Pricing Availability   Qty
Description: TRPA1 channel activator; analgesic and antifungal
Chemical Name: (1R,4aS,8aS)-1,4,4a,5,6,7,8,8a-Octahydro-5,5,8a-trimethyl-1,2-naphthalenedicarboxaldehyde
Purity: ≥97% (HPLC)
Citations (2)

Biological Activity for Polygodial

Polygodial is a TRPA1 channel activator (EC50 = 400 nM) that is selective against TRPV1, TRPV2, TRPV3, TRPV4 and TRPM8 channels. Acts as an analgesic via desensitization of sensory neurons. Also exhibits antifungal activity via inhibition of mitochondrial ATPase.

Compound Libraries for Polygodial

Polygodial is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Polygodial

M. Wt 234.33
Formula C15H22O2
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 6754-20-7
PubChem ID 72503
Smiles [H][C@]12C(C)(C)CCC[C@@](C)1[C@@H](C=O)C(C=O)=CC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Polygodial

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 23.43 100
ethanol 23.43 100

Preparing Stock Solutions for Polygodial

The following data is based on the product molecular weight 234.33. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.27 mL 21.34 mL 42.67 mL
5 mM 0.85 mL 4.27 mL 8.53 mL
10 mM 0.43 mL 2.13 mL 4.27 mL
50 mM 0.09 mL 0.43 mL 0.85 mL

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Product Datasheets for Polygodial

Certificate of Analysis / Product Datasheet
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References for Polygodial

References are publications that support the biological activity of the product.

Lunde and Kubo (2000) Effect of polygodial on the mitochondrial ATPase of Saccharomyces cerevisiae. Antimicrob.Agents Chemother. 44 1943 PMID: 10858359

Escalera et al (2008) TRPA1 mediates the noxious effects of natural sesquiterpene deterrents. J.Biol.Chem. 283 24136 PMID: 18550530

Matsuda et al (2002) Protective effect of polygodial and related compounds on ethanol-induced gastric mucosal lesions in rats: structural requirements and mode of action. Bioorg.Med.Chem.Letts. 12 477 PMID: 11814823

If you know of a relevant reference for Polygodial, please let us know.

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Keywords: Polygodial, Polygodial supplier, TRPA1, channel, activator, mitochondrial, ATPase, antifungal, inhibits, Other, ATPases, Antifungals, 3197, Tocris Bioscience

2 Citations for Polygodial

Citations are publications that use Tocris products. Selected citations for Polygodial include:

Silverman et al (2023) Transient Receptor Potential Ankyrin-1-expressing vagus nerve fibers mediate IL-1 beta induced hypothermia and reflex anti-inflammatory responses. Mol Med 29 4 PMID: 36650454

Shi et al (2015) Alterations in serotonin, transient receptor potential channels and protease-activated receptors in rats with irritable bowel syndrome attenuated by Shugan decoction. Mol Cancer 21 4852 PMID: 25944998

Do you know of a great paper that uses Polygodial from Tocris? Please let us know.

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