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Discontinued ProductPregabalin (Cat. No. 3775) has been withdrawn from sale for commercial reasons.
Anticonvulsant and antiepileptic; also used to treat neuropathic pain. Binds with high affinity and selectivity to the α2δ subunit of voltage-sensitive Ca2+ channels and modulates their activity. Displays anxiolytic-like activity in ethological and conflict models of anxiety. Analog of GABA (Cat. No. 0344).
Sold for research purposes under agreement from Pfizer Inc.
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The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Field et al (2001) Pregabalin may represent a novel class of anxiolytic agents with a broad spectrum of activity. Br.J.Pharmacol. 132 1 PMID: 11156553
Kumar et al (2010) Evidence that prega. reduces neuropathic pain by inhibiting the spinal release of glutamate. J.Neurochem. 113 552 PMID: 20132471
Arain (2009) Pregabalin in the management of partial epilepsy. Neuropsych.Dis.Treat. 5 407
Keywords: Pregabalin, Pregabalin supplier, anticonvulsants, neuropathic, pain, GABA, analgesics, anxiolytics, a2d, alpha2delta, α2δ, voltage-sensitive, calcium, channels, Ca2+, Non-selective, Cav, Channels, 3775, Tocris Bioscience
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Average Rating: 5 (Based on 1 Review.)
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Pregabalin was observed to understand its production of dose-dependent increase in the brain expression of L-glutamic acid decarboxylase (GAD), the enzyme responsible for synthesizing GABA, and hence how it may have some indirect GABAergic effects by increasing GABA levels in the brain.