PNU 37883 hydrochloride

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Cat.No. 2095 - PNU 37883 hydrochloride | C21H35N3O.HCl | CAS No. 57568-80-6
Description: Vascular Kir6 (KATP) channel blocker
Chemical Name: N-Cyclohexyl-N'-tricyclo[3.3.1.13,7]dec-1-yl-4-morpholinecarboximidamide hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews (1)
Literature (3)

Biological Activity

Novel antagonist selective for the vascular form of Kir6 (KATP) channel; inhibits Kir6 currents in isolated mesenteric artery smooth muscle cells (Kd = 65 nM) but not in cardiac or skeletal myocytes. Inhibits blood vessel relaxation and hypotension induced by pinacidil in vivo. Displays weak diuretic effects.

Compound Libraries

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Technical Data

M. Wt 381.98
Formula C21H35N3O.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 57568-80-6
PubChem ID 64392
InChI Key FZALCKUJYZCDOX-UHFFFAOYSA-N
Smiles C1(CC3C2)CC2(/N=C(N5CCOCC5)/NC4CCCCC4)CC(C3)C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 9.55 25
ethanol 38.2 100

Preparing Stock Solutions

The following data is based on the product molecular weight 381.98. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.62 mL 13.09 mL 26.18 mL
5 mM 0.52 mL 2.62 mL 5.24 mL
10 mM 0.26 mL 1.31 mL 2.62 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

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References

References are publications that support the biological activity of the product.

Humphrey and Ludens (1998) KATP-blocking diuretic PNU-37883A reduces plasma renin activity in dogs. J.Cardiovasc.Pharmacol. 31 894 PMID: 9641474

Cui et al (2003) Different molecular sites of action for the KATP channel inhibitors, PNU-99963 and PNU-37883A. Br.J.Pharmacol. 139 122 PMID: 12746230

Kovalev et al (2004) Molecular analysis of the subtype-selective inhibition of cloned KATP channels by PNU-37883A. Br.J.Pharmacol. 141 867 PMID: 14757705


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View Related Products by Product Action

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Keywords: PNU 37883 hydrochloride, PNU 37883 hydrochloride supplier, Vascular, KATP, channels, blockers, Potassium, KIR, Inward, Rectifier, K+, PNU37883, hydrochloride, antagonist, Kir6, rectifier, Channels, 2095, Tocris Bioscience

Citations for PNU 37883 hydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for PNU 37883 hydrochloride. Do you know of a great paper that uses PNU 37883 hydrochloride from Tocris? Please let us know.

Reviews for PNU 37883 hydrochloride

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PNU 37883 was used to understand whether it shows BK channel blocking effect.
By Anonymous on 10/31/2018
Assay Type: In Vitro
Species: Human

PNU 37883 was used to understand whether it shows BK channel blocking effect. The product worked ideally although inhibition data obtained from the product shows variation.

I suggest using an alternate channel blocker to measure blocking action to identify the variation with PNU 37883.

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