Pregabalin

Pricing Availability Delivery Time Qty
Cat.No. 3775 - Pregabalin | C8H17NO2 | CAS No. 148553-50-8
Description: Anticonvulsant; selectively binds the α2δ subunit of voltage-sensitive calcium channels
Chemical Name: (S)-3-(Aminomethyl)-5-methylhexanoic acid
Datasheet
Citations
Reviews
Literature

Biological Activity

Anticonvulsant and antiepileptic; also used to treat neuropathic pain. Binds with high affinity and selectivity to the α2δ subunit of voltage-sensitive Ca2+ channels and modulates their activity. Displays anxiolytic-like activity in ethological and conflict models of anxiety. Analog of GABA (Cat. No. 0344).

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M. Wt 159.23
Formula C8H17NO2
Storage Store at RT
CAS Number 148553-50-8
PubChem ID 5486971
InChI Key AYXYPKUFHZROOJ-ZETCQYMHSA-N
Smiles CC(C)C[C@H](CN)CC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 15.92 100

Preparing Stock Solutions

The following data is based on the product molecular weight 159.23. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 6.28 mL 31.4 mL 62.8 mL
5 mM 1.26 mL 6.28 mL 12.56 mL
10 mM 0.63 mL 3.14 mL 6.28 mL
50 mM 0.13 mL 0.63 mL 1.26 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Field et al (2001) Pregabalin may represent a novel class of anxiolytic agents with a broad spectrum of activity. Br.J.Pharmacol. 132 1 PMID: 11156553

Kumar et al (2010) Evidence that pregabalin reduces neuropathic pain by inhibiting the spinal release of glutamate. J.Neurochem. 113 552 PMID: 20132471

Arain (2009) Pregabalin in the management of partial epilepsy. Neuropsych.Dis.Treat. 5 407


If you know of a relevant reference for Pregabalin, please let us know.

Keywords: Pregabalin, Pregabalin supplier, anticonvulsants, neuropathic, pain, GABA, analgesics, anxiolytics, a2d, alpha2delta, α2δ, voltage-sensitive, calcium, channels, Ca2+, Voltage-gated, Calcium, Channels, 3775, Tocris Bioscience

Citations for Pregabalin

Citations are publications that use Tocris products.

Currently there are no citations for Pregabalin. Do you know of a great paper that uses Pregabalin from Tocris? Please let us know.

Reviews for Pregabalin

There are currently no reviews for this product. Be the first to review Pregabalin and earn rewards!

Have you used Pregabalin?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
Ion Channel

Ion Channel Product Listing

A collection of around 500 products for ion channel research, the listing includes research tools for the study of:

  • Ligand-gated ion channels
  • Voltage-gated ion channels
  • Other Ion Channels
Pain

Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
Depression

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

Epilepsy

Epilepsy Poster

Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.