3-Aminobenzamide

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Cat.No. 0788 - 3-Aminobenzamide | C7H8N2O | CAS No. 3544-24-9
Description: PARP inhibitor
Alternative Names: 3-ABA
Datasheet
Citations
Literature

Biological Activity

An inhibitor of poly(ADP-ribose) polymerase, which protects cells from UV-B-induced apoptosis via influence on the cytoskeleton.

Compound Libraries

3-Aminobenzamide is also offered as part of the Tocriscreen Epigenetics Toolbox. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 136.15
Formula C7H8N2O
Storage Store at RT
CAS Number 3544-24-9
PubChem ID 1645
InChI Key GSCPDZHWVNUUFI-UHFFFAOYSA-N
Smiles NC(=O)C1=CC=CC(N)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in water

Preparing Stock Solutions

The following data is based on the product molecular weight 136.15. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 7.34 mL 36.72 mL 73.45 mL
5 mM 1.47 mL 7.34 mL 14.69 mL
10 mM 0.73 mL 3.67 mL 7.34 mL
50 mM 0.15 mL 0.73 mL 1.47 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Cuzzocrea et al (1997) Beneficial effects of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthetase in a rat model of splanchnic artery occlusion and reperfusion. Br.J.Pharmacol. 121 1065 PMID: 9249240

Malorni et al (1995) 3-Aminobenzamide protects cells from UV-B-induced apoptosis by acting on cytoskeleton and substrate adhesion. Biochem.Biophys.Res.Commun. 207 715 PMID: 7864864


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View Related Products by Product Action

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Citations for 3-Aminobenzamide

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Literature in this Area

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Cell Cycle & DNA Damage Repair

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.

Pathways for 3-Aminobenzamide

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