PP 121

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Cat.No. 3894 - PP 121 | C17H17N7 | CAS No. 1092788-83-4
Description: Dual kinase inhibitor; inhibits PI 3-K family kinases
Chemical Name: 1-Cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Dual inhibitor of receptor tyrosine kinases (RTKs) (IC50 < 0.02 μM for Abl, Src, VEGFR-2 and PDGFR) and PI 3-K family kinases (IC50 < 0.06 μM for p110α, DNA-PK and mTOR). Exhibits no significant effect on receptor serine/threonine kinases (RSTKs). Blocks the proliferation of tumor cells by direct inhibition of PI 3-K, mTOR, Src and the VEGF receptor.

Compound Libraries

PP 121 is also offered as part of the Tocriscreen Plus and Tocriscreen Kinase Inhibitor Toolbox I. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 319.36
Formula C17H17N7
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1092788-83-4
PubChem ID 24905142
InChI Key NVRXTLZYXZNATH-UHFFFAOYSA-N
Smiles NC1=C2C(N(C5CCCC5)N=C2C3=CN=C(NC=C4)C4=C3)=NC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 31.94 100
ethanol 15.97 50

Preparing Stock Solutions

The following data is based on the product molecular weight 319.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.13 mL 15.66 mL 31.31 mL
5 mM 0.63 mL 3.13 mL 6.26 mL
10 mM 0.31 mL 1.57 mL 3.13 mL
50 mM 0.06 mL 0.31 mL 0.63 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Apsel et al (2008) Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. Nat.Chem.Biol. 4 691 PMID: 18849971


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Keywords: PP 121, PP 121 supplier, PP121, PI, 3-K, 3-kinase, PI3K, dual, inhibitors, inhibits, receptor, tyrosine, kinases, RTKs, 3-Kinase, mTOR, Other, 3894, Tocris Bioscience

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Literature in this Area

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