Discontinued Product

PZ-II-029 (Cat. No. 6192) has been withdrawn from sale for commercial reasons.
Description: α6β3γ2-selective GABAA positive allosteric modulator
Alternative Names: Compound 6
Chemical Name: 2,5-Dihydro-7-methoxy-2-(4-methoxyphenyl)-3H-pyrazolo[4,3-c]quinolin-3-one
Purity: ≥98% (HPLC)
Literature (2)

Biological Activity for PZ-II-029

PZ-II-029 is a GABAA positive allosteric modulator. Selectively binds with high affinity to α6β3γ2 subunit-containing channels. Inhibits central and peripheral trigeminal responses in a rat migraine model.

Technical Data for PZ-II-029

M. Wt 321.33
Formula C18H15N3O3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 164025-44-9
PubChem ID 10426200
Smiles O=C1C2=CNC3=CC(OC)=CC=C3C2=NN1C(C=C4)=CC=C4OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for PZ-II-029

References are publications that support the biological activity of the product.

Varagic et al (2013) Subtype selectivity of α+β- site ligands of GABAA receptors: identification of the first highly specific positive modulators at α6β2/3γ2 receptors. Br.J.Pharmacol. 169 384 PMID: 23472935

Fan et al (2018) The α6 subunit-containing GABAA receptor: A novel drug target for inhibition of trigeminal activation. Neuropharmacology. 140 1 PMID: 30016665

View Related Products by Target

View Related Products by Product Action

View all GABAA Receptor Modulators

Keywords: PZ-II-029, PZ-II-029 supplier, GABAA, modulators, modulates, selective, high, affinity, alpha6beta3gamma2, a6b3g2, α6β3γ2, migraine, Compound, 6, Receptors, 6192, Tocris Bioscience

Citations for PZ-II-029

Citations are publications that use Tocris products.

Currently there are no citations for PZ-II-029.

Reviews for PZ-II-029

There are currently no reviews for this product. Be the first to review PZ-II-029 and earn rewards!

Have you used PZ-II-029?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

GABA Receptors Scientific Review

GABA Receptors Scientific Review

Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.

Addiction Poster

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.