Pyrrolidinedithiocarbamate ammonium

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Cat.No. 0727 - Pyrrolidinedithiocarbamate ammonium | C5H12N2S2 | CAS No. 5108-96-3
Description: Inhibits NF-κB, prevents increase in NOS mRNA
Alternative Names: PDTC
Citations (6)

Biological Activity

This inhibitor of nuclear factor κB (NF-κB) prevents the increase in NO-synthase mRNA by interleukin-1, without affecting the formation of NO-synthase mRNA produced by cAMP.

Technical Data

M. Wt 164.28
Formula C5H12N2S2
Storage Store at RT
CAS Number 5108-96-3
PubChem ID 73343
Smiles [NH4+].[S-]C(N1CCCC1)=S

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 16.43 100

Preparing Stock Solutions

The following data is based on the product molecular weight 164.28. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 6.09 mL 30.44 mL 60.87 mL
5 mM 1.22 mL 6.09 mL 12.17 mL
10 mM 0.61 mL 3.04 mL 6.09 mL
50 mM 0.12 mL 0.61 mL 1.22 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Bessho et al (1994) Pyrrolidine dithiocarbamate, a potent inhibitor of nuclear factor κB (NF-κB) activation, prevents apoptosis in human promyelocytic leukemia HL-60 cells and thymocytes. Biochem.Pharmacol. 48 1883 PMID: 7986199

Eberhardt et al (1994) Pyrrolidine dithiocarbamate differentially affects 1β- and cAMP-induced NO-synthase expression in rat renal mesangial cells. Biochem.Biophys.Res.Commun. 200 163 PMID: 7513157

Schini-Kerth (1994) Pyrrolidine dithiocarbamate selectively prevents the expression of the inducible nitric oxide synthase in the rat aorta. Eur.J.Pharmacol. 265 83 PMID: 7533726

If you know of a relevant reference for Pyrrolidinedithiocarbamate ammonium, please let us know.

View Related Products by Product Action

View all NF-κB and IκB Inhibitors

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6 Citations for Pyrrolidinedithiocarbamate ammonium

Citations are publications that use Tocris products. Selected citations for Pyrrolidinedithiocarbamate ammonium include:

Nadeem (2017) IL-17A causes depression-like symptoms via NFκB and p38MAPK signaling pathways in mice: Implications for psoriasis associated depression. Cytokine 97 14 PMID: 28570931

Ishizuka et al (2016) PAFR activation of NF-& #954;B p65 or p105 precursor dictates pro-and anti-inflammatory responses during TLR activation in murine macrophages Scientific Reports 6 32092 PMID: 27554194

Wang et al (2015) Downregulation of toll-like receptor 4 induces suppressive effects on hepatitis B virus-related hepatocellular carcinoma via ERK1/2 signaling. Sci Rep 15 821 PMID: 26514586

Lin et al (2015) Kallistatin protects against sepsis-related acute lung injury via inhibiting inflammation and apoptosis. J Neurosci 5 12463 PMID: 26198099

Muxel et al (2013) NF-κB drives the synthesis of melatonin in RAW 264.7 macrophages by inducing the transcription of the arylalkylamine-N-acetyltransferase (AA-NAT) gene. BMC Cancer 7 e52010 PMID: 23284853

Birmingham et al (2009) Novel mechanism for obesity-induced colon cancer progression. Carcinogenesis 30 690 PMID: 19221001

Do you know of a great paper that uses Pyrrolidinedithiocarbamate ammonium from Tocris? If so please let us know.

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Pathways for Pyrrolidinedithiocarbamate ammonium


NF-κB Signaling Pathway

NF-κB signaling plays an important role in inflammation, the innate and adaptive immune response and stress. Dysregulated signaling can occur in inflammatory and autoimmune diseases.