Pregabalin

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Cat.No. 3775 - Pregabalin | C8H17NO2 | CAS No. 148553-50-8
Description: Anticonvulsant; selectively binds the α2δ subunit of voltage-sensitive calcium channels
Chemical Name: (S)-3-(Aminomethyl)-5-methylhexanoic acid
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Biological Activity

Anticonvulsant and antiepileptic; also used to treat neuropathic pain. Binds with high affinity and selectivity to the α2δ subunit of voltage-sensitive Ca2+ channels and modulates their activity. Displays anxiolytic-like activity in ethological and conflict models of anxiety. Analog of GABA (Cat. No. 0344).

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M. Wt 159.23
Formula C8H17NO2
Storage Store at RT
CAS Number 148553-50-8
PubChem ID 5486971
InChI Key AYXYPKUFHZROOJ-ZETCQYMHSA-N
Smiles CC(C)C[C@H](CN)CC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 15.92 100

Preparing Stock Solutions

The following data is based on the product molecular weight 159.23. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 6.28 mL 31.4 mL 62.8 mL
5 mM 1.26 mL 6.28 mL 12.56 mL
10 mM 0.63 mL 3.14 mL 6.28 mL
50 mM 0.13 mL 0.63 mL 1.26 mL

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References

References are publications that support the products' biological activity.

Field et al (2001) Pregabalin may represent a novel class of anxiolytic agents with a broad spectrum of activity. Br.J.Pharmacol. 132 1 PMID: 11156553

Kumar et al (2010) Evidence that pregabalin reduces neuropathic pain by inhibiting the spinal release of glutamate. J.Neurochem. 113 552 PMID: 20132471

Arain (2009) Pregabalin in the management of partial epilepsy. Neuropsych.Dis.Treat. 5 407 PMID:


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Keywords: anticonvulsants neuropathic pain GABA analgesics anxiolytics a2d alpha2delta α2δ voltage-sensitive calcium channels Ca2+ Voltage-gated Calcium Channels

Citations for Pregabalin

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Literature in this Area

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Pathways for Pregabalin

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