Quinidine

Pricing Availability   Qty
Cat.No. 4108 - Quinidine | C20H24N2O2 | CAS No. 56-54-2
Description: Blocks sodium and potassium channels
Chemical Name: (S)-(6-Methoxyquinolin-4-yl)((2R,4S,8R)- 8-vinylquinuclidin-2-yl)methanol hydrochloride
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Class IA antiarrythmic; reduces both Na+ and K+ channel currents, including INa, IKr and IKs. Prolongs QT and induces torsade de pointes (TdP).

Technical Data

M. Wt 324.42
Formula C20H24N2O2
Storage Store at -20°C
CAS Number 56-54-2
PubChem ID 3036746
InChI Key LOUPRKONTZGTKE-LHFMAAMQSA-N
Smiles O[C@H](C3N(CC4C=C)CCC4C3)C2=CC=NC1=CC=C(OC)C=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 32.44 100
ethanol 8.11 25

Preparing Stock Solutions

The following data is based on the product molecular weight 324.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.08 mL 15.41 mL 30.82 mL
5 mM 0.62 mL 3.08 mL 6.16 mL
10 mM 0.31 mL 1.54 mL 3.08 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References

References are publications that support the biological activity of the product.

Caballero et al (2003) Effects of flecainide and quinidine on Kv4.2 currents: voltage dependence and role of S6 valines. Br.J.Pharmacol. 138 1475 PMID: 12721103

Borggrefe et al (2005) Short QT syndrome genotype-genotype correlations. J.Electrocardiol. 38 75 PMID: 16226079

Wu et al (2008) Role of late sodium current in modulating the proarrhythmic and antiarrhythmic effects of quinidine. Heart Rhythm. 5 1726 PMID: 19084812


If you know of a relevant reference for Quinidine, please let us know.

View Related Products by Target

Keywords: Quinidine, Quinidine supplier, sodium, Na+, potassium, K+, channel, blockers, IKr, IKs, IK1, IK-ATP, Ito, INa, antiarrhythmic, class, 1A, torsade, de, pointes, prolongs, qt, interval, Other, Channel, Modulators, 4108, Tocris Bioscience

1 Citation for Quinidine

Citations are publications that use Tocris products. Selected citations for Quinidine include:

Kim et al (2016) Targeting cancer metabolism by simultaneously disrupting parallel nutrient access pathways. J Clin Invest 126 4088 PMID: 27669461


Do you know of a great paper that uses Quinidine from Tocris? Please let us know.

Reviews for Quinidine

There are currently no reviews for this product. Be the first to review Quinidine and earn rewards!

Have you used Quinidine?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


New Product Guide

New Product Guide (Spring/Summer 2018)

Our new product guide highlights over 200 new products added to the Tocris Bioscience range during the second half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Aptamers
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells