short QT syndrome genotype-genotype correlations. J.Electrocardiol. 38 75 PMID: 16226079

Wu et al (2008) Role of late sodium current in modulating the proarrhythmic and antiarrhythmic effects of q.dine Heart Rhythm. 5 1726 PMID: 19084812


If you know of a relevant reference for Quinidine, please let us know.

View Related Products by Target

Keywords: Quinidine, Quinidine supplier, sodium, Na+, potassium, K+, channel, blockers, IKr, IKs, IK1, IK-ATP, Ito, INa, antiarrhythmic, class, 1A, torsade, de, pointes, prolongs, qt, interval, Other, Channel, Modulators, 4108, Tocris Bioscience

2 Citations for Quinidine

Citations are publications that use Tocris products. Selected citations for Quinidine include:

He et al (2017) Downregulation of miR-7116-5p in microglia by MPP+ sensitizes TNF-α production to induce dopaminergic neuron damage. Glia 65 1251 PMID: 28543680

Kim et al (2016) Targeting cancer metabolism by simultaneously disrupting parallel nutrient access pathways. J Clin Invest 126 4088 PMID: 27669461


Do you know of a great paper that uses Quinidine from Tocris? Please let us know.

Reviews for Quinidine

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Product was used on voltage gated potassium channels Kv11.1 and Kv7.1.
By Anonymous on 12/21/2018
Species: Human

Product was used on voltage gated potassium channels (Kv11.1 and Kv7.1) to understand blocking effect.

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Literature in this Area

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