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PI 828

Cat. No. 2814 4 Citations Submit a Review Datasheet / COA / SDS
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Cat.No. 2814 - PI 828 | C19H18N2O3 | CAS No. 942289-87-4
Description: PI 3-kinase inhibitor, more potent than LY 294002 (Cat. No. 1130)
Chemical Name: 2-(4-Morpholinyl)-8-(4-aminopheny)l-4H-1-benzopyran-4-one
Purity: ≥99% (HPLC)
Datasheet
Citations (4)
Reviews
Literature
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

PI 3-Kinase inhibitor (IC50 values are 0.098, 0.183, 0.227 and 1.967 μM for p110β, p110α, p110δ and p110γ respectively) that displays higher potency than LY 294002 (Cat No. 1130). Can be immobilized onto a solid phase.

Compound Libraries

PI 828 is also offered as part of the Tocriscreen Plus and Tocriscreen Kinase Inhibitor Toolbox I. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 322.36
Formula C19H18N2O3
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 942289-87-4
PubChem ID 25181195
InChI Key WUKMIBOGGXMBAC-UHFFFAOYSA-N
Smiles O=C2C=C(N3CCOCC3)OC1=C(C4=CC=C(N)C=C4)C=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 32.24 100

Preparing Stock Solutions

The following data is based on the product molecular weight 322.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.1 mL 15.51 mL 31.02 mL
5 mM 0.62 mL 3.1 mL 6.2 mL
10 mM 0.31 mL 1.55 mL 3.1 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the biological activity of the product.

Gharbi et al (2007) Exploring the specificity of the PI3K family inhibitor LY294002. Biochem.J. 404 15 PMID: 17302559

If you know of a relevant reference for PI 828, please let us know.

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Keywords: PI 828, PI 828 supplier, PI, 3-kinase, inhibitors, inhibits, potent, LY, 294002, PI3K, Phosphoinositide, 3-Kinases, PI828, 3-Kinase, Inositol, Lipids, 2814, Tocris Bioscience

4 Citations for PI 828

Citations are publications that use Tocris products. Selected citations for PI 828 include:

Grassin-Delyle et al (2013) The expression and relaxant effect of bitter taste receptors in human bronchi. Respir Res 14 134 PMID: 24266887

Rogers and Gahring (2015) Upregulation of Nicotinic Acetylcholine Receptor α4+β2 through a Ligand-Independent PI3Kβ Mechanism That Is Enhanced by TNFα and the Jak2/p38Mapk Pathways. J Neurosci 10 e0143319 PMID: 26619345

Li et al (2011) TRPV4-mediated calcium influx into human bronchial epithelia upon exposure to diesel exhaust particles. Environ Health Perspect 119 784 PMID: 21245013

Moser et al (2014) Functional kinomics identifies candidate therapeutic targets in head and neck cancer. Clin Cancer Res 20 4274 PMID: 25125259

Do you know of a great paper that uses PI 828 from Tocris? Please let us know.

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Literature in this Area

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