Polygodial

Pricing Availability Delivery Time Qty
Cat.No. 3197 - Polygodial | C15H22O2 | CAS No. 6754-20-7
Description: TRPA1 channel activator; analgesic and antifungal
Chemical Name: (1R,4aS,8aS)-1,4,4a,5,6,7,8,8a-Octahydro-5,5,8a-trimethyl-1,2-naphthalenedicarboxaldehyde
Purity: ≥97% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

TRPA1 channel activator (EC50 = 400 nM) that is selective against TRPV1, TRPV2, TRPV3, TRPV4 and TRPM8 channels. Acts as an analgesic via desensitization of sensory neurons. Also exhibits antifungal activity via inhibition of mitochondrial ATPase.

Technical Data

M. Wt 234.33
Formula C15H22O2
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 6754-20-7
PubChem ID 72503
InChI Key AZJUJOFIHHNCSV-KCQAQPDRSA-N
Smiles [H][C@]12C(C)(C)CCC[C@@](C)1[C@@H](C=O)C(C=O)=CC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 23.43 100
ethanol 23.43 100

Preparing Stock Solutions

The following data is based on the product molecular weight 234.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.27 mL 21.34 mL 42.67 mL
5 mM 0.85 mL 4.27 mL 8.53 mL
10 mM 0.43 mL 2.13 mL 4.27 mL
50 mM 0.09 mL 0.43 mL 0.85 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Lunde and Kubo (2000) Effect of polygodial on the mitochondrial ATPase of Saccharomyces cerevisiae. Antimicrob.Agents Chemother. 44 1943 PMID: 10858359

Escalera et al (2008) TRPA1 mediates the noxious effects of natural sesquiterpene deterrents. J.Biol.Chem. 283 24136 PMID: 18550530

Matsuda et al (2002) Protective effect of polygodial and related compounds on ethanol-induced gastric mucosal lesions in rats: structural requirements and mode of action. Bioorg.Med.Chem.Letts. 12 477 PMID:


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Keywords: Polygodial, supplier, TRPA1, channel, activator, mitochondrial, ATPase, antifungal, inhibits, mitochondrial, ATPase, TRPA1, Other, ATPases, TRPA1, Tocris Bioscience

1 Citation for Polygodial

Citations are publications that use Tocris products. Selected citations for Polygodial include:

Shi et al (2015) Alterations in serotonin, transient receptor potential channels and protease-activated receptors in rats with irritable bowel syndrome attenuated by Shugan decoction. Mol Cancer 21 4852 PMID: 25944998


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