PZ-II-029

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Cat.No. 6192 - PZ-II-029 | C18H15N3O3 | CAS No. 164025-44-9
Description: α6β3γ2-selective GABAA channel modulator
Chemical Name: 2,5-Dihydro-7-methoxy-2-(4-methoxyphenyl)-3H-pyrazolo[4,3-c]quinolin-3-one
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

GABAA channel modulator. Binds with high affinity to α6β3γ2 subunit-containing channels.

Technical Data

M. Wt 321.33
Formula C18H15N3O3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 164025-44-9
PubChem ID 10426200
InChI Key CGOOCGJMECBDCB-UHFFFAOYSA-N
Smiles O=C1C2=CNC3=CC(OC)=CC=C3C2=NN1C(C=C4)=CC=C4OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 32.13 100

Preparing Stock Solutions

The following data is based on the product molecular weight 321.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.11 mL 15.56 mL 31.12 mL
5 mM 0.62 mL 3.11 mL 6.22 mL
10 mM 0.31 mL 1.56 mL 3.11 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Varagic et al (2013) Subtype selectivity of α+β- site ligands of GABAA receptors: identification of the first highly specific positive modulators at α6β2/3γ2 receptors. Br.J.Pharmacol. 169 384 PMID: 23472935


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Keywords: PZ-II-029, PZ-II-029 supplier, GABAA, modulators, modulates, selective, high, affinity, alpha6beta3gamma2, a6b3g2, α6β3γ2, Receptors, 6192, Tocris Bioscience

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