Pregnanolone

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Cat.No. 3652 - Pregnanolone | C21H34O2 | CAS No. 128-20-1
Description: Postitive allosteric modulator of GABAA receptors
Chemical Name: (3α,5β)-3-Hydroxy-pregnan-20-one
Datasheet
Citations
Reviews
Literature

Biological Activity

GABAA receptor positive allosteric modulator. Neuroactive steroid.

Compound Libraries

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Technical Data

M. Wt 318.49
Formula C21H34O2
Storage Store at RT
CAS Number 128-20-1
PubChem ID 31402
InChI Key AURFZBICLPNKBZ-YZRLXODZSA-N
Smiles C[C@@]12[C@@](CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@@H]4C(C)=O)([H])C[C@H](O)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 31.85 100
ethanol 31.85 100

Preparing Stock Solutions

The following data is based on the product molecular weight 318.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.14 mL 15.7 mL 31.4 mL
5 mM 0.63 mL 3.14 mL 6.28 mL
10 mM 0.31 mL 1.57 mL 3.14 mL
50 mM 0.06 mL 0.31 mL 0.63 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Harrison et al (1987) Structure-activity relationships for steroid interaction with the γ-aminobutyric acidA receptor complex. J.Pharmacol.Exp.Ther. 241 346 PMID: 3033209

Morris et al (1999) Differential modulation of the γ-aminobutyric acid type C receptor by neuroactive steroids. Mol.Pharmacol. 56 752 PMID: 10496958


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Citations for Pregnanolone

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*Please note that Tocris will only send literature to established scientific business / institute addresses.


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