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Biological Activity for Pregnanolone
Pregnanolone is a GABAA receptor positive allosteric modulator. Neuroactive steroid.
Technical Data for Pregnanolone
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Pregnanolone
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Pregnanolone
The following data is based on the product molecular weight 318.49. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.14 mL||15.7 mL||31.4 mL|
|5 mM||0.63 mL||3.14 mL||6.28 mL|
|10 mM||0.31 mL||1.57 mL||3.14 mL|
|50 mM||0.06 mL||0.31 mL||0.63 mL|
References for Pregnanolone
References are publications that support the biological activity of the product.
Harrison et al (1987) Structure-activity relationships for steroid interaction with the γ-aminobutyric acidA receptor complex. J.Pharmacol.Exp.Ther. 241 346 PMID: 3033209
Morris et al (1999) Differential modulation of the γ-aminobutyric acid type C receptor by neuroactive steroids. Mol.Pharmacol. 56 752 PMID: 10496958
If you know of a relevant reference for Pregnanolone, please let us know.
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Keywords: Pregnanolone, Pregnanolone supplier, GABAA, receptors, positive, allosteric, modulators, neuroactive, steroid, Receptors, 3652, Tocris Bioscience
Citations for Pregnanolone
Citations are publications that use Tocris products.
Currently there are no citations for Pregnanolone. Do you know of a great paper that uses Pregnanolone from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
GABA Receptors Scientific Review
Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.
Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.