PNU 37883 hydrochloride

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Cat.No. 2095 - PNU 37883 hydrochloride | C21H35N3O.HCl | CAS No. 57568-80-6
Description: Vascular Kir6 (KATP) channel blocker
Chemical Name: N-Cyclohexyl-N'-tricyclo[3.3.1.13,7]dec-1-yl-4-morpholinecarboximidamide hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Novel antagonist selective for the vascular form of Kir6 (KATP) channel; inhibits Kir6 currents in isolated mesenteric artery smooth muscle cells (Kd = 65 nM) but not in cardiac or skeletal myocytes. Inhibits blood vessel relaxation and hypotension induced by pinacidil in vivo. Displays weak diuretic effects.

Compound Libraries

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Technical Data

M. Wt 381.98
Formula C21H35N3O.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 57568-80-6
PubChem ID 64392
InChI Key FZALCKUJYZCDOX-UHFFFAOYSA-N
Smiles C1(CC3C2)CC2(/N=C(N5CCOCC5)/NC4CCCCC4)CC(C3)C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 9.55 25
ethanol 38.2 100

Preparing Stock Solutions

The following data is based on the product molecular weight 381.98. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.62 mL 13.09 mL 26.18 mL
5 mM 0.52 mL 2.62 mL 5.24 mL
10 mM 0.26 mL 1.31 mL 2.62 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Humphrey and Ludens (1998) KATP-blocking diuretic PNU-37883A reduces plasma renin activity in dogs. J.Cardiovasc.Pharmacol. 31 894 PMID: 9641474

Cui et al (2003) Different molecular sites of action for the KATP channel inhibitors, PNU-99963 and PNU-37883A. Br.J.Pharmacol. 139 122 PMID: 12746230

Kovalev et al (2004) Molecular analysis of the subtype-selective inhibition of cloned KATP channels by PNU-37883A. Br.J.Pharmacol. 141 867 PMID: 14757705


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Citations for PNU 37883 hydrochloride

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Literature in this Area

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Pathways for PNU 37883 hydrochloride

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