PI 828

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Cat.No. 2814 - PI 828 | C19H18N2O3 | CAS No. 942289-87-4
Description: PI 3-kinase inhibitor, more potent than LY 294002 (Cat. No. 1130)
Chemical Name: 2-(4-Morpholinyl)-8-(4-aminopheny)l-4H-1-benzopyran-4-one
Purity: ≥99% (HPLC)
Datasheet
Citations (4)
Reviews
Literature

Biological Activity

PI 3-Kinase inhibitor (IC50 values are 0.098, 0.183, 0.227 and 1.967 μM for p110β, p110α, p110δ and p110γ respectively) that displays higher potency than LY 294002 (Cat No. 1130). Can be immobilized onto a solid phase.

Compound Libraries

PI 828 is also offered as part of the Tocriscreen Plus and Tocriscreen Kinase Inhibitor Toolbox I. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 322.36
Formula C19H18N2O3
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 942289-87-4
PubChem ID 25181195
InChI Key WUKMIBOGGXMBAC-UHFFFAOYSA-N
Smiles O=C2C=C(N3CCOCC3)OC1=C(C4=CC=C(N)C=C4)C=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 32.24 100

Preparing Stock Solutions

The following data is based on the product molecular weight 322.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.1 mL 15.51 mL 31.02 mL
5 mM 0.62 mL 3.1 mL 6.2 mL
10 mM 0.31 mL 1.55 mL 3.1 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Gharbi et al (2007) Exploring the specificity of the PI3K family inhibitor LY294002. Biochem.J. 404 15 PMID: 17302559


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View Related Products by Product Action

View all PI 3-kinase Inhibitors

Keywords: PI 828, PI 828 supplier, PI, 3-kinase, inhibitors, inhibits, potent, LY, 294002, PI3K, Phosphoinositide, 3-Kinases, PI828, 3-Kinase, Inositol, Lipids, 2814, Tocris Bioscience

4 Citations for PI 828

Citations are publications that use Tocris products. Selected citations for PI 828 include:

Grassin-Delyle et al (2013) The expression and relaxant effect of bitter taste receptors in human bronchi. Respir Res 14 134 PMID: 24266887

Rogers and Gahring (2015) Upregulation of Nicotinic Acetylcholine Receptor α4+β2 through a Ligand-Independent PI3Kβ Mechanism That Is Enhanced by TNFα and the Jak2/p38Mapk Pathways. J Neurosci 10 e0143319 PMID: 26619345

Li et al (2011) TRPV4-mediated calcium influx into human bronchial epithelia upon exposure to diesel exhaust particles. Environ Health Perspect 119 784 PMID: 21245013

Moser et al (2014) Functional kinomics identifies candidate therapeutic targets in head and neck cancer. Clin Cancer Res 20 4274 PMID: 25125259


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Reviews for PI 828

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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