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Description: Blocks sodium and potassium channels
Chemical Name: (S)-(6-Methoxyquinolin-4-yl)((2R,4S,8R)- 8-vinylquinuclidin-2-yl)methanol hydrochloride
Citations (5)
Reviews (2)

Biological Activity for Quinidine

Quinidine is a class IA antiarrythmic; reduces both Na+ and K+ channel currents, including INa, IKr and IKs. Prolongs QT and induces torsade de pointes (TdP).

Technical Data for Quinidine

M. Wt 324.42
Formula C20H24N2O2
Storage Store at -20°C
CAS Number 56-54-2
PubChem ID 3036746
Smiles O[C@H](C3N(CC4C=C)CCC4C3)C2=CC=NC1=CC=C(OC)C=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Quinidine

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 32.44 100
ethanol 8.11 25

Preparing Stock Solutions for Quinidine

The following data is based on the product molecular weight 324.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.08 mL 15.41 mL 30.82 mL
5 mM 0.62 mL 3.08 mL 6.16 mL
10 mM 0.31 mL 1.54 mL 3.08 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

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References for Quinidine

References are publications that support the biological activity of the product.

Caballero et al (2003) Effects of fleca. and q.dine on Kv4.2 currents: voltage dependence and role of S6 valines. Br.J.Pharmacol. 138 1475 PMID: 12721103

Borggrefe et al (2005) Short QT syndrome genotype-genotype correlations. J.Electrocardiol. 38 75 PMID: 16226079

Wu et al (2008) Role of late sodium current in modulating the proarrhythmic and antiarrhythmic effects of q.dine Heart Rhythm. 5 1726 PMID: 19084812

If you know of a relevant reference for Quinidine, please let us know.

View Related Products by Target

Keywords: Quinidine, Quinidine supplier, sodium, Na+, potassium, K+, channel, blockers, IKr, IKs, IK1, IK-ATP, Ito, INa, antiarrhythmic, class, 1A, torsade, de, pointes, prolongs, qt, interval, Other, Channel, Modulators, 4108, Tocris Bioscience

5 Citations for Quinidine

Citations are publications that use Tocris products. Selected citations for Quinidine include:

He et al (2017) Downregulation of miR-7116-5p in microglia by MPP+ sensitizes TNF-α production to induce dopaminergic neuron damage. Glia 65 1251 PMID: 28543680

Ting-Xin et al (2021) Global feather orientations changed by electric current. iScience 24 102671 PMID: 34179734

Jean-Didier et al (2017) GABAB receptors in neocortical and hippocampal pyramidal neurons are coupled to different potassium channels. Eur J Neurosci 46 2859-2866 PMID: 29131436

Kim et al (2016) Targeting cancer metabolism by simultaneously disrupting parallel nutrient access pathways. J Clin Invest 126 4088 PMID: 27669461

Do you know of a great paper that uses Quinidine from Tocris? Please let us know.

Reviews for Quinidine

Average Rating: 5 (Based on 2 Reviews.)

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Also a non-competitive alpha-1 adrenoceptor antagonist.
By Alex Voisey on 12/15/2020
Assay Type: In Vitro
Species: Rat

Excellent for blocking organic cation transport at 50 uM in rat aorta. However also acts as non-competitive antagonist of alpha-1 adrenoceptors. This is evidenced by the fact it can block vasoconstrictor responses induced by the alpha-1 adrenoceptor agonist phenylephrine in a non-competitive manner.

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Product was used on voltage gated potassium channels Kv11.1 and Kv7.1.
By Anonymous on 12/21/2018
Species: Human

Product was used on voltage gated potassium channels (Kv11.1 and Kv7.1) to understand blocking effect.

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