PNU 96415E

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Cat.No. 2735 - PNU 96415E | C21H25FN2O.2HCl | CAS No. 170856-41-4
Description: D4 and 5-HT2A antagonist; antipsychotic
Chemical Name: 1-[2-(3,4-Dihydro-1H-2-benzopyran-1-yl)ethyl]-4-(4-fluorophenyl)piperazine dihydrochloride
Purity: ≥98% (HPLC)
Citations (1)
Literature (4)

Biological Activity for PNU 96415E

PNU 96415E is an antipsychotic agent. Displays high affinity for dopamine D4 and serotonergic 5-HT2A receptors and relatively weak affinity at D2 receptors (Ki values are 3.0, 5.8, 134, 181, 199, 240, 411 and > 678 nM for D4, 5-HT2A, 5-HT1A, α1, D2, D3, D1, α2 and muscarinic receptors respectively). Inhibits exploratory locomotor activity and antagonizes d-amphetamine-induced locomotor stimulation in rats.

Technical Data for PNU 96415E

M. Wt 413.36
Formula C21H25FN2O.2HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 170856-41-4
PubChem ID 9909647
Smiles FC(C=C4)=CC=C4N(CC3)CCN3CCC2C1=CC=CC=C1CCO2.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PNU 96415E

Solvent Max Conc. mg/mL Max Conc. mM
water 4.13 10

Preparing Stock Solutions for PNU 96415E

The following data is based on the product molecular weight 413.36. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.19 mL 120.96 mL 241.92 mL
0.5 mM 4.84 mL 24.19 mL 48.38 mL
1 mM 2.42 mL 12.1 mL 24.19 mL
5 mM 0.48 mL 2.42 mL 4.84 mL

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Product Datasheets for PNU 96415E

Certificate of Analysis / Product Datasheet
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References for PNU 96415E

References are publications that support the biological activity of the product.

Tang et al (1997) PNU-96415E, a potential antipsychotic agent with clozapine-like pharmacological properties. J.Pharmacol.Exp.Ther. 281 440 PMID: 9103528

Goudie et al (1998) Discriminative stimulus properties of the atypical neuroleptic cloz. in rats: tests with subtype selective receptor ligands. Behav.Pharmacol. 9 699 PMID: 9890260

If you know of a relevant reference for PNU 96415E, please let us know.

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Keywords: PNU 96415E, PNU 96415E supplier, 5-HT2A, D4, antagonists, antipsychotic, Serotonin, Receptors, Dopamine, dopaminergic, PNU96415E, 2735, Tocris Bioscience

1 Citation for PNU 96415E

Citations are publications that use Tocris products. Selected citations for PNU 96415E include:

Dolma et al (2016) Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells. Cancer Cell 29 859 PMID: 27300435

Do you know of a great paper that uses PNU 96415E from Tocris? Please let us know.

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