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Cat.No. 6192 - PZ-II-029 | C18H15N3O3 | CAS No. 164025-44-9
Description: α6β3γ2-selective GABAA positive allosteric modulator
Alternative Names: Compound 6
Chemical Name: 2,5-Dihydro-7-methoxy-2-(4-methoxyphenyl)-3H-pyrazolo[4,3-c]quinolin-3-one
Purity: ≥98% (HPLC)
Literature (7)

Biological Activity

GABAA positive allosteric modulator. Selectively binds with high affinity to α6β3γ2 subunit-containing channels. Inhibits central and peripheral trigeminal responses in a rat migraine model.

Technical Data

M. Wt 321.33
Formula C18H15N3O3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 164025-44-9
PubChem ID 10426200
Smiles O=C1C2=CNC3=CC(OC)=CC=C3C2=NN1C(C=C4)=CC=C4OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 32.13 100

Preparing Stock Solutions

The following data is based on the product molecular weight 321.33. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.11 mL 15.56 mL 31.12 mL
5 mM 0.62 mL 3.11 mL 6.22 mL
10 mM 0.31 mL 1.56 mL 3.11 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

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References are publications that support the biological activity of the product.

Varagic et al (2013) Subtype selectivity of α+β- site ligands of GABAA receptors: identification of the first highly specific positive modulators at α6β2/3γ2 receptors. Br.J.Pharmacol. 169 384 PMID: 23472935

Fan et al (2018) The α6 subunit-containing GABAA receptor: A novel drug target for inhibition of trigeminal activation. Neuropharmacology. 140 1 PMID: 30016665

If you know of a relevant reference for PZ-II-029, please let us know.

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Keywords: PZ-II-029, PZ-II-029 supplier, GABAA, modulators, modulates, selective, high, affinity, alpha6beta3gamma2, a6b3g2, α6β3γ2, migraine, Compound, 6, Receptors, 6192, Tocris Bioscience

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