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Biological Activity for 3-Aminobenzamide
3-Aminobenzamide is an inhibitor of poly(ADP-ribose) polymerase, which protects cells from UV-B-induced apoptosis via influence on the cytoskeleton.
Technical Data for 3-Aminobenzamide
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for 3-Aminobenzamide
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for 3-Aminobenzamide
The following data is based on the product molecular weight 136.15. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||7.34 mL||36.72 mL||73.45 mL|
|5 mM||1.47 mL||7.34 mL||14.69 mL|
|10 mM||0.73 mL||3.67 mL||7.34 mL|
|50 mM||0.15 mL||0.73 mL||1.47 mL|
Product Datasheets for 3-Aminobenzamide
References for 3-Aminobenzamide
References are publications that support the biological activity of the product.
Cuzzocrea et al (1997) Beneficial effects of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthetase in a rat model of splanchnic artery occlusion and reperfusion. Br.J.Pharmacol. 121 1065 PMID: 9249240
Malorni et al (1995) 3-Aminobenzamide protects cells from UV-B-induced apoptosis by acting on cytoskeleton and substrate adhesion. Biochem.Biophys.Res.Commun. 207 715 PMID: 7864864
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Keywords: 3-Aminobenzamide, 3-Aminobenzamide supplier, PARP, inhibitors, inhibits, PolyADP-ribose, Polymerases, 3-ABA, Poly(ADP-ribose), Polymerase, 0788, Tocris Bioscience
1 Citation for 3-Aminobenzamide
Citations are publications that use Tocris products. Selected citations for 3-Aminobenzamide include:
Pakula et al (2019) The Epithelial-Mesenchymal Transition Initiated by Malignant Ascites Underlies the Transmesothelial Invasion of Ovarian Cancer Cells. Int J Mol Sci 20 PMID: 30609691
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Literature in this Area
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Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.