Pyrrolidinedithiocarbamate ammonium

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Cat.No. 0727 - Pyrrolidinedithiocarbamate ammonium | C5H12N2S2 | CAS No. 5108-96-3
Description: Inhibits NF-κB, prevents increase in NOS mRNA
Alternative Names: PDTC
Datasheet
Citations (8)
Reviews (1)
Literature (3)
Pathways (1)

Biological Activity

This inhibitor of nuclear factor κB (NF-κB) prevents the increase in NO-synthase mRNA by interleukin-1, without affecting the formation of NO-synthase mRNA produced by cAMP.

Technical Data

M. Wt 164.28
Formula C5H12N2S2
Storage Store at RT
CAS Number 5108-96-3
PubChem ID 73343
InChI Key MDDIUTVUBYEEEM-UHFFFAOYSA-N
Smiles [NH4+].[S-]C(N1CCCC1)=S

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 16.43 100

Preparing Stock Solutions

The following data is based on the product molecular weight 164.28. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 6.09 mL 30.44 mL 60.87 mL
5 mM 1.22 mL 6.09 mL 12.17 mL
10 mM 0.61 mL 3.04 mL 6.09 mL
50 mM 0.12 mL 0.61 mL 1.22 mL

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References

References are publications that support the biological activity of the product.

Bessho et al (1994) Pyrrolidine dithiocarbamate, a potent inhibitor of nuclear factor κB (NF-κB) activation, prevents apoptosis in human promyelocytic leukemia HL-60 cells and thymocytes. Biochem.Pharmacol. 48 1883 PMID: 7986199

Eberhardt et al (1994) Pyrrolidine dithiocarbamate differentially affects 1β- and cAMP-induced NO-synthase expression in rat renal mesangial cells. Biochem.Biophys.Res.Commun. 200 163 PMID: 7513157

Schini-Kerth (1994) Pyrrolidine dithiocarbamate selectively prevents the expression of the inducible nitric oxide synthase in the rat aorta. Eur.J.Pharmacol. 265 83 PMID: 7533726


If you know of a relevant reference for Pyrrolidinedithiocarbamate ammonium, please let us know.

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View all NF-κB and IκB Inhibitors

Keywords: Pyrrolidinedithiocarbamate ammonium, Pyrrolidinedithiocarbamate ammonium supplier, inhibitors, inhibits, NF-κB, NF-kappaB, NF-kB, NOS, mRNA, NFκB, NFkappaB, Nitric, Oxide, Signaling, Signalling, IκB, IkappaB, Nuclear, Factor, Kappa, B, Transcription, Factors, PDTC, Other, NF-kB/IkB, 0727, Tocris Bioscience

8 Citations for Pyrrolidinedithiocarbamate ammonium

Citations are publications that use Tocris products. Selected citations for Pyrrolidinedithiocarbamate ammonium include:

Birmingham et al (2009) Novel mechanism for obesity-induced colon cancer progression. Carcinogenesis 30 690 PMID: 19221001

Li et al (2017) Follicular Stimulating Hormone Accelerates Atherogenesis by Increasing Endothelial VCAM-1 Expression. Theranostics 7 4671 PMID: 29187895

Ishizuka et al (2016) PAFR activation of NF-& #954;B p65 or p105 precursor dictates pro-and anti-inflammatory responses during TLR activation in murine macrophages Scientific Reports 6 32092 PMID: 27554194

Muxel et al (2013) NF-κB drives the synthesis of melatonin in RAW 264.7 macrophages by inducing the transcription of the arylalkylamine-N-acetyltransferase (AA-NAT) gene. BMC Cancer 7 e52010 PMID: 23284853


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Reviews for Pyrrolidinedithiocarbamate ammonium

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PDTC inhibits HOCl-LDL-induced CaMKII oxidation.
By Chintan Koyani on 10/22/2018
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: Cardiomyocytes

HL-1 cardiomyocytes were pre-treated with Pyrrolidinedithiocarbamate (PDTC, 1 mM), Tempol (1 mM) or N-Acetylcysteine (NAC, 1 mM) for 30 min and stimulated with HOCl-LDL (200 µg/ml) for 2 h to follow CaMKII oxidation using Western blot.

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Literature in this Area

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Pathways for Pyrrolidinedithiocarbamate ammonium

NF-κB

NF-κB Signaling Pathway

NF-κB signaling plays an important role in inflammation, the innate and adaptive immune response and stress. Dysregulated signaling can occur in inflammatory and autoimmune diseases.