Pregabalin

Discontinued Product

Pregabalin (Cat. No. 3775) has been withdrawn from sale for commercial reasons.
Cat.No. 3775 - Pregabalin | C8H17NO2 | CAS No. 148553-50-8
Description: Anticonvulsant; selectively binds the α2δ subunit of voltage-sensitive calcium channels
Chemical Name: (S)-3-(Aminomethyl)-5-methylhexanoic acid
Datasheet
Citations
Reviews (1)

Biological Activity

Anticonvulsant and antiepileptic; also used to treat neuropathic pain. Binds with high affinity and selectivity to the α2δ subunit of voltage-sensitive Ca2+ channels and modulates their activity. Displays anxiolytic-like activity in ethological and conflict models of anxiety. Analog of GABA (Cat. No. 0344).

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M. Wt 159.23
Formula C8H17NO2
Storage Store at RT
CAS Number 148553-50-8
PubChem ID 5486971
InChI Key AYXYPKUFHZROOJ-ZETCQYMHSA-N
Smiles CC(C)C[C@H](CN)CC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References

References are publications that support the biological activity of the product.

Field et al (2001) Pregabalin may represent a novel class of anxiolytic agents with a broad spectrum of activity. Br.J.Pharmacol. 132 1 PMID: 11156553

Kumar et al (2010) Evidence that prega. reduces neuropathic pain by inhibiting the spinal release of glutamate. J.Neurochem. 113 552 PMID: 20132471

Arain (2009) Pregabalin in the management of partial epilepsy. Neuropsych.Dis.Treat. 5 407

Keywords: Pregabalin, Pregabalin supplier, anticonvulsants, neuropathic, pain, GABA, analgesics, anxiolytics, a2d, alpha2delta, α2δ, voltage-sensitive, calcium, channels, Ca2+, Non-selective, Cav, Channels, 3775, Tocris Bioscience

Citations for Pregabalin

Citations are publications that use Tocris products.

Currently there are no citations for Pregabalin.

Reviews for Pregabalin

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Pregabalin was observed to understand its production of dose-dependent increase in the brain expression of L-GAD.
By Anonymous on 12/26/2019
Species: Human

Pregabalin was observed to understand its production of dose-dependent increase in the brain expression of L-glutamic acid decarboxylase (GAD), the enzyme responsible for synthesizing GABA, and hence how it may have some indirect GABAergic effects by increasing GABA levels in the brain.

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