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Biological Activity for Pristimerin
Pristimerin is a potent and reversible inhibitor of monoacylglycerol lipase (MGL) (IC50 = 93 nM). Also suppresses NF-κB activation via inhibition of proteasome chymotrypsin-like activity and IKKαβ. Displays antitumor, anti-inflammatory and antimicrobial activities.
Technical Data for Pristimerin
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Pristimerin
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Pristimerin
The following data is based on the product molecular weight 464.64. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.25 mM||8.61 mL||43.04 mL||86.09 mL|
|1.25 mM||1.72 mL||8.61 mL||17.22 mL|
|2.5 mM||0.86 mL||4.3 mL||8.61 mL|
|12.5 mM||0.17 mL||0.86 mL||1.72 mL|
References for Pristimerin
References are publications that support the biological activity of the product.
Byun et al (2009) Reactive oxygen species-dependent activation of Bax and Poly(ADP)-ribose) polymerase-1 is requried for mitochondrial cell death induced by triterpenoid Pristimerin in human cervical cancer cells. Mol.Pharmacol. 76 734 PMID: 19574249
Tiedemann et al (2009) Identification of a potent natural triterpenoid inhibitor of proteosome chymotrypsin-like activity and NF-κB with antimyeloma activity in vitro and in vivo. Blood 113 4027 PMID: 19096011
King et al (2009) Discovery of potent and reversible monoacylglycerol lipase inhibitors. Chem.Biol. 16 1045 PMID: 19875078
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Keywords: Pristimerin, Pristimerin supplier, MAGL, MGL, monoacylglycerol, lipase, inhibitors, lipases, NF-kB, NF-kappaB, NF-κB, inhibits, suppresses, activation, nuclear, factor, kappa, B, transcription, factors, NF-kB/IkB, 3731, Tocris Bioscience
1 Citation for Pristimerin
Citations are publications that use Tocris products. Selected citations for Pristimerin include:
El-Agamy et al (2018) Pristimerin as a Novel Hepatoprotective Agent Against Experimental Autoimmune Hepatitis. Front Pharmacol 9 292 PMID: 29643811
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.