Pristimerin

Pricing Availability   Qty
Cat.No. 3731 - Pristimerin | C30H40O4 | CAS No. 1258-84-0
Description: Potent, reversible MAGL inhibitor
Chemical Name: (9β,13α,14β,20α)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid methyl ester
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent and reversible inhibitor of monoacylglycerol lipase (MGL) (IC50 = 93 nM). Also suppresses NF-κB activation via inhibition of proteasome chymotrypsin-like activity and IKKαβ. Displays antitumor, anti-inflammatory and antimicrobial activities.

Technical Data

M. Wt 464.64
Formula C30H40O4
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 1258-84-0
PubChem ID 159516
InChI Key JFACETXYABVHFD-WXPPGMDDSA-N
Smiles O=C2C(O)=C(C)C1=CC=C([C@](CC[C@]5(C)[C@]([H])4C[C@](C)([C@](OC)=O)CC5)(C)[C@@]4(C)CC3)[C@]3(C)C1=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 11.62 25
ethanol 4.65 10

Preparing Stock Solutions

The following data is based on the product molecular weight 464.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 8.61 mL 43.04 mL 86.09 mL
1.25 mM 1.72 mL 8.61 mL 17.22 mL
2.5 mM 0.86 mL 4.3 mL 8.61 mL
12.5 mM 0.17 mL 0.86 mL 1.72 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References

References are publications that support the biological activity of the product.

Byun et al (2009) Reactive oxygen species-dependent activation of Bax and Poly(ADP)-ribose) polymerase-1 is requried for mitochondrial cell death induced by triterpenoid Pristimerin in human cervical cancer cells. Mol.Pharmacol. 76 734 PMID: 19574249

Tiedemann et al (2009) Identification of a potent natural triterpenoid inhibitor of proteosome chymotrypsin-like activity and NF-κB with antimyeloma activity in vitro and in vivo. Blood 113 4027 PMID: 19096011

King et al (2009) Discovery of potent and reversible monoacylglycerol lipase inhibitors. Chem.Biol. 16 1045 PMID: 19875078


If you know of a relevant reference for Pristimerin, please let us know.

View Related Products by Product Action

View all Monoacylglycerol Lipase Inhibitors

Keywords: Pristimerin, Pristimerin supplier, MAGL, MGL, monoacylglycerol, lipase, inhibitors, lipases, NF-kB, NF-kappaB, NF-κB, inhibits, suppresses, activation, nuclear, factor, kappa, B, transcription, factors, NF-kB/IkB, 3731, Tocris Bioscience

Citations for Pristimerin

Citations are publications that use Tocris products.

Currently there are no citations for Pristimerin. Do you know of a great paper that uses Pristimerin from Tocris? Please let us know.

Reviews for Pristimerin

There are currently no reviews for this product. Be the first to review Pristimerin and earn rewards!

Have you used Pristimerin?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Pain

Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
Cannabinoid Receptor Ligands

Cannabinoid Receptor Ligands Scientific Review

Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.

Addiction

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.

Pain

Pain Poster

Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.