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Cat.No. 0788 - 3-Aminobenzamide | C7H8N2O | CAS No. 3544-24-9
Description: PARP inhibitor
Alternative Names: 3-ABA
Citations (1)

Biological Activity

An inhibitor of poly(ADP-ribose) polymerase, which protects cells from UV-B-induced apoptosis via influence on the cytoskeleton.

Compound Libraries

3-Aminobenzamide is also offered as part of the Tocriscreen Epigenetics Toolbox. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 136.15
Formula C7H8N2O
Storage Store at RT
CAS Number 3544-24-9
PubChem ID 1645
Smiles NC(=O)C1=CC=CC(N)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 100 mM in water


References are publications that support the biological activity of the product.

Cuzzocrea et al (1997) Beneficial effects of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthetase in a rat model of splanchnic artery occlusion and reperfusion. Br.J.Pharmacol. 121 1065 PMID: 9249240

Malorni et al (1995) 3-Aminobenzamide protects cells from UV-B-induced apoptosis by acting on cytoskeleton and substrate adhesion. Biochem.Biophys.Res.Commun. 207 715 PMID: 7864864

If you know of a relevant reference for 3-Aminobenzamide, please let us know.

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View all Poly(ADP-Ribose) Polymerase Inhibitors

Keywords: 3-Aminobenzamide, 3-Aminobenzamide supplier, PARP, inhibitors, inhibits, PolyADP-ribose, Polymerases, 3-ABA, Poly(ADP-ribose), Polymerase, 0788, Tocris Bioscience

1 Citation for 3-Aminobenzamide

Citations are publications that use Tocris products. Selected citations for 3-Aminobenzamide include:

Pakula et al (2019) The Epithelial-Mesenchymal Transition Initiated by Malignant Ascites Underlies the Transmesothelial Invasion of Ovarian Cancer Cells. Int J Mol Sci 20 PMID: 30609691

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Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.