PNU 37883 hydrochloride

Pricing Availability   Qty
Description: Vascular Kir6 (KATP) channel blocker
Chemical Name: N-Cyclohexyl-N'-tricyclo[,7]dec-1-yl-4-morpholinecarboximidamide hydrochloride
Purity: ≥99% (HPLC)
Reviews (1)

Biological Activity for PNU 37883 hydrochloride

PNU 37883 hydrochloride is a novel antagonist selective for the vascular form of Kir6 (KATP) channel; inhibits Kir6 currents in isolated mesenteric artery smooth muscle cells (Kd = 65 nM) but not in cardiac or skeletal myocytes. Inhibits blood vessel relaxation and hypotension induced by pinacidil in vivo. Displays weak diuretic effects.

Compound Libraries for PNU 37883 hydrochloride

PNU 37883 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for PNU 37883 hydrochloride

M. Wt 381.98
Formula C21H35N3O.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 57568-80-6
PubChem ID 64392
Smiles C1(CC3C2)CC2(/N=C(N5CCOCC5)/NC4CCCCC4)CC(C3)C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PNU 37883 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 9.55 25
ethanol 38.2 100

Preparing Stock Solutions for PNU 37883 hydrochloride

The following data is based on the product molecular weight 381.98. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.62 mL 13.09 mL 26.18 mL
5 mM 0.52 mL 2.62 mL 5.24 mL
10 mM 0.26 mL 1.31 mL 2.62 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for PNU 37883 hydrochloride

References for PNU 37883 hydrochloride

References are publications that support the biological activity of the product.

Humphrey and Ludens (1998) KATP-blocking diuretic PNU-37883A reduces plasma renin activity in dogs. J.Cardiovasc.Pharmacol. 31 894 PMID: 9641474

Cui et al (2003) Different molecular sites of action for the KATP channel inhibitors, PNU-99963 and PNU-37883A. Br.J.Pharmacol. 139 122 PMID: 12746230

Kovalev et al (2004) Molecular analysis of the subtype-selective inhibition of cloned KATP channels by PNU-37883A. Br.J.Pharmacol. 141 867 PMID: 14757705

If you know of a relevant reference for PNU 37883 hydrochloride, please let us know.

View Related Products by Product Action

View all Inward Rectifier Potassium (Kir) Channel Blockers

Keywords: PNU 37883 hydrochloride, PNU 37883 hydrochloride supplier, Vascular, KATP, channels, blockers, Potassium, KIR, Inward, Rectifier, K+, PNU37883, hydrochloride, antagonist, Kir6, rectifier, Channels, 2095, Tocris Bioscience

Citations for PNU 37883 hydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for PNU 37883 hydrochloride. Do you know of a great paper that uses PNU 37883 hydrochloride from Tocris? Please let us know.

Reviews for PNU 37883 hydrochloride

Average Rating: 4 (Based on 1 Review.)

5 Star
4 Star
3 Star
2 Star
1 Star

Have you used PNU 37883 hydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:

PNU 37883 was used to understand whether it shows BK channel blocking effect.
By Anonymous on 10/31/2018
Assay Type: In Vitro
Species: Human

PNU 37883 was used to understand whether it shows BK channel blocking effect. The product worked ideally although inhibition data obtained from the product shows variation.

I suggest using an alternate channel blocker to measure blocking action to identify the variation with PNU 37883.

review image