Propranolol hydrochloride

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Cat.No. 0624 - Propranolol hydrochloride | C16H21NO2.HCl | CAS No. 318-98-9
Description: β antagonist
Chemical Name: (RS)-1-[(1-Methylethyl)amino]-3-(1-naphthalenyloxy)-2-propanol hydrochloride
Datasheet
Citations (12)
Reviews (1)
Literature (4)

Biological Activity

β-adrenergic antagonist.

R-enantiomer, S-enantiomer and Glycol Metabolite also available.

Technical Data

M. Wt 295.81
Formula C16H21NO2.HCl
Storage Store at RT
CAS Number 318-98-9
PubChem ID 62882
InChI Key ZMRUPTIKESYGQW-UHFFFAOYSA-N
Smiles Cl.CC(C)NCC(O)COC1=C2C=CC=CC2=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 29.58 100

Preparing Stock Solutions

The following data is based on the product molecular weight 295.81. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.38 mL 16.9 mL 33.81 mL
5 mM 0.68 mL 3.38 mL 6.76 mL
10 mM 0.34 mL 1.69 mL 3.38 mL
50 mM 0.07 mL 0.34 mL 0.68 mL

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References

References are publications that support the biological activity of the product.

Litwin et al (1999) Effects of propra. treatment on left ventricular function and intracellular calcium regulation in rats with postinfarction heart failure. Br.J.Pharmacol. 127 1671 PMID: 10455325

Xie et al (1998) The inhibitory effect of propra. on ATP-sensitive potassium channels in neonatal rat heart. Br.J.Pharmacol. 123 599 PMID: 9517376

Merck Index 12 8025


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Keywords: Propranolol hydrochloride, Propranolol hydrochloride supplier, β-adrenoceptor, beta-adrenoceptors, b-adrenoceptors, b-adrenergic, antagonists, β-adrenergic, beta-adrenergic, Receptors, Non-Selective, β-blockers, beta-blockers, 3506-09-0, Non-selective, Adrenergic, Beta, 0624, Tocris Bioscience

12 Citations for Propranolol hydrochloride

Citations are publications that use Tocris products. Selected citations for Propranolol hydrochloride include:

Kilpatrick et al (2019) Complex Formation between VEGFR2 and the β2-Adrenoceptor. Cell Chem Biol PMID: 30956148

Patsouris et al (2015) Burn Induces Browning of the Subcutaneous White Adipose Tissue in Mice and Humans. Cereb Cortex 13 1538 PMID: 26586436

Hansen and Manahan-Vaughan (2015) Locus Coeruleus Stimulation Facilitates Long-Term Depression in the Dentate Gyrus That Requires Activation of β-Adrenergic Receptors. Mol Cancer 25 1889 PMID: 24464942

McKeithan et al (2017) An Automated Platform for Assessment of Congenital and Drug-Induced Arrhythmia with hiPSC-Derived Cardiomyocytes. Front Physiol 8 766 PMID: 29075196


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Reviews for Propranolol hydrochloride

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Propranolol hydrochroride treated postnatal mice decreased PI3K activity in heart.
By YANCHUN XU on 01/05/2018
Assay Type: In Vivo
Species: Mouse
Cell Line/Tissue: heart

We used Propranolol hydrochroride (cat#0624) to treat postnatal mice to investigate the PI3K activity change

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Literature in this Area

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*Please note that Tocris will only send literature to established scientific business / institute addresses.


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