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Description: Postitive allosteric modulator of GABAA receptors
Chemical Name: (3α,5β)-3-Hydroxy-pregnan-20-one
Literature (2)

Biological Activity for Pregnanolone

Pregnanolone is a GABAA receptor positive allosteric modulator. Neuroactive steroid.

Technical Data for Pregnanolone

M. Wt 318.49
Formula C21H34O2
Storage Store at RT
CAS Number 128-20-1
PubChem ID 31402
Smiles C[C@@]12[C@@](CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@@H]4C(C)=O)([H])C[C@H](O)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Pregnanolone

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 31.85 100
ethanol 31.85 100

Preparing Stock Solutions for Pregnanolone

The following data is based on the product molecular weight 318.49. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.14 mL 15.7 mL 31.4 mL
5 mM 0.63 mL 3.14 mL 6.28 mL
10 mM 0.31 mL 1.57 mL 3.14 mL
50 mM 0.06 mL 0.31 mL 0.63 mL

Molarity Calculator

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Product Datasheets for Pregnanolone

Certificate of Analysis / Product Datasheet
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References for Pregnanolone

References are publications that support the biological activity of the product.

Harrison et al (1987) Structure-activity relationships for steroid interaction with the γ-aminobutyric acidA receptor complex. J.Pharmacol.Exp.Ther. 241 346 PMID: 3033209

Morris et al (1999) Differential modulation of the γ-aminobutyric acid type C receptor by neuroactive steroids. Mol.Pharmacol. 56 752 PMID: 10496958

If you know of a relevant reference for Pregnanolone, please let us know.

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Keywords: Pregnanolone, Pregnanolone supplier, GABAA, receptors, positive, allosteric, modulators, neuroactive, steroid, Receptors, 3652, Tocris Bioscience

Citations for Pregnanolone

Citations are publications that use Tocris products.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

GABA Receptors Scientific Review

GABA Receptors Scientific Review

Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.

Addiction Poster

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.