You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Biological Activity for Quinidine
Quinidine is a class IA antiarrythmic; reduces both Na+ and K+ channel currents, including INa, IKr and IKs. Prolongs QT and induces torsade de pointes (TdP).
Technical Data for Quinidine
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Quinidine
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Quinidine
The following data is based on the product molecular weight 324.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.08 mL||15.41 mL||30.82 mL|
|5 mM||0.62 mL||3.08 mL||6.16 mL|
|10 mM||0.31 mL||1.54 mL||3.08 mL|
|50 mM||0.06 mL||0.31 mL||0.62 mL|
References for Quinidine
References are publications that support the biological activity of the product.
Caballero et al (2003) Effects of fleca. and q.dine on Kv4.2 currents: voltage dependence and role of S6 valines. Br.J.Pharmacol. 138 1475 PMID: 12721103
Borggrefe et al (2005) Short QT syndrome genotype-genotype correlations. J.Electrocardiol. 38 75 PMID: 16226079
Wu et al (2008) Role of late sodium current in modulating the proarrhythmic and antiarrhythmic effects of q.dine Heart Rhythm. 5 1726 PMID: 19084812
If you know of a relevant reference for Quinidine, please let us know.
View Related Products by Target
Keywords: Quinidine, Quinidine supplier, sodium, Na+, potassium, K+, channel, blockers, IKr, IKs, IK1, IK-ATP, Ito, INa, antiarrhythmic, class, 1A, torsade, de, pointes, prolongs, qt, interval, Other, Channel, Modulators, 4108, Tocris Bioscience
5 Citations for Quinidine
Citations are publications that use Tocris products. Selected citations for Quinidine include:
Kim et al (2016) Targeting cancer metabolism by simultaneously disrupting parallel nutrient access pathways. J Clin Invest 126 4088 PMID: 27669461
He et al (2017) Downregulation of miR-7116-5p in microglia by MPP+ sensitizes TNF-α production to induce dopaminergic neuron damage. Glia 65 1251 PMID: 28543680
Jean-Didier et al (2017) GABAB receptors in neocortical and hippocampal pyramidal neurons are coupled to different potassium channels. Eur J Neurosci 46 2859-2866 PMID: 29131436
Ting-Xin et al (2021) Global feather orientations changed by electric current. iScience 24 102671 PMID: 34179734
Richard et al (2013) Electrophysiological characterization and computational models of HVC neurons in the zebra finch. J Neurophysiol 110 1227-45 PMID: 23719205
Do you know of a great paper that uses Quinidine from Tocris? Please let us know.
Reviews for Quinidine
Average Rating: 5 (Based on 2 Reviews.)
Have you used Quinidine?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Excellent for blocking organic cation transport at 50 uM in rat aorta. However also acts as non-competitive antagonist of alpha-1 adrenoceptors. This is evidenced by the fact it can block vasoconstrictor responses induced by the alpha-1 adrenoceptor agonist phenylephrine in a non-competitive manner.