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ProTx III

Cat. No. 5792 Submit a Review Datasheet / COA / SDS
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Cat.No. 5792 - ProTx III | Asp-Cys-Leu-Lys-Phe-Gly-Trp-Lys-Cys-Asn-Pro-Arg-Asn-Asp-Lys-Cys-Cys-Ser-Gly-Leu-Lys-Cys-Gly-Ser-Asn-His-Asn-Trp-Cys-Lys-Leu-His-Ile-NH2
Description: Potent Nav1.7 blocker; analgesic
Datasheet
Citations
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Literature
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Potent Nav1.7 blocker (IC50 = 2.5 nM). Also inhibits Nav1.1, Nav1.2, Nav1.3 and Nav1.6 in the nanomolar range. Exhibits no effects on Cav channels or nAChR at 5 μM. Demonstrates analgesic activity in vivo; antagonizes effects of scorpion-venom toxin OD1 at Nav1.7.

Technical Data

M. Wt 3802.41
Formula C162H246N52O43S6
Sequence DCLKFGWKCNPRNDKCCSGLKCGSNHNWCKLHI

(Modifications: Disulfide bridge: 2-17, 9-22, 16-29, Ile-33 = C-terminal amide)
Storage Store at -20°C
PubChem ID 121513895
InChI Key CLSMEZFRATUESA-ZYYCRPBWSA-N
Smiles [H]N[C@@H](CC(O)=O)C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CC4=CNC5=C4C=CC=C5)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC4=CNC=N4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC4=CNC5=C4C=CC=C5)NC(=O)CNC(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N3)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H]([C@@H](C)CC)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 1 mg/ml in water

References

References are publications that support the biological activity of the product.

Cardoso et al (2015) Identification and characterization of ProTx-III [μ-TRTX-Tp1a], a new voltage-gated sodium channel inhibitor from venom of the tarantula thrixopelma pruriens. Mol.Pharmacol. 88 291 PMID: 25979003

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Keywords: ProTx III, ProTx III supplier, Potent, Nav1.7, blockers, inhibitors, inhibits, Nav1.1,, Nav1.2,, Nav1.3, Nav1.6, analgesics, voltage, gated, sodium, channels, venoms, Voltage-gated, Sodium, Channels, 5792, Tocris Bioscience

Citations for ProTx III

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Literature in this Area

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