(S)-(-)-Propranolol hydrochloride

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Cat.No. 0834 - (S)-(-)-Propranolol hydrochloride | C16H21NO2.HCl | CAS No. 4199-10-4
Description: β antagonist. More active enantiomer of propranolol (Cat. No. 0624)
Chemical Name: (S)-(-)-1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy)-2-propanol hydrochloride
Datasheet
Citations (1)
Literature

Biological Activity

More active enantiomer of the β-adrenoceptor antagonist propranolol (Cat. No. 0624). (R)-(+)-Propranolol hydrochloride (Cat. No. 0835) also available.

Technical Data

M. Wt 295.81
Formula C16H21NO2.HCl
Storage Store at RT
CAS Number 4199-10-4
PubChem ID 165193
InChI Key ZMRUPTIKESYGQW-UQKRIMTDSA-N
Smiles CC(C)NC[C@]([H])(O)COC2=CC=CC1=CC=CC=C12.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in water

Preparing Stock Solutions

The following data is based on the product molecular weight 295.81. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.38 mL 16.9 mL 33.81 mL
5 mM 0.68 mL 3.38 mL 6.76 mL
10 mM 0.34 mL 1.69 mL 3.38 mL
50 mM 0.07 mL 0.34 mL 0.68 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Barrett et al (1968) The biological properties of the optical isomers of propranolol and their effects on cardiac arrhythmias. Br.J.Pharmacol. 34 43 PMID: 19108278

Bond et al (1967) Metabolism of propranolol (Inderal) a potent, specific β-adrenergic receptor blocking agent. Nature 213 721 PMID: 6031788


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1 Citation for (S)-(-)-Propranolol hydrochloride

Citations are publications that use Tocris products. Selected citations for (S)-(-)-Propranolol hydrochloride include:

Kaya et al (2009) Coupling of β2-adrenoceptors to XLαs and Gαs: a new insight into ligand-induced G protein activation. Br J Pharmacol 329 350 PMID: 19144685


Do you know of a great paper that uses (S)-(-)-Propranolol hydrochloride from Tocris? If so please let us know.

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Pathways for (S)-(-)-Propranolol hydrochloride

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