PNU 96415E

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Cat.No. 2735 - PNU 96415E | C21H25FN2O.2HCl | CAS No. 170856-41-4
Description: D4 and 5-HT2A antagonist; antipsychotic
Chemical Name: 1-[2-(3,4-Dihydro-1H-2-benzopyran-1-yl)ethyl]-4-(4-fluorophenyl)piperazine dihydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Antipsychotic agent. Displays high affinity for dopamine D4 and serotonergic 5-HT2A receptors and relatively weak affinity at D2 receptors (Ki values are 3.0, 5.8, 134, 181, 199, 240, 411 and > 678 nM for D4, 5-HT2A, 5-HT1A, α1, D2, D3, D1, α2 and muscarinic receptors respectively). Inhibits exploratory locomotor activity and antagonizes d-amphetamine-induced locomotor stimulation in rats.

Technical Data

M. Wt 413.36
Formula C21H25FN2O.2HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 170856-41-4
PubChem ID 9909647
InChI Key OGMGYKPECFQXJJ-UHFFFAOYSA-N
Smiles FC(C=C4)=CC=C4N(CC3)CCN3CCC2C1=CC=CC=C1CCO2.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 4.13 10

Preparing Stock Solutions

The following data is based on the product molecular weight 413.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.19 mL 120.96 mL 241.92 mL
0.5 mM 4.84 mL 24.19 mL 48.38 mL
1 mM 2.42 mL 12.1 mL 24.19 mL
5 mM 0.48 mL 2.42 mL 4.84 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Tang et al (1997) PNU-96415E, a potential antipsychotic agent with clozapine-like pharmacological properties. J.Pharmacol.Exp.Ther. 281 440 PMID: 9103528

Goudie et al (1998) Discriminative stimulus properties of the atypical neuroleptic clozapine in rats: tests with subtype selective receptor ligands. Behav.Pharmacol. 9 699 PMID: 9890260


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