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PR 39 (porcine)

Cat. No. 1947 1 Citation Submit a Review Datasheet / COA / SDS

Discontinued Product

PR 39 (porcine) (Cat. No. 1947) has been withdrawn from sale for commercial reasons.
Description: IκBα inhibitor
Datasheet
Citations (1)
Reviews
Literature (2)
Pathways (1)
Biological Activity Technical Data Datasheets References

Biological Activity for PR 39 (porcine)

PR 39 (porcine) is an antibacterial peptide. Stimulates angiogenesis and inhibits inflammatory responses by selectively blocking proteasome degradation of IκBα.

Technical Data for PR 39 (porcine)

M. Wt 4719.7
Formula C229H346N70O40
Sequence RRRPRPPYLPRPRPPPFFPPRLPPRIPPGFPPRFPPRFP

(Modifications: Pro-39 = C-terminal amide)
Storage Desiccate at -20°C
CAS Number 139637-11-9
PubChem ID 52949575
InChI Key SVJCYLXJXIRSHM-IWDHFESKSA-N
Smiles [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N1CCC[C@H]1C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for PR 39 (porcine)

Certificate of Analysis / Product Datasheet
Safety Datasheet

References for PR 39 (porcine)

References are publications that support the biological activity of the product.

Gaczynska et al (2003) Proline and arginine-rich peptides constitute a novel class of allosteric inhibitors of proteasome activity. Biochemistry 42 8663 PMID: 12873125

Gao et al (2000) Inhibition of ubiquitin-proteasome pathway-mediated IκBα degradation by a naturally occuring antibacterial peptide. J.Clin.Invest. 106 439 PMID: 10930447

Li et al (2000) PR39, a peptide regulator of angiogenesis. Nat.Med. 6 356 PMID: 10613823

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Keywords: PR 39, PR 39 supplier, IκB, IκBα, IkappaBalpha, blocks, degradation, inhibitors, inhibits, NF-κB, NF-kappaB, Nf-kB, Transcription, Factors, Nuclear, Factor, Kappa, B, PR39, NF-kB/IkB, 1947, Tocris Bioscience

1 Citation for PR 39 (porcine)

Citations are publications that use Tocris products. Selected citations for PR 39 (porcine) include:

Yan et al (2015) Stimulation of hepatocarcinogenesis by neutrophils upon induction of oncogenic kras expression in transgenic zebrafish. J Hepatol 63 420 PMID: 25828472

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Literature in this Area

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Pathways for PR 39 (porcine)

NF-κB Signaling Pathway

NF-κB Signaling Pathway

NF-κB signaling plays an important role in inflammation, the innate and adaptive immune response and stress. Dysregulated signaling can occur in inflammatory and autoimmune diseases.