ProTx III

Cat. No. 5792 Submit a Review Datasheet / COA / SDS

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Cat.No. 5792 - ProTx III | Asp-Cys-Leu-Lys-Phe-Gly-Trp-Lys-Cys-Asn-Pro-Arg-Asn-Asp-Lys-Cys-Cys-Ser-Gly-Leu-Lys-Cys-Gly-Ser-Asn-His-Asn-Trp-Cys-Lys-Leu-His-Ile-NH2

Description: Potent Na_v1.7 blocker; analgesic

Datasheet

Citations

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Literature

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Potent Na_v1.7 blocker (IC₅₀ = 2.5 nM). Also inhibits Na_v1.1, Na_v1.2, Na_v1.3 and Na_v1.6 in the nanomolar range. Exhibits no effects on Ca_v channels or nAChR at 5 μM. Demonstrates analgesic activity in vivo; antagonizes effects of scorpion-venom toxin OD1 at Na_v1.7.

Technical Data

M. Wt	3802.41
Formula	C₁₆₂H₂₄₆N₅₂O₄₃S₆
Sequence	DCLKFGWKCNPRNDKCCSGLKCGSNHNWCKLHI (Modifications: Disulfide bridge: 2-17, 9-22, 16-29, Ile-33 = C-terminal amide)
Storage	Store at -20°C
PubChem ID	121513895
InChI Key	CLSMEZFRATUESA-ZYYCRPBWSA-N
Smiles	[H]N[C@@H](CC(O)=O)C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CC4=CNC5=C4C=CC=C5)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC4=CNC=N4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC4=CNC5=C4C=CC=C5)NC(=O)CNC(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N3)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H]([C@@H](C)CC)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility

Soluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 3802.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	0.26 mL	1.31 mL	2.63 mL
5 mM	0.05 mL	0.26 mL	0.53 mL
10 mM	0.03 mL	0.13 mL	0.26 mL
50 mM	0.01 mL	0.03 mL	0.05 mL

Molarity Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the biological activity of the product.

Cardoso et al (2015) Identification and characterization of ProTx-III [μ-TRTX-Tp1a], a new voltage-gated sodium channel inhibitor from venom of the tarantula thrixopelma pruriens. Mol.Pharmacol. 88 291 PMID: 25979003

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Keywords: ProTx III, ProTx III supplier, Potent, Nav1.7, blockers, inhibitors, inhibits, Nav1.1,, Nav1.2,, Nav1.3, Nav1.6, analgesics, voltage, gated, sodium, channels, venoms, Voltage-gated, Sodium, Channels, 5792, Tocris Bioscience

Citations for ProTx III

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Literature in this Area

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