Pyrrolidinedithiocarbamate ammonium

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Cat.No. 0727 - Pyrrolidinedithiocarbamate ammonium | C5H12N2S2 | CAS No. 5108-96-3
Description: Inhibits NF-κB, prevents increase in NOS mRNA
Alternative Names: PDTC
Citations (8)
Reviews (1)
Literature (3)
Pathways (1)

Biological Activity for Pyrrolidinedithiocarbamate ammonium

This inhibitor of nuclear factor κB (NF-κB) prevents the increase in NO-synthase mRNA by interleukin-1, without affecting the formation of NO-synthase mRNA produced by cAMP.

Technical Data for Pyrrolidinedithiocarbamate ammonium

M. Wt 164.28
Formula C5H12N2S2
Storage Store at RT
CAS Number 5108-96-3
PubChem ID 73343
Smiles [NH4+].[S-]C(N1CCCC1)=S

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Pyrrolidinedithiocarbamate ammonium

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 16.43 100

Preparing Stock Solutions for Pyrrolidinedithiocarbamate ammonium

The following data is based on the product molecular weight 164.28. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 6.09 mL 30.44 mL 60.87 mL
5 mM 1.22 mL 6.09 mL 12.17 mL
10 mM 0.61 mL 3.04 mL 6.09 mL
50 mM 0.12 mL 0.61 mL 1.22 mL

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Product Datasheets for Pyrrolidinedithiocarbamate ammonium

References for Pyrrolidinedithiocarbamate ammonium

References are publications that support the biological activity of the product.

Bessho et al (1994) Pyrrolidine dithiocarbamate, a potent inhibitor of nuclear factor κB (NF-κB) activation, prevents apoptosis in human promyelocytic leukemia HL-60 cells and thymocytes. Biochem.Pharmacol. 48 1883 PMID: 7986199

Eberhardt et al (1994) Pyrrolidine dithiocarbamate differentially affects 1β- and cAMP-induced NO-synthase expression in rat renal mesangial cells. Biochem.Biophys.Res.Commun. 200 163 PMID: 7513157

Schini-Kerth (1994) Pyrrolidine dithiocarbamate selectively prevents the expression of the inducible nitric oxide synthase in the rat aorta. Eur.J.Pharmacol. 265 83 PMID: 7533726

If you know of a relevant reference for Pyrrolidinedithiocarbamate ammonium, please let us know.

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View all NF-κB and IκB Inhibitors

Keywords: Pyrrolidinedithiocarbamate ammonium, Pyrrolidinedithiocarbamate ammonium supplier, inhibitors, inhibits, NF-κB, NF-kappaB, NF-kB, NOS, mRNA, NFκB, NFkappaB, Nitric, Oxide, Signaling, Signalling, IκB, IkappaB, Nuclear, Factor, Kappa, B, Transcription, Factors, PDTC, Other, NF-kB/IkB, 0727, Tocris Bioscience

8 Citations for Pyrrolidinedithiocarbamate ammonium

Citations are publications that use Tocris products. Selected citations for Pyrrolidinedithiocarbamate ammonium include:

Wang et al (2015) Downregulation of toll-like receptor 4 induces suppressive effects on hepatitis B virus-related hepatocellular carcinoma via ERK1/2 signaling. Sci Rep 15 821 PMID: 26514586

Lin et al (2015) Kallistatin protects against sepsis-related acute lung injury via inhibiting inflammation and apoptosis. J Neurosci 5 12463 PMID: 26198099

Birmingham et al (2009) Novel mechanism for obesity-induced colon cancer progression. Carcinogenesis 30 690 PMID: 19221001

Ishizuka et al (2016) PAFR activation of NF-& #954;B p65 or p105 precursor dictates pro-and anti-inflammatory responses during TLR activation in murine macrophages Scientific Reports 6 32092 PMID: 27554194

Do you know of a great paper that uses Pyrrolidinedithiocarbamate ammonium from Tocris? Please let us know.

Reviews for Pyrrolidinedithiocarbamate ammonium

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PDTC inhibits HOCl-LDL-induced CaMKII oxidation.
By Chintan Koyani on 10/22/2018
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: Cardiomyocytes

HL-1 cardiomyocytes were pre-treated with Pyrrolidinedithiocarbamate (PDTC, 1 mM), Tempol (1 mM) or N-Acetylcysteine (NAC, 1 mM) for 30 min and stimulated with HOCl-LDL (200 µg/ml) for 2 h to follow CaMKII oxidation using Western blot.

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Literature in this Area

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Pathways for Pyrrolidinedithiocarbamate ammonium

NF-κB Signaling Pathway

NF-κB Signaling Pathway

NF-κB signaling plays an important role in inflammation, the innate and adaptive immune response and stress. Dysregulated signaling can occur in inflammatory and autoimmune diseases.